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Anatomie comparée de l’arc aortique de l’homme, des animaux domestiques et des animaux de laboratoire: à la recherche d’un modèle pour faciliter l’étude des maladies vasculaires humaines

Christophe Casteleyn (UGent) , Pieter Cornillie (UGent) and Paul Simoens (UGent)
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Abstract
The human aortic arch and its main branches are frequently affected by pathologies, of which the development is directly related to the arterial geometry. Since interest in animal models to facilitate the study of such diseases is currently increasing, we aimed to determine to what extent the geometry and the branching pattern of the aortic arches of the mouse, rat, rabbit, rhesus monkey, cat, dog, pig and horse resemble that of man. The aortic arches of these animal species were visualized by injecting a polymerizing solution into the arterial system followed by maceration of the soft tissues. The three-dimensional organization of the aortic arches and their branches were compared between these animal species and humans. In the mouse and the rat, the brachiocephalic trunk, the left common carotid artery and the left subclavian artery branch subsequently from the aortic arch like in humans. Additionally, the aortic arches of these rodent animal species do not lie in a single sagittal plane (non-planer aortic pattern) which is also the case in humans. Therefore, the mouse and the rat model appear to be most suitable to study human vascular diseases, since both the geometry and the vascular branching pattern of the murine type of aortic arch are very similar to that of man.
Keywords
vascular pathology, geometry, animal model, Aortic arch, arteries

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Citation

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Chicago
Casteleyn, Christophe, Pieter Cornillie, and Paul Simoens. 2010. “Anatomie Comparée De L’arc Aortique De L'homme, Des Animaux Domestiques Et Des Animaux De Laboratoire: à La Recherche D'un Modèle Pour Faciliter L'étude Des Maladies Vasculaires Humaines.” SCIENCES ET TECHNIQUES DE L’ANIMAL DE LABOTOIRE 36: 41–45.
APA
Casteleyn, C., Cornillie, P., & Simoens, P. (2010). Anatomie comparée de l’arc aortique de l'homme, des animaux domestiques et des animaux de laboratoire: à la recherche d'un modèle pour faciliter l'étude des maladies vasculaires humaines. SCIENCES ET TECHNIQUES DE L’ANIMAL DE LABOTOIRE, 36, 41–45.
Vancouver
1.
Casteleyn C, Cornillie P, Simoens P. Anatomie comparée de l’arc aortique de l'homme, des animaux domestiques et des animaux de laboratoire: à la recherche d'un modèle pour faciliter l'étude des maladies vasculaires humaines. SCIENCES ET TECHNIQUES DE L’ANIMAL DE LABOTOIRE. 2010;36:41–5.
MLA
Casteleyn, Christophe, Pieter Cornillie, and Paul Simoens. “Anatomie Comparée De L’arc Aortique De L'homme, Des Animaux Domestiques Et Des Animaux De Laboratoire: à La Recherche D'un Modèle Pour Faciliter L'étude Des Maladies Vasculaires Humaines.” SCIENCES ET TECHNIQUES DE L’ANIMAL DE LABOTOIRE 36 (2010): 41–45. Print.
@article{1141078,
  abstract     = {The human aortic arch and its main branches are frequently affected by pathologies, of which the development is directly related to the arterial geometry. Since interest in animal models to facilitate the study of such diseases is currently increasing, we aimed to determine to what extent the
geometry and the branching pattern of the aortic arches of the mouse, rat, rabbit, rhesus monkey, cat, dog, pig and horse resemble that of man. The aortic arches of these animal species were visualized by injecting a polymerizing
solution into the arterial system followed by maceration of the
soft tissues. The three-dimensional organization of the aortic arches and their branches were compared between these animal species and humans. In the mouse and the rat, the brachiocephalic trunk, the left common carotid artery and the left subclavian artery branch subsequently from the aortic arch like in humans. Additionally, the aortic arches of these rodent animal species do not lie in a single sagittal plane (non-planer aortic pattern) which is also the case in humans. Therefore, the mouse and the rat model appear to be most suitable to study human vascular diseases, since both the geometry and the vascular branching pattern of the murine type of aortic arch are very similar to that of man.},
  author       = {Casteleyn, Christophe and Cornillie, Pieter and Simoens, Paul},
  issn         = {0339-722X},
  journal      = {SCIENCES ET TECHNIQUES DE L'ANIMAL DE LABOTOIRE},
  keyword      = {vascular pathology,geometry,animal model,Aortic arch,arteries},
  language     = {fre},
  pages        = {41--45},
  title        = {Anatomie compar{\'e}e de l{\textquoteright}arc aortique de l{\textquoteright}homme, des animaux domestiques et des animaux de laboratoire: {\`a} la recherche d{\textquoteright}un mod{\`e}le pour faciliter l{\textquoteright}{\'e}tude des maladies vasculaires humaines},
  volume       = {36},
  year         = {2010},
}