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Variable time-delay estimation for anesthesia control during intensive care

Clara-Mihaela Ionescu (UGent) , Ramona Hodrea (UGent) and Robain De Keyser (UGent)
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Abstract
The presence of artifacts plays a crucial role in automatic sedation systems and may introduce variable time delays (TDs) in the closed-loop-control structures. This paper presents a successful procedure to estimate the varying TD of the bispectral index (BIS) monitor used in closed-loop control during intensive care. The TD estimation (TDE) is based on the cross-correlation analysis technique and the method is validated with real measured signals of propofol and BIS. Extended prediction self-adaptive control is used in combination with a Smith predictor to reduce the computational burden imposed by the variable TD. The conclusion is that an online TDE of the BIS monitor improves the performance of the closed-loop system for reference tracking, disturbance rejection, and overall stability.
Keywords
INDEX, PROPOFOL, Anesthesia control, cross-correlation analysis, dead-time compensation (DTC), intensive care unit, model-based predictive control (MPC), time-delay estimation (TDE)

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Citation

Please use this url to cite or link to this publication:

Chicago
Ionescu, Clara-Mihaela, Ramona Hodrea, and Robain De Keyser. 2011. “Variable Time-delay Estimation for Anesthesia Control During Intensive Care.” Ieee Transactions on Biomedical Engineering 58 (2): 363–369.
APA
Ionescu, C.-M., Hodrea, R., & De Keyser, R. (2011). Variable time-delay estimation for anesthesia control during intensive care. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 58(2), 363–369.
Vancouver
1.
Ionescu C-M, Hodrea R, De Keyser R. Variable time-delay estimation for anesthesia control during intensive care. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 2011;58(2):363–9.
MLA
Ionescu, Clara-Mihaela, Ramona Hodrea, and Robain De Keyser. “Variable Time-delay Estimation for Anesthesia Control During Intensive Care.” IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 58.2 (2011): 363–369. Print.
@article{1109843,
  abstract     = {The presence of artifacts plays a crucial role in automatic sedation systems and may introduce variable time delays (TDs) in the closed-loop-control structures. This paper presents a successful procedure to estimate the varying TD of the bispectral index (BIS) monitor used in closed-loop control during intensive care. The TD estimation (TDE) is based on the cross-correlation analysis technique and the method is validated with real measured signals of propofol and BIS. Extended prediction self-adaptive control is used in combination with a Smith predictor to reduce the computational burden imposed by the variable TD. The conclusion is that an online TDE of the BIS monitor improves the performance of the closed-loop system for reference tracking, disturbance rejection, and overall stability.},
  author       = {Ionescu, Clara-Mihaela and Hodrea, Ramona and De Keyser, Robain},
  issn         = {0018-9294},
  journal      = {IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING},
  keyword      = {INDEX,PROPOFOL,Anesthesia control,cross-correlation analysis,dead-time compensation (DTC),intensive care unit,model-based predictive control (MPC),time-delay estimation (TDE)},
  language     = {eng},
  number       = {2},
  pages        = {363--369},
  title        = {Variable time-delay estimation for anesthesia control during intensive care},
  url          = {http://dx.doi.org/10.1109/TBME.2010.2088121},
  volume       = {58},
  year         = {2011},
}

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