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Diagnosis and treatment of subclinical mastitis in early lactation in dairy goats

S McDougall, Karlien Supré UGent, Sarne De Vliegher UGent, Freddy Haesebrouck UGent, H Hussein, L Clausen and C Prosser (2010) JOURNAL OF DAIRY SCIENCE. 93(10). p.4710-4721
abstract
The objectives of the study were to define the sensitivity and specificity of the California Mastitis Test (CMT) in determining the presence of intramammary infection in postpartum dairy goats and to determine whether antibiotic therapy increased bacteriological cure rate and lowered somatic cell count (SCC) compared with untreated controls. A CMT was performed and milk samples were collected for bacteriology from 211 glands of 106 does between 0 and 10 d after kidding. From a population of 3,239 glands from goats in 4 commercial herds; goats with one or both glands with a CMT score of >1 and from which bacteria were isolated were either assigned to be treated with 3 intramammary infusions at 12-h intervals of 75 mg of sodium ampicillin and 250 mg of sodium cloxacillin (n = 57 glands) or left as untreated controls (n = 49 glands). Milk samples were collected again 14 +/- 3 and 21 +/- 3 d later for bacteriology and SCC determination. Composite milk yield, goat SCC, length of lactation, and survival data were collected. A partial budget was constructed to assess the cost effectiveness of treatment. At a cut point of greater than trace, the sensitivity, specificity, and positive and negative predictive values of the CMT were 0.74, 0.74, 0.42, and 0.92, respectively. Treatment increased the bacteriological cure rate compared with no treatment [30/57 (53%) vs. 6/49 (12%)], but there was a pathogen by treatment interaction whereby treatment increased cure proportion in glands infected with minor, but not major, pathogens. Treatment reduced the foremilk gland-level SCC [1,595 (95% CI = 1,106-2,300) vs. 3,028 (95% CI = 2,091-4,385) geometric mean (x 1,000) cells/mL] but not the SCC at goat level [1,596 (95% CI = 1,219-2,090) vs. 1,488 (95% CI = 1,132-1,955) geometric mean (x 1,000) cells/mL] compared with no treatment. Milk yield, risk of removal from the herd; and length of lactation were not altered by treatment. Treatment resulted in a loss of NZ$20.39/doe. It was concluded that use of the CMT as a screening test resulted in a higher likelihood of finding a gland that would be infected than selecting a gland at random. Treatment increased bacteriological cure rate and reduced SCC at gland level compared with no treatment. However; at goat level, milk yield, SCC, and survival were not altered, resulting in no economic benefit of treatment.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
COWS, YIELD, PREVALENCE, therapy, SOMATIC-CELL COUNT, STAPHYLOCOCCUS-AUREUS MASTITIS, CALIFORNIA MASTITIS, CLINICAL MASTITIS, MILK-PRODUCTION, PATHOGENS, INFECTION, diagnosis, subclinical mastitis, goat
journal title
JOURNAL OF DAIRY SCIENCE
J. Dairy Sci.
volume
93
issue
10
pages
4710 - 4721
Web of Science type
Article
Web of Science id
000282139900028
JCR category
AGRICULTURE, DAIRY & ANIMAL SCIENCE
JCR impact factor
2.497 (2010)
JCR rank
2/54 (2010)
JCR quartile
1 (2010)
ISSN
0022-0302
DOI
10.3168/jds.2010-3324
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1114012
handle
http://hdl.handle.net/1854/LU-1114012
date created
2011-02-01 14:56:29
date last changed
2011-02-18 12:01:00
@article{1114012,
  abstract     = {The objectives of the study were to define the sensitivity and specificity of the California Mastitis Test (CMT) in determining the presence of intramammary infection in postpartum dairy goats and to determine whether antibiotic therapy increased bacteriological cure rate and lowered somatic cell count (SCC) compared with untreated controls. A CMT was performed and milk samples were collected for bacteriology from 211 glands of 106 does between 0 and 10 d after kidding. From a population of 3,239 glands from goats in 4 commercial herds; goats with one or both glands with a CMT score of {\textrangle}1 and from which bacteria were isolated were either assigned to be treated with 3 intramammary infusions at 12-h intervals of 75 mg of sodium ampicillin and 250 mg of sodium cloxacillin (n = 57 glands) or left as untreated controls (n = 49 glands). Milk samples were collected again 14 +/- 3 and 21 +/- 3 d later for bacteriology and SCC determination. Composite milk yield, goat SCC, length of lactation, and survival data were collected. A partial budget was constructed to assess the cost effectiveness of treatment. At a cut point of greater than trace, the sensitivity, specificity, and positive and negative predictive values of the CMT were 0.74, 0.74, 0.42, and 0.92, respectively. Treatment increased the bacteriological cure rate compared with no treatment [30/57 (53\%) vs. 6/49 (12\%)], but there was a pathogen by treatment interaction whereby treatment increased cure proportion in glands infected with minor, but not major, pathogens. Treatment reduced the foremilk gland-level SCC [1,595 (95\% CI = 1,106-2,300) vs. 3,028 (95\% CI = 2,091-4,385) geometric mean (x 1,000) cells/mL] but not the SCC at goat level [1,596 (95\% CI = 1,219-2,090) vs. 1,488 (95\% CI = 1,132-1,955) geometric mean (x 1,000) cells/mL] compared with no treatment. Milk yield, risk of removal from the herd; and length of lactation were not altered by treatment. Treatment resulted in a loss of NZ\$20.39/doe. It was concluded that use of the CMT as a screening test resulted in a higher likelihood of finding a gland that would be infected than selecting a gland at random. Treatment increased bacteriological cure rate and reduced SCC at gland level compared with no treatment. However; at goat level, milk yield, SCC, and survival were not altered, resulting in no economic benefit of treatment.},
  author       = {McDougall, S and Supr{\'e}, Karlien and De Vliegher, Sarne and Haesebrouck, Freddy and Hussein, H and Clausen, L and Prosser, C},
  issn         = {0022-0302},
  journal      = {JOURNAL OF DAIRY SCIENCE},
  keyword      = {COWS,YIELD,PREVALENCE,therapy,SOMATIC-CELL COUNT,STAPHYLOCOCCUS-AUREUS MASTITIS,CALIFORNIA MASTITIS,CLINICAL MASTITIS,MILK-PRODUCTION,PATHOGENS,INFECTION,diagnosis,subclinical mastitis,goat},
  language     = {eng},
  number       = {10},
  pages        = {4710--4721},
  title        = {Diagnosis and treatment of subclinical mastitis in early lactation in dairy goats},
  url          = {http://dx.doi.org/10.3168/jds.2010-3324},
  volume       = {93},
  year         = {2010},
}

Chicago
McDougall, S, Karlien Supré, Sarne De Vliegher, Freddy Haesebrouck, H Hussein, L Clausen, and C Prosser. 2010. “Diagnosis and Treatment of Subclinical Mastitis in Early Lactation in Dairy Goats.” Journal of Dairy Science 93 (10): 4710–4721.
APA
McDougall, S., Supré, K., De Vliegher, S., Haesebrouck, F., Hussein, H., Clausen, L., & Prosser, C. (2010). Diagnosis and treatment of subclinical mastitis in early lactation in dairy goats. JOURNAL OF DAIRY SCIENCE, 93(10), 4710–4721.
Vancouver
1.
McDougall S, Supré K, De Vliegher S, Haesebrouck F, Hussein H, Clausen L, et al. Diagnosis and treatment of subclinical mastitis in early lactation in dairy goats. JOURNAL OF DAIRY SCIENCE. 2010;93(10):4710–21.
MLA
McDougall, S, Karlien Supré, Sarne De Vliegher, et al. “Diagnosis and Treatment of Subclinical Mastitis in Early Lactation in Dairy Goats.” JOURNAL OF DAIRY SCIENCE 93.10 (2010): 4710–4721. Print.