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Sequential changes in motor speech across a levodopa cycle in advanced Parkinson's disease

Miet De Letter UGent, John Van Borsel UGent, Paul Boon UGent, Marc De Bodt UGent, Ingeborg Dhooge UGent and Patrick Santens UGent (2010) INTERNATIONAL JOURNAL OF SPEECH-LANGUAGE PATHOLOGY. 12(5). p.405-413
abstract
Previous research has indicated that in Parkinson's disease (PD) some motor speech characteristics are changed by levodopa administration, while others are not. In advanced PD, the time course of these changes and the correlations with motor performance have not been sufficiently investigated. The purpose was to investigate the sequential changes of respiratory, articulatory, and phonatory speech characteristics across a levodopa drug cycle, using spirometry, acoustic, and motor speech analysis. Seven patients with advanced PD were included. All patients were evaluated sequentually at 15 minute intervals before and following levodopa intake. Data were analysed using repeated measures ANOVA and non-parametric analysis. Significant changes were found in motor function, vital capacity, and standard deviation of the diadochokinetic period. A trend was present for shimmer and frequency of the first formant. Significant inter-individual differences in the sequential changes were demonstrated for nearly all evaluated parameters. The conclusion is that, in advanced PD, the evaluation of speech characteristics at one moment after levodopa administration is not representative of an entire drug cycle and that an individualized evaluation of an entire drug cycle is warranted before initiation of a speech-language pathology program.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
motor speech, Parkinson's disease, levodopa, medication cycle, pharmacology, dysarthria, SUBTHALAMIC NUCLEUS STIMULATION, PONTINE BRAIN-STEM, L-DOPA, WORD INTELLIGIBILITY, SQUIRREL-MONKEY, DYSARTHRIA, VOCALIZATION, RESPIRATION, VARIABILITY, STABILITY
journal title
INTERNATIONAL JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
Int. J. Speech-Lang. Pathol.
volume
12
issue
5
pages
405 - 413
Web of Science type
Article
Web of Science id
000282403800004
JCR category
REHABILITATION
JCR impact factor
1.12 (2010)
JCR rank
28/61 (2010)
JCR quartile
2 (2010)
ISSN
1754-9507
DOI
10.3109/17549507.2010.491556
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1113023
handle
http://hdl.handle.net/1854/LU-1113023
date created
2011-01-31 15:48:14
date last changed
2011-02-07 14:11:57
@article{1113023,
  abstract     = {Previous research has indicated that in Parkinson's disease (PD) some motor speech characteristics are changed by levodopa administration, while others are not. In advanced PD, the time course of these changes and the correlations with motor performance have not been sufficiently investigated. The purpose was to investigate the sequential changes of respiratory, articulatory, and phonatory speech characteristics across a levodopa drug cycle, using spirometry, acoustic, and motor speech analysis. Seven patients with advanced PD were included. All patients were evaluated sequentually at 15 minute intervals before and following levodopa intake. Data were analysed using repeated measures ANOVA and non-parametric analysis. Significant changes were found in motor function, vital capacity, and standard deviation of the diadochokinetic period. A trend was present for shimmer and frequency of the first formant. Significant inter-individual differences in the sequential changes were demonstrated for nearly all evaluated parameters. The conclusion is that, in advanced PD, the evaluation of speech characteristics at one moment after levodopa administration is not representative of an entire drug cycle and that an individualized evaluation of an entire drug cycle is warranted before initiation of a speech-language pathology program.},
  author       = {De Letter, Miet and Van Borsel, John and Boon, Paul and De Bodt, Marc and Dhooge, Ingeborg and Santens, Patrick},
  issn         = {1754-9507},
  journal      = {INTERNATIONAL JOURNAL OF SPEECH-LANGUAGE PATHOLOGY},
  keyword      = {motor speech,Parkinson's disease,levodopa,medication cycle,pharmacology,dysarthria,SUBTHALAMIC NUCLEUS STIMULATION,PONTINE BRAIN-STEM,L-DOPA,WORD INTELLIGIBILITY,SQUIRREL-MONKEY,DYSARTHRIA,VOCALIZATION,RESPIRATION,VARIABILITY,STABILITY},
  language     = {eng},
  number       = {5},
  pages        = {405--413},
  title        = {Sequential changes in motor speech across a levodopa cycle in advanced Parkinson's disease},
  url          = {http://dx.doi.org/10.3109/17549507.2010.491556},
  volume       = {12},
  year         = {2010},
}

Chicago
De Letter, Miet, John Van Borsel, Paul Boon, Marc De Bodt, Ingeborg Dhooge, and Patrick Santens. 2010. “Sequential Changes in Motor Speech Across a Levodopa Cycle in Advanced Parkinson’s Disease.” International Journal of Speech-language Pathology 12 (5): 405–413.
APA
De Letter, M., Van Borsel, J., Boon, P., De Bodt, M., Dhooge, I., & Santens, P. (2010). Sequential changes in motor speech across a levodopa cycle in advanced Parkinson’s disease. INTERNATIONAL JOURNAL OF SPEECH-LANGUAGE PATHOLOGY, 12(5), 405–413.
Vancouver
1.
De Letter M, Van Borsel J, Boon P, De Bodt M, Dhooge I, Santens P. Sequential changes in motor speech across a levodopa cycle in advanced Parkinson’s disease. INTERNATIONAL JOURNAL OF SPEECH-LANGUAGE PATHOLOGY. 2010;12(5):405–13.
MLA
De Letter, Miet, John Van Borsel, Paul Boon, et al. “Sequential Changes in Motor Speech Across a Levodopa Cycle in Advanced Parkinson’s Disease.” INTERNATIONAL JOURNAL OF SPEECH-LANGUAGE PATHOLOGY 12.5 (2010): 405–413. Print.