Enantiomeric separation of some amino acids and derivatives by capillary electrophoresis with 18-crown-6-tetracarboxylic acid as chiral selector
- Author
- Katleen Verleysen and Patrick Sandra (UGent)
- Organization
- Abstract
- A number of amino acids and derivatives, bought or synthesized, were analyzed by capillary electrophoresis (CE:) with optical active 18-crown-6-tetracarboxylic acid (18C6H(4)) as chiral selector. Besides the primary interaction: i.e., inclusion of the protonated primary amino function in the crown ether cavity, a second interaction mechanism between the substituents on the racemates and the carboxylic acid functions on the crown ether to enhance or suppress enantioselectivity. In certain cases, very high resolutions (R-s > 5) were noted, e.g., R-s 30 for serine benzyl ester. (C) 1999 John Wiley & Sons, Inc.
- Keywords
- capillary electrophoresis, enantioselective separations, 18-crown-6-tetracarboxylic acid (18C6H(4)), amino acids and derivatives, ZONE ELECTROPHORESIS, CYCLODEXTRINS, VANCOMYCIN
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-112195
- MLA
- Verleysen, Katleen, and Patrick Sandra. “Enantiomeric Separation of Some Amino Acids and Derivatives by Capillary Electrophoresis with 18-Crown-6-Tetracarboxylic Acid as Chiral Selector.” JOURNAL OF MICROCOLUMN SEPARATIONS, vol. 11, no. 1, 1999, pp. 37–43, doi:10.1002/(SICI)1520-667X(1999)11:1<37::AID-MCS5>3.0.CO;2-X.
- APA
- Verleysen, K., & Sandra, P. (1999). Enantiomeric separation of some amino acids and derivatives by capillary electrophoresis with 18-crown-6-tetracarboxylic acid as chiral selector. JOURNAL OF MICROCOLUMN SEPARATIONS, 11(1), 37–43. https://doi.org/10.1002/(SICI)1520-667X(1999)11:1<37::AID-MCS5>3.0.CO;2-X
- Chicago author-date
- Verleysen, Katleen, and Patrick Sandra. 1999. “Enantiomeric Separation of Some Amino Acids and Derivatives by Capillary Electrophoresis with 18-Crown-6-Tetracarboxylic Acid as Chiral Selector.” JOURNAL OF MICROCOLUMN SEPARATIONS 11 (1): 37–43. https://doi.org/10.1002/(SICI)1520-667X(1999)11:1<37::AID-MCS5>3.0.CO;2-X.
- Chicago author-date (all authors)
- Verleysen, Katleen, and Patrick Sandra. 1999. “Enantiomeric Separation of Some Amino Acids and Derivatives by Capillary Electrophoresis with 18-Crown-6-Tetracarboxylic Acid as Chiral Selector.” JOURNAL OF MICROCOLUMN SEPARATIONS 11 (1): 37–43. doi:10.1002/(SICI)1520-667X(1999)11:1<37::AID-MCS5>3.0.CO;2-X.
- Vancouver
- 1.Verleysen K, Sandra P. Enantiomeric separation of some amino acids and derivatives by capillary electrophoresis with 18-crown-6-tetracarboxylic acid as chiral selector. JOURNAL OF MICROCOLUMN SEPARATIONS. 1999;11(1):37–43.
- IEEE
- [1]K. Verleysen and P. Sandra, “Enantiomeric separation of some amino acids and derivatives by capillary electrophoresis with 18-crown-6-tetracarboxylic acid as chiral selector,” JOURNAL OF MICROCOLUMN SEPARATIONS, vol. 11, no. 1, pp. 37–43, 1999.
@article{112195, abstract = {{A number of amino acids and derivatives, bought or synthesized, were analyzed by capillary electrophoresis (CE:) with optical active 18-crown-6-tetracarboxylic acid (18C6H(4)) as chiral selector. Besides the primary interaction: i.e., inclusion of the protonated primary amino function in the crown ether cavity, a second interaction mechanism between the substituents on the racemates and the carboxylic acid functions on the crown ether to enhance or suppress enantioselectivity. In certain cases, very high resolutions (R-s > 5) were noted, e.g., R-s 30 for serine benzyl ester. (C) 1999 John Wiley & Sons, Inc.}}, author = {{Verleysen, Katleen and Sandra, Patrick}}, issn = {{1040-7685}}, journal = {{JOURNAL OF MICROCOLUMN SEPARATIONS}}, keywords = {{capillary electrophoresis,enantioselective separations,18-crown-6-tetracarboxylic acid (18C6H(4)),amino acids and derivatives,ZONE ELECTROPHORESIS,CYCLODEXTRINS,VANCOMYCIN}}, language = {{eng}}, number = {{1}}, pages = {{37--43}}, title = {{Enantiomeric separation of some amino acids and derivatives by capillary electrophoresis with 18-crown-6-tetracarboxylic acid as chiral selector}}, url = {{http://doi.org/10.1002/(SICI)1520-667X(1999)11:1<37::AID-MCS5>3.0.CO;2-X}}, volume = {{11}}, year = {{1999}}, }
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