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Molecular cross-talk between nuclear receptors and nuclear factor-kB

Ilse Beck UGent, Guy Haegeman UGent and Karolien De Bosscher UGent (2010) From molecular to modular tumor therapy : tumors are reconstructible communicatively evolving systems. In The Tumor Microenvironment 3 (3). p.191-242
abstract
Abstract Nuclear receptors can function as ligand-activated transcription factors but can even so cross-talk with other transcription factors. In this respect, NF-kB, a central regulator of both inflammation and tumorigenesis, can cross-react with and is negatively affected by these nuclear receptors. In current medicine, the nuclear receptor ligands for the glucocorticoid receptor form still the mainstay for treatment of inflammation-based afflictions. However, also other nuclear receptor ligands can affect inflammatory processes. In this respect, the cross-talk of various nuclear receptors with each other has been given renewed attention in recent literature. We will discuss the cross-talk of nuclear receptors with NF-kB and each other in the context of the attenuating control of inflammatory and tumor-promoting mechanisms, using the well described glucocorticoid receptor as a focal point.
Please use this url to cite or link to this publication:
author
organization
year
type
bookChapter
publication status
published
subject
keyword
Inflammation, NF-kappaB, Nuclear receptor (NR), Cross-talk, Glucocorticoid receptor (GR), Peroxisome proliferator-activated receptor (PPAR), Estrogen receptor (ER), Androgen receptor (AR), Progesterone receptor, (PR), Liver X receptor (LXR), Vitamin D receptor (VDR), Orphan receptor
book title
From molecular to modular tumor therapy : tumors are reconstructible communicatively evolving systems
editor
Albrecht Reichle
series title
The Tumor Microenvironment
volume
3 (3)
pages
191 - 242
publisher
Springer
ISBN
9789048195305
DOI
10.1007/978-90-481-9531-2_10
language
English
UGent publication?
yes
classification
B2
copyright statement
I have transferred the copyright for this publication to the publisher
id
1107478
handle
http://hdl.handle.net/1854/LU-1107478
date created
2011-01-21 12:45:17
date last changed
2011-01-26 15:44:01
@incollection{1107478,
  abstract     = {Abstract Nuclear receptors can function as ligand-activated transcription factors but can even so cross-talk with other transcription factors. In this respect, NF-kB, a central regulator of both inflammation and tumorigenesis, can cross-react with and is negatively affected by these nuclear receptors. In current medicine, the nuclear receptor ligands for the glucocorticoid receptor form still the mainstay for treatment
of inflammation-based afflictions. However, also other nuclear receptor ligands can affect inflammatory processes. In this respect, the cross-talk of various nuclear receptors with each other has been given renewed attention in recent literature. We
will discuss the cross-talk of nuclear receptors with NF-kB and each other in the context of the attenuating control of inflammatory and tumor-promoting mechanisms, using the well described glucocorticoid receptor as a focal point.},
  author       = {Beck, Ilse and Haegeman, Guy and De Bosscher, Karolien},
  booktitle    = {From molecular to modular tumor therapy : tumors are reconstructible communicatively evolving systems},
  editor       = {Reichle, Albrecht},
  isbn         = {9789048195305},
  keyword      = {Inflammation,NF-kappaB,Nuclear receptor (NR),Cross-talk,Glucocorticoid receptor (GR),Peroxisome proliferator-activated receptor (PPAR),Estrogen receptor (ER),Androgen receptor (AR),Progesterone receptor,(PR),Liver X receptor (LXR),Vitamin D receptor (VDR),Orphan receptor},
  language     = {eng},
  pages        = {191--242},
  publisher    = {Springer},
  series       = {The Tumor Microenvironment},
  title        = {Molecular cross-talk between nuclear receptors and nuclear factor-kB},
  url          = {http://dx.doi.org/10.1007/978-90-481-9531-2\_10},
  volume       = {3 (3)},
  year         = {2010},
}

Chicago
Beck, Ilse, Guy Haegeman, and Karolien De Bosscher. 2010. “Molecular Cross-talk Between Nuclear Receptors and Nuclear factor-kB.” In From Molecular to Modular Tumor Therapy : Tumors Are Reconstructible Communicatively Evolving Systems, ed. Albrecht Reichle, 3 (3):191–242. Springer.
APA
Beck, I., Haegeman, G., & De Bosscher, K. (2010). Molecular cross-talk between nuclear receptors and nuclear factor-kB. In Albrecht Reichle (Ed.), From molecular to modular tumor therapy : tumors are reconstructible communicatively evolving systems (Vol. 3 (3), pp. 191–242). Springer.
Vancouver
1.
Beck I, Haegeman G, De Bosscher K. Molecular cross-talk between nuclear receptors and nuclear factor-kB. In: Reichle A, editor. From molecular to modular tumor therapy : tumors are reconstructible communicatively evolving systems. Springer; 2010. p. 191–242.
MLA
Beck, Ilse, Guy Haegeman, and Karolien De Bosscher. “Molecular Cross-talk Between Nuclear Receptors and Nuclear factor-kB.” From Molecular to Modular Tumor Therapy : Tumors Are Reconstructible Communicatively Evolving Systems. Ed. Albrecht Reichle. Vol. 3 (3). Springer, 2010. 191–242. Print.