Ghent University Academic Bibliography

Advanced

Case-control genome-wide association study of attention-deficit/hyperactivity disorder

Benjamin M Neale, Sarah Medland, Stephan Ripke, Richard JL Anney, Philip Asherson, Jan Buitelaar, Barbara Franke, Michael Gill, Lindsey Kent, Peter Holmans, et al. (2010) JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY. 49(9). p.906-920
abstract
Objective: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. Thus additional genomewide association studies (GWAS) are needed. Method: We used case-control analyses of 896 cases with DSM-IV ADHD genotvped using the Affymetrix 5.0 array and 2,455 repository controls screened for psychotic and bipolar symptoms genotyped using Affymetrix 6.0 arrays. A consensus SNP set was imputed using BEAGLE 3.0, resulting in an analysis dataset of 1,033,244 SNPs. Data were analyzed using a generalized linear model. Results: No genomewide significant associations were found. The most significant results implicated the following genes: PRKG1, FLNC, TCERG1L, PPM1H, NXPH1, PPM1H, CDH13, HK1, and HKDC1. Conclusions: The current analyses are a useful addition to the present literature and will make a valuable contribution to future meta-analyses. The candidate gene findings are consistent with a prior meta-analysis in suggesting that the effects of ADHD risk variants must, individually, be very small and/or include multiple rare alleles. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(9):906-920.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DEFICIT HYPERACTIVITY DISORDER, PROTEIN-KINASE-I, INTERNATIONAL HAPMAP PROJECT, SUBSTANCE USE DISORDERS, LONG-TERM POTENTIATION, MOLECULAR-GENETICS, SUSCEPTIBILITY LOCI, BIPOLAR DISORDER, COMMON VARIANTS, CANDIDATE GENES
journal title
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
J. Am. Acad. Child Adolesc. Psychiatr.
volume
49
issue
9
pages
906 - 920
Web of Science type
Article
Web of Science id
000281331400005
JCR category
PEDIATRICS
JCR impact factor
5.148 (2010)
JCR rank
2/105 (2010)
JCR quartile
1 (2010)
ISSN
0890-8567
DOI
10.1016/j.jaac.2010.06.007
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1107217
handle
http://hdl.handle.net/1854/LU-1107217
date created
2011-01-21 12:21:16
date last changed
2016-12-19 15:43:53
@article{1107217,
  abstract     = {Objective: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. Thus additional genomewide association studies (GWAS) are needed. Method: We used case-control analyses of 896 cases with DSM-IV ADHD genotvped using the Affymetrix 5.0 array and 2,455 repository controls screened for psychotic and bipolar symptoms genotyped using Affymetrix 6.0 arrays. A consensus SNP set was imputed using BEAGLE 3.0, resulting in an analysis dataset of 1,033,244 SNPs. Data were analyzed using a generalized linear model. Results: No genomewide significant associations were found. The most significant results implicated the following genes: PRKG1, FLNC, TCERG1L, PPM1H, NXPH1, PPM1H, CDH13, HK1, and HKDC1. Conclusions: The current analyses are a useful addition to the present literature and will make a valuable contribution to future meta-analyses. The candidate gene findings are consistent with a prior meta-analysis in suggesting that the effects of ADHD risk variants must, individually, be very small and/or include multiple rare alleles. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(9):906-920.},
  author       = {Neale, Benjamin M and Medland, Sarah and Ripke, Stephan and Anney, Richard JL and Asherson, Philip and Buitelaar, Jan and Franke, Barbara and Gill, Michael and Kent, Lindsey and Holmans, Peter and Middleton, Frank and Thapar, Anita and Lesch, Klaus-Peter and Faraone, Stephen V and Daly, Mark and Nguyen, Thuy Trang and Schaefer, Helmut and Steinhausen, Hans-Christoph and Reif, Andreas and Renner, Tobias J and Romanos, Marcel and Romanos, Jasmin and Warnke, Andreas and Walitza, Susanne and Freitag, Christine and Meyer, Jobst and Palmason, Haukur and Rothenberger, Aribert and Hawi, Ziarih and Sergeant, Joseph and Roeyers, Herbert and Mick, Eric and Biederman, Jospeh},
  issn         = {0890-8567},
  journal      = {JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY},
  keyword      = {DEFICIT HYPERACTIVITY DISORDER,PROTEIN-KINASE-I,INTERNATIONAL HAPMAP PROJECT,SUBSTANCE USE DISORDERS,LONG-TERM POTENTIATION,MOLECULAR-GENETICS,SUSCEPTIBILITY LOCI,BIPOLAR DISORDER,COMMON VARIANTS,CANDIDATE GENES},
  language     = {eng},
  number       = {9},
  pages        = {906--920},
  title        = {Case-control genome-wide association study of attention-deficit/hyperactivity disorder},
  url          = {http://dx.doi.org/10.1016/j.jaac.2010.06.007},
  volume       = {49},
  year         = {2010},
}

Chicago
Neale, Benjamin M, Sarah Medland, Stephan Ripke, Richard JL Anney, Philip Asherson, Jan Buitelaar, Barbara Franke, et al. 2010. “Case-control Genome-wide Association Study of Attention-deficit/hyperactivity Disorder.” Journal of the American Academy of Child and Adolescent Psychiatry 49 (9): 906–920.
APA
Neale, B. M., Medland, S., Ripke, S., Anney, R. J., Asherson, P., Buitelaar, J., Franke, B., et al. (2010). Case-control genome-wide association study of attention-deficit/hyperactivity disorder. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 49(9), 906–920.
Vancouver
1.
Neale BM, Medland S, Ripke S, Anney RJ, Asherson P, Buitelaar J, et al. Case-control genome-wide association study of attention-deficit/hyperactivity disorder. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY. 2010;49(9):906–20.
MLA
Neale, Benjamin M, Sarah Medland, Stephan Ripke, et al. “Case-control Genome-wide Association Study of Attention-deficit/hyperactivity Disorder.” JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY 49.9 (2010): 906–920. Print.