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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Andre Franke, Dermot PB McGovern, Jeffrey C Barrett, Kai Wang, Graham L Radford-Smith, Tariq Ahmad, Charlie W Lees, Tobias Balschun, James Lee and Rebecca Roberts, et al. (2010) NATURE GENETICS. 42(12). p.1118-1125
abstract
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 x 10(-8)). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (letterNote)
publication status
published
subject
keyword
GENE, IDENTIFICATION, ASSOCIATION, NEDD4 FAMILY, COMMON VARIANTS, INFLAMMATORY-BOWEL-DISEASE, SEQUENCE VARIANTS, RECEPTOR, PROTEIN, ACTIVATION
journal title
NATURE GENETICS
Nature Genet.
volume
42
issue
12
pages
1118 - 1125
Web of Science type
Letter
Web of Science id
000284578800016
JCR category
GENETICS & HEREDITY
JCR impact factor
36.377 (2010)
JCR rank
1/154 (2010)
JCR quartile
1 (2010)
ISSN
1061-4036
DOI
10.1038/ng.717
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1098199
handle
http://hdl.handle.net/1854/LU-1098199
date created
2011-01-11 15:32:12
date last changed
2014-07-01 10:41:33
@article{1098199,
  abstract     = {We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P {\textlangle} 5 x 10(-8)). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.},
  author       = {Franke, Andre and McGovern, Dermot PB and Barrett, Jeffrey C and Wang, Kai and Radford-Smith, Graham L and Ahmad, Tariq and Lees, Charlie W and Balschun, Tobias and Lee, James and Roberts, Rebecca and Anderson, Carl A and Bis, Joshua C and Bumpstead, Suzanne and Ellinghaus, David and Festen, Eleonora M and Georges, Michel and Green, Todd and Haritunians, Talin and Jostins, Luke and Latiano, Anna and Mathew, Christopher G and Montgomery, Grant W and Prescott, Natalie J and Raychaudhuri, Soumya and Rotter, Jerome I and Schumm, Philip and Sharma, Yashoda and Simms, Lisa A and Taylor, Kent D and Whiteman, David and Wijmenga, Cisca and Baldassano, Robert N and Barclay, Murray and Bayless, Theodore M and Brand, Stephan and B{\"u}ning, Carsten and Cohen, Albert and Colombel, Jean-Frederick and Cottone, Mario and Stronati, Laura and Denson, Ted and DE VOS, MARTINE and D'Inca, Renata and Dubinsky, Marla and Edwards, Cathryn and Florin, Tim and Franchimont, Denis and Gearry, Richard and Glas, J{\"u}rgen and Van Gossum, Andre and Guthery, Stephen L and Halfvarson, Jonas and Verspaget, Hein W and Hugot, Jean-Pierre and Karban, Amir and Laukens, Debby and Lawrance, Ian and Lemann, Marc and Levine, Arie and Libioulle, Cecile and Louis, Edouard and Mowat, Craig and Newman, William and Pan{\'e}s, Juli{\'a}n and Phillips, Anne and Proctor, Deborah D and Regueiro, Miguel and Russell, Richard and Rutgeerts, Paul and Sanderson, Jeremy and Sans, Miquel and Seibold, Frank and Steinhart, A Hillary and Stokkers, Pieter CF and Torkvist, Leif and Kullak-Ublick, Gerd and Wilson, David and Walters, Thomas and Targan, Stephan R and Brant, Steven R and Rioux, John D and D'Amato, Mauro and Weersma, Rinse K and Kugathasan, Subra and Griffiths, Anne M and Mansfield, John C and Vermeire, Severine and Duerr, Richard H and Silverberg, Mark S and Satsangi, Jack and Schreiber, Stefan and Cho, Judy H and Annese, Vito and Hakonarson, Hakon and Daly, Mark J and Parkes, Miles},
  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  keyword      = {GENE,IDENTIFICATION,ASSOCIATION,NEDD4 FAMILY,COMMON VARIANTS,INFLAMMATORY-BOWEL-DISEASE,SEQUENCE VARIANTS,RECEPTOR,PROTEIN,ACTIVATION},
  language     = {eng},
  number       = {12},
  pages        = {1118--1125},
  title        = {Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci},
  url          = {http://dx.doi.org/10.1038/ng.717},
  volume       = {42},
  year         = {2010},
}

Chicago
Franke, Andre, Dermot PB McGovern, Jeffrey C Barrett, Kai Wang, Graham L Radford-Smith, Tariq Ahmad, Charlie W Lees, et al. 2010. “Genome-wide Meta-analysis Increases to 71 the Number of Confirmed Crohn’s Disease Susceptibility Loci.” Nature Genetics 42 (12): 1118–1125.
APA
Franke, A., McGovern, D. P., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., et al. (2010). Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci. NATURE GENETICS, 42(12), 1118–1125.
Vancouver
1.
Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci. NATURE GENETICS. 2010;42(12):1118–25.
MLA
Franke, Andre, Dermot PB McGovern, Jeffrey C Barrett, et al. “Genome-wide Meta-analysis Increases to 71 the Number of Confirmed Crohn’s Disease Susceptibility Loci.” NATURE GENETICS 42.12 (2010): 1118–1125. Print.