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Novel sensitive colorimetric assay for visual detection of solid-phase bound amines

Author
Organization
Abstract
A new simple and efficient method for the detection of incomplete coupling reactions during solid-phase peptide synthesis is decribed. Using p-nitrophenyl ester 1 (NF31), free amino groups can be visually detected on the resin by direct coloring of the beads. A specific feature of the assay resides in the possibility of detection of sterically hindered primary amines.
Keywords
1, PEPTIDE COMBINATORIAL LIBRARIES, 4-BENZODIAZEPINE DERIVATIVES, MONITORING REACTIONS, DRUG DISCOVERY, ACID, CHEMISTRY, solid-phase peptide synthesis, Disperse Red, p-nitrophenyl ester

Citation

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Chicago
Madder, Annemieke, Nadia Farcy, NGC Hosten, Hilde De Muynck, Pierre De Clercq, J Barry, and APA Davis. 1999. “Novel Sensitive Colorimetric Assay for Visual Detection of Solid-phase Bound Amines.” European Journal of Organic Chemistry 11: 2787–2791.
APA
Madder, A., Farcy, N., Hosten, N., De Muynck, H., De Clercq, P., Barry, J., & Davis, A. (1999). Novel sensitive colorimetric assay for visual detection of solid-phase bound amines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 11, 2787–2791.
Vancouver
1.
Madder A, Farcy N, Hosten N, De Muynck H, De Clercq P, Barry J, et al. Novel sensitive colorimetric assay for visual detection of solid-phase bound amines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 1999;11:2787–91.
MLA
Madder, Annemieke, Nadia Farcy, NGC Hosten, et al. “Novel Sensitive Colorimetric Assay for Visual Detection of Solid-phase Bound Amines.” EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 11 (1999): 2787–2791. Print.
@article{112146,
  abstract     = {A new simple and efficient method for the detection of incomplete coupling reactions during solid-phase peptide synthesis is decribed. Using p-nitrophenyl ester 1 (NF31), free amino groups can be visually detected on the resin by direct coloring of the beads. A specific feature of the assay resides in the possibility of detection of sterically hindered primary amines.},
  author       = {Madder, Annemieke and Farcy, Nadia and Hosten, NGC and De Muynck, Hilde and De Clercq, Pierre and Barry, J and Davis, APA},
  issn         = {1434-193X},
  journal      = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY},
  keyword      = {1,PEPTIDE COMBINATORIAL LIBRARIES,4-BENZODIAZEPINE DERIVATIVES,MONITORING REACTIONS,DRUG DISCOVERY,ACID,CHEMISTRY,solid-phase peptide synthesis,Disperse Red,p-nitrophenyl ester},
  language     = {eng},
  pages        = {2787--2791},
  title        = {Novel sensitive colorimetric assay for visual detection of solid-phase bound amines},
  volume       = {11},
  year         = {1999},
}

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