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Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities

Robèr A Kemperman, Selin Bolca UGent, Laure C Roger and Elaine E Vaughan (2010) MICROBIOLOGY-SGM. 156(11). p.3224-3231
abstract
Polyphenols, ubiquitously present in the food we consume, may modify the gut microbial composition and/or activity, and moreover, may be converted by the colonic microbiota to bioactive compounds that influence host health. The polyphenol content of fruit and vegetables and derived products is implicated in some of the health benefits bestowed on eating fruit and vegetables. Elucidating the mechanisms behind polyphenol metabolism is an important step in understanding their health effects. Yet, this is no trivial assignment due to the diversity encountered in both polyphenols and the gut microbial composition, which is further confounded by the interactions with the host. Only a limited number of studies have investigated the impact of dietary polyphenols on the complex human gut microbiota and these were mainly focused on single polyphenol molecules and selected bacterial populations. Our knowledge of gut microbial genes and pathways for polyphenol bioconversion and interactions is poor. Application of specific in vitro or in vivo models mimicking the human gut environment is required to analyse these diverse interactions. A particular benefit can now be gained from next-generation analytical tools such as metagenomics and metatranscriptomics allowing a wider, more holistic approach to the analysis of polyphenol metabolism. Understanding the polyphenol gut microbiota interactions and gut microbial bioconversion capacity will facilitate studies on bioavailability of polyphenols in the host, provide more insight into the health effects of polyphenols and potentially open avenues for modulation of polyphenol bioactivity for host health.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
IN-VITRO, METABOLISM, RED WINE, F344 RATS, HUMAN HEALTH, EPIGALLOCATECHIN GALLATE, EUBACTERIUM-RAMULUS, MICROFLORA, EXPRESSION, BACTERIA
journal title
MICROBIOLOGY-SGM
Microbiology-(UK)
volume
156
issue
11
pages
3224 - 3231
Web of Science type
Review
Web of Science id
000284660400004
JCR category
MICROBIOLOGY
JCR impact factor
2.957 (2010)
JCR rank
39/103 (2010)
JCR quartile
2 (2010)
ISSN
1350-0872
DOI
10.1099/mic.0.042127-0
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1106381
handle
http://hdl.handle.net/1854/LU-1106381
date created
2011-01-20 16:12:19
date last changed
2016-12-19 15:46:30
@article{1106381,
  abstract     = {Polyphenols, ubiquitously present in the food we consume, may modify the gut microbial composition and/or activity, and moreover, may be converted by the colonic microbiota to bioactive compounds that influence host health. The polyphenol content of fruit and vegetables and derived products is implicated in some of the health benefits bestowed on eating fruit and vegetables. Elucidating the mechanisms behind polyphenol metabolism is an important step in understanding their health effects. Yet, this is no trivial assignment due to the diversity encountered in both polyphenols and the gut microbial composition, which is further confounded by the interactions with the host. Only a limited number of studies have investigated the impact of dietary polyphenols on the complex human gut microbiota and these were mainly focused on single polyphenol molecules and selected bacterial populations. Our knowledge of gut microbial genes and pathways for polyphenol bioconversion and interactions is poor. Application of specific in vitro or in vivo models mimicking the human gut environment is required to analyse these diverse interactions. A particular benefit can now be gained from next-generation analytical tools such as metagenomics and metatranscriptomics allowing a wider, more holistic approach to the analysis of polyphenol metabolism. Understanding the polyphenol gut microbiota interactions and gut microbial bioconversion capacity will facilitate studies on bioavailability of polyphenols in the host, provide more insight into the health effects of polyphenols and potentially open avenues for modulation of polyphenol bioactivity for host health.},
  author       = {Kemperman, Rob{\`e}r A and Bolca, Selin and Roger, Laure C and Vaughan, Elaine E},
  issn         = {1350-0872},
  journal      = {MICROBIOLOGY-SGM},
  keyword      = {IN-VITRO,METABOLISM,RED WINE,F344 RATS,HUMAN HEALTH,EPIGALLOCATECHIN GALLATE,EUBACTERIUM-RAMULUS,MICROFLORA,EXPRESSION,BACTERIA},
  language     = {eng},
  number       = {11},
  pages        = {3224--3231},
  title        = {Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities},
  url          = {http://dx.doi.org/10.1099/mic.0.042127-0},
  volume       = {156},
  year         = {2010},
}

Chicago
Kemperman, Robèr A, Selin Bolca, Laure C Roger, and Elaine E Vaughan. 2010. “Novel Approaches for Analysing Gut Microbes and Dietary Polyphenols: Challenges and Opportunities.” Microbiology-sgm 156 (11): 3224–3231.
APA
Kemperman, Robèr A, Bolca, S., Roger, L. C., & Vaughan, E. E. (2010). Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities. MICROBIOLOGY-SGM, 156(11), 3224–3231.
Vancouver
1.
Kemperman RA, Bolca S, Roger LC, Vaughan EE. Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities. MICROBIOLOGY-SGM. 2010;156(11):3224–31.
MLA
Kemperman, Robèr A, Selin Bolca, Laure C Roger, et al. “Novel Approaches for Analysing Gut Microbes and Dietary Polyphenols: Challenges and Opportunities.” MICROBIOLOGY-SGM 156.11 (2010): 3224–3231. Print.