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In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability

Gabriele Gross, Doris M Jacobs, Sonja Peters, Sam Possemiers, John van Duynhoven, Elaine E Vaughan and Tom Van de Wiele UGent (2010) JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 58(18). p.10236-10246
abstract
Dietary polyphenols in tea and wine have been associated with beneficial health effects. After ingestion, most polyphenols are metabolized by the colonic microbiota. The current study aimed at exploring the interindividual variation of gut microbial polyphenol bioconversion from 10 healthy human subjects. In vitro fecal batch fermentations simulating conditions in the distal colon were performed using polyphenols from black tea and a mixture of red wine and grape juice. Microbial bioconversion was monitored by NMR- and GC-MS-based profiling of diverse metabolites and phenolics. The complex polyphenol mixtures were degraded to a limited number of key metabolites. Each subject displayed a specific metabolite profile differing in composition and time courses as well as levels of these metabolites. Moreover, clear differences depending on the polyphenol sources were observed. In conclusion, varying metabolite pathways among individuals result in different metabolome profiles and therefore related health effects are hypothesized to differ between subjects.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CHAIN FATTY-ACIDS, DIETARY POLYPHENOLS, ANAEROBIC DEGRADATION, FERMENTATION PRODUCTS, COLONIC FERMENTATION, HUMAN HEALTH, METABOLISM, BACTERIA, TRACT, RATS
journal title
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
J. Agric. Food Chem.
volume
58
issue
18
pages
10236 - 10246
Web of Science type
Article
Web of Science id
000281736000051
JCR category
AGRICULTURE, MULTIDISCIPLINARY
JCR impact factor
2.816 (2010)
JCR rank
2/55 (2010)
JCR quartile
1 (2010)
ISSN
0021-8561
DOI
10.1021/jf101475m
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1107011
handle
http://hdl.handle.net/1854/LU-1107011
date created
2011-01-21 11:55:55
date last changed
2016-12-19 15:41:08
@article{1107011,
  abstract     = {Dietary polyphenols in tea and wine have been associated with beneficial health effects. After ingestion, most polyphenols are metabolized by the colonic microbiota. The current study aimed at exploring the interindividual variation of gut microbial polyphenol bioconversion from 10 healthy human subjects. In vitro fecal batch fermentations simulating conditions in the distal colon were performed using polyphenols from black tea and a mixture of red wine and grape juice. Microbial bioconversion was monitored by NMR- and GC-MS-based profiling of diverse metabolites and phenolics. The complex polyphenol mixtures were degraded to a limited number of key metabolites. Each subject displayed a specific metabolite profile differing in composition and time courses as well as levels of these metabolites. Moreover, clear differences depending on the polyphenol sources were observed. In conclusion, varying metabolite pathways among individuals result in different metabolome profiles and therefore related health effects are hypothesized to differ between subjects.},
  author       = {Gross, Gabriele and Jacobs, Doris M and Peters, Sonja and Possemiers, Sam and van Duynhoven, John and Vaughan, Elaine E and Van de Wiele, Tom},
  issn         = {0021-8561},
  journal      = {JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY},
  keyword      = {CHAIN FATTY-ACIDS,DIETARY POLYPHENOLS,ANAEROBIC DEGRADATION,FERMENTATION PRODUCTS,COLONIC FERMENTATION,HUMAN HEALTH,METABOLISM,BACTERIA,TRACT,RATS},
  language     = {eng},
  number       = {18},
  pages        = {10236--10246},
  title        = {In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability},
  url          = {http://dx.doi.org/10.1021/jf101475m},
  volume       = {58},
  year         = {2010},
}

Chicago
Gross, Gabriele, Doris M Jacobs, Sonja Peters, Sam Possemiers, John van Duynhoven, Elaine E Vaughan, and Tom Van de Wiele. 2010. “In Vitro Bioconversion of Polyphenols from Black Tea and Red Wine/grape Juice by Human Intestinal Microbiota Displays Strong Interindividual Variability.” Journal of Agricultural and Food Chemistry 58 (18): 10236–10246.
APA
Gross, Gabriele, Jacobs, D. M., Peters, S., Possemiers, S., van Duynhoven, J., Vaughan, E. E., & Van de Wiele, T. (2010). In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 58(18), 10236–10246.
Vancouver
1.
Gross G, Jacobs DM, Peters S, Possemiers S, van Duynhoven J, Vaughan EE, et al. In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2010;58(18):10236–46.
MLA
Gross, Gabriele, Doris M Jacobs, Sonja Peters, et al. “In Vitro Bioconversion of Polyphenols from Black Tea and Red Wine/grape Juice by Human Intestinal Microbiota Displays Strong Interindividual Variability.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58.18 (2010): 10236–10246. Print.