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Reliability of the qualitative and semiquantitative nailfold videocapillaroscopy assessment in a systemic sclerosis cohort: a two-centre study

Vanessa Smith UGent, Carmen Pizzorni, Filip De Keyser UGent, Saskia Decuman UGent, JENS VAN PRAET UGent, Ellen Deschepper UGent, Alberto Sulli and Maurizio Cutolo (2010) ANNALS OF THE RHEUMATIC DISEASES. 69(6). p.1092-1096
abstract
Objective Investigation of the reliability of the qualitative and semiquantitative scoring of nailfold videocapillaroscopy (NVC) assessment between two raters in a systemic sclerosis (SSc) cohort. Methods Two raters from different centres blindly assessed the NVC images of 71 consecutive patients with SSc qualitatively as belonging to the scleroderma spectrum (SDS) category ('early', 'active', 'late' scleroderma pattern or 'scleroderma-like' pattern) or to the 'normal' category and semiquantitatively by calculating the mean score for capillary loss, giant capillaries, microhaemorrhages and capillary ramifications. Inter-rater/intrarater agreement was assessed by calculation of the proportion of agreement and by. coefficients. Rater agreement of mean score values of hallmark parameters was assessed by intraclass correlation coefficients. Results The inter-rater/intrarater proportion of agreement to qualitatively assess an image as belonging to the SDS category or not was 90% and 96%, whereas the agreement to distinguish between only 'early', 'active' and 'late' scleroderma NVC patterns was 62% and 81%. The agreement of the semiquantitative scoring, as assessed by intraclass correlation coefficient, was 0.96 and 0.95 for capillary loss, 0.84 and 0.95 for giant capillaries, 0.90 and 0.95 for microhaemorrhages and 0.64 and 0.95 for capillary ramifications. Conclusions This is the first study to demonstrate reliability of the qualitative and semiquantitative NVC assessment in an SSc cohort between raters at different centres. Reliability of NVC assessment is essential for use of this tool in multicentre SSc trials.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CAPILLARY MICROSCOPY, MICROVASCULAR DAMAGE, CONNECTIVE-TISSUE DISEASE, LUPUS-ERYTHEMATOSUS, RAYNAUDS-PHENOMENON, SCLERODERMA, PATTERNS, AUTOANTIBODIES, CLASSIFICATION, DISORDERS
journal title
ANNALS OF THE RHEUMATIC DISEASES
Ann. Rheum. Dis.
volume
69
issue
6
pages
1092 - 1096
Web of Science type
Article
Web of Science id
000278017700024
JCR category
RHEUMATOLOGY
JCR impact factor
9.082 (2010)
JCR rank
1/29 (2010)
JCR quartile
1 (2010)
ISSN
0003-4967
DOI
10.1136/ard.2009.115568
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1095717
handle
http://hdl.handle.net/1854/LU-1095717
date created
2011-01-07 13:59:53
date last changed
2011-01-10 13:24:21
@article{1095717,
  abstract     = {Objective Investigation of the reliability of the qualitative and semiquantitative scoring of nailfold videocapillaroscopy (NVC) assessment between two raters in a systemic sclerosis (SSc) cohort.
Methods Two raters from different centres blindly assessed the NVC images of 71 consecutive patients with SSc qualitatively as belonging to the scleroderma spectrum (SDS) category ('early', 'active', 'late' scleroderma pattern or 'scleroderma-like' pattern) or to the 'normal' category and semiquantitatively by calculating the mean score for capillary loss, giant capillaries, microhaemorrhages and capillary ramifications. Inter-rater/intrarater agreement was assessed by calculation of the proportion of agreement and by. coefficients. Rater agreement of mean score values of hallmark parameters was assessed by intraclass correlation coefficients.
Results The inter-rater/intrarater proportion of agreement to qualitatively assess an image as belonging to the SDS category or not was 90\% and 96\%, whereas the agreement to distinguish between only 'early', 'active' and 'late' scleroderma NVC patterns was 62\% and 81\%. The agreement of the semiquantitative scoring, as assessed by intraclass correlation coefficient, was 0.96 and 0.95 for capillary loss, 0.84 and 0.95 for giant capillaries, 0.90 and 0.95 for microhaemorrhages and 0.64 and 0.95 for capillary ramifications.
Conclusions This is the first study to demonstrate reliability of the qualitative and semiquantitative NVC assessment in an SSc cohort between raters at different centres. Reliability of NVC assessment is essential for use of this tool in multicentre SSc trials.},
  author       = {Smith, Vanessa and Pizzorni, Carmen and De Keyser, Filip and Decuman, Saskia and VAN PRAET, JENS and Deschepper, Ellen and Sulli, Alberto and Cutolo, Maurizio},
  issn         = {0003-4967},
  journal      = {ANNALS OF THE RHEUMATIC DISEASES},
  keyword      = {CAPILLARY MICROSCOPY,MICROVASCULAR DAMAGE,CONNECTIVE-TISSUE DISEASE,LUPUS-ERYTHEMATOSUS,RAYNAUDS-PHENOMENON,SCLERODERMA,PATTERNS,AUTOANTIBODIES,CLASSIFICATION,DISORDERS},
  language     = {eng},
  number       = {6},
  pages        = {1092--1096},
  title        = {Reliability of the qualitative and semiquantitative nailfold videocapillaroscopy assessment in a systemic sclerosis cohort: a two-centre study},
  url          = {http://dx.doi.org/10.1136/ard.2009.115568},
  volume       = {69},
  year         = {2010},
}

Chicago
SMITH, VANESSA, Carmen Pizzorni, Filip De Keyser, Saskia Decuman, JENS VAN PRAET, Ellen Deschepper, Alberto Sulli, and Maurizio Cutolo. 2010. “Reliability of the Qualitative and Semiquantitative Nailfold Videocapillaroscopy Assessment in a Systemic Sclerosis Cohort: a Two-centre Study.” Annals of the Rheumatic Diseases 69 (6): 1092–1096.
APA
SMITH, V., Pizzorni, C., De Keyser, F., Decuman, S., VAN PRAET, J., Deschepper, E., Sulli, A., et al. (2010). Reliability of the qualitative and semiquantitative nailfold videocapillaroscopy assessment in a systemic sclerosis cohort: a two-centre study. ANNALS OF THE RHEUMATIC DISEASES, 69(6), 1092–1096.
Vancouver
1.
SMITH V, Pizzorni C, De Keyser F, Decuman S, VAN PRAET J, Deschepper E, et al. Reliability of the qualitative and semiquantitative nailfold videocapillaroscopy assessment in a systemic sclerosis cohort: a two-centre study. ANNALS OF THE RHEUMATIC DISEASES. 2010;69(6):1092–6.
MLA
SMITH, VANESSA, Carmen Pizzorni, Filip De Keyser, et al. “Reliability of the Qualitative and Semiquantitative Nailfold Videocapillaroscopy Assessment in a Systemic Sclerosis Cohort: a Two-centre Study.” ANNALS OF THE RHEUMATIC DISEASES 69.6 (2010): 1092–1096. Print.