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The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications

(2010) FASEB JOURNAL. 24(11). p.4153-4166
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Abstract
The N-myc downstream regulated gene (NDRG) family of proteins consists of 4 members, NDRG1-4, which are well conserved through evolution. The first member to be discovered and responsible for the family name was NDRG1, because its expression is repressed by the proto-oncogenes MYCN and MYC. All family members are characterized by an alpha/beta hydrolase-fold motif; however, the precise molecular and cellular function of these family members has not been fully elucidated. Although the exact function of NDRG family members has not been clearly elucidated, emerging evidence suggests that mutations in these genes are associated with diverse neurological and electrophysiological syndromes. In addition, aberrant expression as well as tumor suppressor and oncogenic functions affecting key hallmarks of carcinogenesis such as cell proliferation, differentiation, migration, invasion, and stress response have been reported for several of the NDRG proteins. In this review, we summarize the current literature on the NDRG family members concerning their structure, origin, and tissue distribution. In addition, we review the current knowledge regarding the regulation and signaling of the NDRG family members in development and normal physiology. Finally, their role in disease and potential clinical applications (their role as detection or prognostic markers) are discussed
Keywords
proliferation, differentiation, stress response, cancer, biomarker, METASTASIS-SUPPRESSOR GENE, SQUAMOUS-CELL CARCINOMA, TERM HUMAN TROPHOBLASTS, DIFFERENTIALLY EXPRESSED GENES, HUMAN COLON-CARCINOMA, SENSORY NEUROPATHY-LOM, QT INTERVAL DURATION, BREAST-CANCER, TUMOR-METASTASIS, DOWN-REGULATION

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Citation

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Chicago
Melotte, Veerle, Xianghu Qu, Maté Ongenaert, Wim Van Criekinge, Adriaan P de Bruine, H Scott Baldwin, and Manon van Engeland. 2010. “The N-myc Downstream Regulated Gene (NDRG) Family: Diverse Functions, Multiple Applications.” Faseb Journal 24 (11): 4153–4166.
APA
Melotte, V., Qu, X., Ongenaert, M., Van Criekinge, W., de Bruine, A. P., Baldwin, H. S., & van Engeland, M. (2010). The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications. FASEB JOURNAL, 24(11), 4153–4166.
Vancouver
1.
Melotte V, Qu X, Ongenaert M, Van Criekinge W, de Bruine AP, Baldwin HS, et al. The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications. FASEB JOURNAL. 2010;24(11):4153–66.
MLA
Melotte, Veerle, Xianghu Qu, Maté Ongenaert, et al. “The N-myc Downstream Regulated Gene (NDRG) Family: Diverse Functions, Multiple Applications.” FASEB JOURNAL 24.11 (2010): 4153–4166. Print.
@article{1096196,
  abstract     = {The N-myc downstream regulated gene (NDRG) family of proteins consists of 4 members, NDRG1-4, which are well conserved through evolution. The first member to be discovered and responsible for the family name was NDRG1, because its expression is repressed by the proto-oncogenes MYCN and MYC. All family members are characterized by an alpha/beta hydrolase-fold motif; however, the precise molecular and cellular function of these family members has not been fully elucidated. Although the exact function of NDRG family members has not been clearly elucidated, emerging evidence suggests that mutations in these genes are associated with diverse neurological and electrophysiological syndromes. In addition, aberrant expression as well as tumor suppressor and oncogenic functions affecting key hallmarks of carcinogenesis such as cell proliferation, differentiation, migration, invasion, and stress response have been reported for several of the NDRG proteins. In this review, we summarize the current literature on the NDRG family members concerning their structure, origin, and tissue distribution. In addition, we review the current knowledge regarding the regulation and signaling of the NDRG family members in development and normal physiology. Finally, their role in disease and potential clinical applications (their role as detection or prognostic markers) are discussed},
  author       = {Melotte, Veerle and Qu, Xianghu and Ongenaert, Mat{\'e} and Van Criekinge, Wim and de Bruine, Adriaan P and Baldwin, H Scott and van Engeland, Manon},
  issn         = {0892-6638},
  journal      = {FASEB JOURNAL},
  keyword      = {proliferation,differentiation,stress response,cancer,biomarker,METASTASIS-SUPPRESSOR GENE,SQUAMOUS-CELL CARCINOMA,TERM HUMAN TROPHOBLASTS,DIFFERENTIALLY EXPRESSED GENES,HUMAN COLON-CARCINOMA,SENSORY NEUROPATHY-LOM,QT INTERVAL DURATION,BREAST-CANCER,TUMOR-METASTASIS,DOWN-REGULATION},
  language     = {eng},
  number       = {11},
  pages        = {4153--4166},
  title        = {The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications},
  url          = {http://dx.doi.org/10.1096/fj.09-151464},
  volume       = {24},
  year         = {2010},
}

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