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The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications

Veerle Melotte, Xianghu Qu, Maté Ongenaert UGent, Wim Van Criekinge UGent, Adriaan P de Bruine, H Scott Baldwin and Manon van Engeland (2010) FASEB JOURNAL. 24(11). p.4153-4166
abstract
The N-myc downstream regulated gene (NDRG) family of proteins consists of 4 members, NDRG1-4, which are well conserved through evolution. The first member to be discovered and responsible for the family name was NDRG1, because its expression is repressed by the proto-oncogenes MYCN and MYC. All family members are characterized by an alpha/beta hydrolase-fold motif; however, the precise molecular and cellular function of these family members has not been fully elucidated. Although the exact function of NDRG family members has not been clearly elucidated, emerging evidence suggests that mutations in these genes are associated with diverse neurological and electrophysiological syndromes. In addition, aberrant expression as well as tumor suppressor and oncogenic functions affecting key hallmarks of carcinogenesis such as cell proliferation, differentiation, migration, invasion, and stress response have been reported for several of the NDRG proteins. In this review, we summarize the current literature on the NDRG family members concerning their structure, origin, and tissue distribution. In addition, we review the current knowledge regarding the regulation and signaling of the NDRG family members in development and normal physiology. Finally, their role in disease and potential clinical applications (their role as detection or prognostic markers) are discussed
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
proliferation, differentiation, stress response, cancer, biomarker, METASTASIS-SUPPRESSOR GENE, SQUAMOUS-CELL CARCINOMA, TERM HUMAN TROPHOBLASTS, DIFFERENTIALLY EXPRESSED GENES, HUMAN COLON-CARCINOMA, SENSORY NEUROPATHY-LOM, QT INTERVAL DURATION, BREAST-CANCER, TUMOR-METASTASIS, DOWN-REGULATION
journal title
FASEB JOURNAL
Faseb J.
volume
24
issue
11
pages
4153 - 4166
Web of Science type
Review
Web of Science id
000283861100003
JCR category
BIOLOGY
JCR impact factor
6.515 (2010)
JCR rank
3/84 (2010)
JCR quartile
1 (2010)
ISSN
0892-6638
DOI
10.1096/fj.09-151464
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1096196
handle
http://hdl.handle.net/1854/LU-1096196
date created
2011-01-10 11:02:27
date last changed
2016-12-19 15:46:18
@article{1096196,
  abstract     = {The N-myc downstream regulated gene (NDRG) family of proteins consists of 4 members, NDRG1-4, which are well conserved through evolution. The first member to be discovered and responsible for the family name was NDRG1, because its expression is repressed by the proto-oncogenes MYCN and MYC. All family members are characterized by an alpha/beta hydrolase-fold motif; however, the precise molecular and cellular function of these family members has not been fully elucidated. Although the exact function of NDRG family members has not been clearly elucidated, emerging evidence suggests that mutations in these genes are associated with diverse neurological and electrophysiological syndromes. In addition, aberrant expression as well as tumor suppressor and oncogenic functions affecting key hallmarks of carcinogenesis such as cell proliferation, differentiation, migration, invasion, and stress response have been reported for several of the NDRG proteins. In this review, we summarize the current literature on the NDRG family members concerning their structure, origin, and tissue distribution. In addition, we review the current knowledge regarding the regulation and signaling of the NDRG family members in development and normal physiology. Finally, their role in disease and potential clinical applications (their role as detection or prognostic markers) are discussed},
  author       = {Melotte, Veerle and Qu, Xianghu and Ongenaert, Mat{\'e} and Van Criekinge, Wim and de Bruine, Adriaan P and Baldwin, H Scott and van Engeland, Manon},
  issn         = {0892-6638},
  journal      = {FASEB JOURNAL},
  keyword      = {proliferation,differentiation,stress response,cancer,biomarker,METASTASIS-SUPPRESSOR GENE,SQUAMOUS-CELL CARCINOMA,TERM HUMAN TROPHOBLASTS,DIFFERENTIALLY EXPRESSED GENES,HUMAN COLON-CARCINOMA,SENSORY NEUROPATHY-LOM,QT INTERVAL DURATION,BREAST-CANCER,TUMOR-METASTASIS,DOWN-REGULATION},
  language     = {eng},
  number       = {11},
  pages        = {4153--4166},
  title        = {The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications},
  url          = {http://dx.doi.org/10.1096/fj.09-151464},
  volume       = {24},
  year         = {2010},
}

Chicago
Melotte, Veerle, Xianghu Qu, Maté Ongenaert, Wim Van Criekinge, Adriaan P de Bruine, H Scott Baldwin, and Manon van Engeland. 2010. “The N-myc Downstream Regulated Gene (NDRG) Family: Diverse Functions, Multiple Applications.” Faseb Journal 24 (11): 4153–4166.
APA
Melotte, V., Qu, X., Ongenaert, M., Van Criekinge, W., de Bruine, A. P., Baldwin, H. S., & van Engeland, M. (2010). The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications. FASEB JOURNAL, 24(11), 4153–4166.
Vancouver
1.
Melotte V, Qu X, Ongenaert M, Van Criekinge W, de Bruine AP, Baldwin HS, et al. The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications. FASEB JOURNAL. 2010;24(11):4153–66.
MLA
Melotte, Veerle, Xianghu Qu, Maté Ongenaert, et al. “The N-myc Downstream Regulated Gene (NDRG) Family: Diverse Functions, Multiple Applications.” FASEB JOURNAL 24.11 (2010): 4153–4166. Print.