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74As-arsenate metabolism in Flemish Giant rabbits with renal insufficiency

Jurgen De Kimpe, Rita Cornelis, Louis Mees, Raymond Vanholder UGent and Geert Verhoeven UGent (1999) JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. 13(1-2). p.7-14
abstract
The metabolic management of carrier-free As-74-arsenate (As(V)) by uremic rabbits of the strain Flemish Giant was studied. Renal insufficiency was induced by nephrectomy of respectively 1 kidney (3/6 nephrectomy) and 1 kidney + 2/3 remaining kidney (5/6 nephrectomy). Marginal renal insufficiency developed in the 3/6 nephrectomized group, while animals of the 5/6 group became severely uremic. Renal excretion of As-74 was reduced by 90% in 5/6 nephrectomized animals 4 h after intraperitoneal injection (i.p) of the animals. The associated uremic syndrome caused a strong decrease in methylation capacity of inorganic arsenic (As-i). The second methylation step from monomethylarsonic acid (MMA) to dimethylarsinic acid (DMA) was more strongly affected than the first one, from arsenite (As(III)) to MMA. The increased availability of As-i led to more extensive binding to insoluble tissue constituents after 5/6 nephrectomy. The decreased renal reduction of As(V) led to a decrease in As(III) and an increase of As(V) and the associated As(V)-transferrin binding in plasma. Uptake of As-74-transferrin by the bone marrow might contribute to uremic anemia.
Please use this url to cite or link to this publication:
author
organization
alternative title
As-74-arsenate metabolism in Flemish Giant rabbits with renal insufficiency
year
type
journalArticle (original)
publication status
published
subject
keyword
MECHANISM, CREATININE, ARSENATE, arsenate, ACCUMULATION, HYPOTHESIS, detoxification, uremic syndrome, METHYLATION, anemia, SERUM, HEMODIALYSIS, FAILURE, TOXICITY
journal title
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
J. Trace Elem. Med. Biol.
volume
13
issue
1-2
pages
7 - 14
Web of Science type
Article
Web of Science id
000081719600002
ISSN
0946-672X
DOI
10.1016/S0946-672X(99)80017-0
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
112255
handle
http://hdl.handle.net/1854/LU-112255
date created
2004-01-14 13:34:00
date last changed
2018-01-29 12:18:47
@article{112255,
  abstract     = {The metabolic management of carrier-free As-74-arsenate (As(V)) by uremic rabbits of the strain Flemish Giant was studied. Renal insufficiency was induced by nephrectomy of respectively 1 kidney (3/6 nephrectomy) and 1 kidney + 2/3 remaining kidney (5/6 nephrectomy). Marginal renal insufficiency developed in the 3/6 nephrectomized group, while animals of the 5/6 group became severely uremic. Renal excretion of As-74 was reduced by 90\% in 5/6 nephrectomized animals 4 h after intraperitoneal injection (i.p) of the animals. The associated uremic syndrome caused a strong decrease in methylation capacity of inorganic arsenic (As-i). The second methylation step from monomethylarsonic acid (MMA) to dimethylarsinic acid (DMA) was more strongly affected than the first one, from arsenite (As(III)) to MMA. The increased availability of As-i led to more extensive binding to insoluble tissue constituents after 5/6 nephrectomy. The decreased renal reduction of As(V) led to a decrease in As(III) and an increase of As(V) and the associated As(V)-transferrin binding in plasma. Uptake of As-74-transferrin by the bone marrow might contribute to uremic anemia.},
  author       = {De Kimpe, Jurgen and Cornelis, Rita and Mees, Louis and Vanholder, Raymond and Verhoeven, Geert},
  issn         = {0946-672X},
  journal      = {JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY},
  keyword      = {MECHANISM,CREATININE,ARSENATE,arsenate,ACCUMULATION,HYPOTHESIS,detoxification,uremic syndrome,METHYLATION,anemia,SERUM,HEMODIALYSIS,FAILURE,TOXICITY},
  language     = {eng},
  number       = {1-2},
  pages        = {7--14},
  title        = {74As-arsenate metabolism in Flemish Giant rabbits with renal insufficiency},
  url          = {http://dx.doi.org/10.1016/S0946-672X(99)80017-0},
  volume       = {13},
  year         = {1999},
}

Chicago
De Kimpe, Jurgen, Rita Cornelis, Louis Mees, Raymond Vanholder, and Geert Verhoeven. 1999. “74As-arsenate Metabolism in Flemish Giant Rabbits with Renal Insufficiency.” Journal of Trace Elements in Medicine and Biology 13 (1-2): 7–14.
APA
De Kimpe, Jurgen, Cornelis, R., Mees, L., Vanholder, R., & Verhoeven, G. (1999). 74As-arsenate metabolism in Flemish Giant rabbits with renal insufficiency. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 13(1-2), 7–14.
Vancouver
1.
De Kimpe J, Cornelis R, Mees L, Vanholder R, Verhoeven G. 74As-arsenate metabolism in Flemish Giant rabbits with renal insufficiency. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. 1999;13(1-2):7–14.
MLA
De Kimpe, Jurgen, Rita Cornelis, Louis Mees, et al. “74As-arsenate Metabolism in Flemish Giant Rabbits with Renal Insufficiency.” JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 13.1-2 (1999): 7–14. Print.