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Novel sensitive colorimetric assay for visual detection of solid-phase bound amines

Annemieke Madder UGent, Nadia Farcy, NGC Hosten, Hilde De Muynck, Pierre De Clercq UGent, J Barry and APA Davis (1999) EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 11. p.2787-2791
abstract
A new simple and efficient method for the detection of incomplete coupling reactions during solid-phase peptide synthesis is decribed. Using p-nitrophenyl ester 1 (NF31), free amino groups can be visually detected on the resin by direct coloring of the beads. A specific feature of the assay resides in the possibility of detection of sterically hindered primary amines.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
1, PEPTIDE COMBINATORIAL LIBRARIES, 4-BENZODIAZEPINE DERIVATIVES, MONITORING REACTIONS, DRUG DISCOVERY, ACID, CHEMISTRY, solid-phase peptide synthesis, Disperse Red, p-nitrophenyl ester
journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Eur. J. Org. Chem.
volume
11
pages
2787 - 2791
Web of Science type
Article
Web of Science id
000087007900011
ISSN
1434-193X
language
English
UGent publication?
yes
classification
A1
id
112146
handle
http://hdl.handle.net/1854/LU-112146
date created
2004-01-14 13:34:00
date last changed
2016-12-19 15:37:03
@article{112146,
  abstract     = {A new simple and efficient method for the detection of incomplete coupling reactions during solid-phase peptide synthesis is decribed. Using p-nitrophenyl ester 1 (NF31), free amino groups can be visually detected on the resin by direct coloring of the beads. A specific feature of the assay resides in the possibility of detection of sterically hindered primary amines.},
  author       = {Madder, Annemieke and Farcy, Nadia and Hosten, NGC and De Muynck, Hilde and De Clercq, Pierre and Barry, J and Davis, APA},
  issn         = {1434-193X},
  journal      = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY},
  keyword      = {1,PEPTIDE COMBINATORIAL LIBRARIES,4-BENZODIAZEPINE DERIVATIVES,MONITORING REACTIONS,DRUG DISCOVERY,ACID,CHEMISTRY,solid-phase peptide synthesis,Disperse Red,p-nitrophenyl ester},
  language     = {eng},
  pages        = {2787--2791},
  title        = {Novel sensitive colorimetric assay for visual detection of solid-phase bound amines},
  volume       = {11},
  year         = {1999},
}

Chicago
Madder, Annemieke, Nadia Farcy, NGC Hosten, Hilde De Muynck, Pierre De Clercq, J Barry, and APA Davis. 1999. “Novel Sensitive Colorimetric Assay for Visual Detection of Solid-phase Bound Amines.” European Journal of Organic Chemistry 11: 2787–2791.
APA
Madder, A., Farcy, N., Hosten, N., De Muynck, H., De Clercq, P., Barry, J., & Davis, A. (1999). Novel sensitive colorimetric assay for visual detection of solid-phase bound amines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 11, 2787–2791.
Vancouver
1.
Madder A, Farcy N, Hosten N, De Muynck H, De Clercq P, Barry J, et al. Novel sensitive colorimetric assay for visual detection of solid-phase bound amines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 1999;11:2787–91.
MLA
Madder, Annemieke, Nadia Farcy, NGC Hosten, et al. “Novel Sensitive Colorimetric Assay for Visual Detection of Solid-phase Bound Amines.” EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 11 (1999): 2787–2791. Print.