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Interactions between gut inflammation and arthritis/spondylitis

Peggy Jacques (UGent) , Dirk Elewaut (UGent) and Herman Mielants (UGent)
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Abstract
Purpose of review: The spectrum of spondyloarthritis is characterized by the intriguing co-occurrence of gut and joint inflammation, although no obvious anatomical link exists. Recent findings: Data from animal models identify stromal cells as important players in pathogenesis, although signalling through TNFRI appeared to be sufficient for development of combined gut and joint inflammation. Interleukin-23 receptor was identified as a susceptibility locus for ankylosing spondylitis. Summary: Human genome studies combined with animal model research provide us with new evidence in the fascinating field of the gut-joint axis. However, how these newly identified genetic associations can influence the immunological environment remains to be elucidated.
Keywords
PLACEBO-CONTROLLED TRIAL, INTESTINAL EPITHELIAL-CELLS, UNFOLDED PROTEIN RESPONSE, SCAVENGER RECEPTOR CD163, HLA-B27 TRANSGENIC RATS, CROHNS-DISEASE, ANKYLOSING-SPONDYLITIS, BOWEL-DISEASE, T-CELLS, HLA-B27-TRANSGENIC RATS

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Citation

Please use this url to cite or link to this publication:

Chicago
Jacques, Peggy, Dirk Elewaut, and Herman Mielants. 2010. “Interactions Between Gut Inflammation and Arthritis/spondylitis.” Current Opinion in Rheumatology 22 (4): 368–374.
APA
Jacques, Peggy, Elewaut, D., & Mielants, H. (2010). Interactions between gut inflammation and arthritis/spondylitis. CURRENT OPINION IN RHEUMATOLOGY, 22(4), 368–374.
Vancouver
1.
Jacques P, Elewaut D, Mielants H. Interactions between gut inflammation and arthritis/spondylitis. CURRENT OPINION IN RHEUMATOLOGY. 2010;22(4):368–74.
MLA
Jacques, Peggy, Dirk Elewaut, and Herman Mielants. “Interactions Between Gut Inflammation and Arthritis/spondylitis.” CURRENT OPINION IN RHEUMATOLOGY 22.4 (2010): 368–374. Print.
@article{1095049,
  abstract     = {Purpose of review: The spectrum of spondyloarthritis is characterized by the intriguing co-occurrence of gut and joint inflammation, although no obvious anatomical link exists.
Recent findings: Data from animal models identify stromal cells as important players in pathogenesis, although signalling through TNFRI appeared to be sufficient for development of combined gut and joint inflammation. Interleukin-23 receptor was identified as a susceptibility locus for ankylosing spondylitis.
Summary: Human genome studies combined with animal model research provide us with new evidence in the fascinating field of the gut-joint axis. However, how these newly identified genetic associations can influence the immunological environment remains to be elucidated.},
  author       = {Jacques, Peggy and Elewaut, Dirk and Mielants, Herman},
  issn         = {1040-8711},
  journal      = {CURRENT OPINION IN RHEUMATOLOGY},
  keyword      = {PLACEBO-CONTROLLED TRIAL,INTESTINAL EPITHELIAL-CELLS,UNFOLDED PROTEIN RESPONSE,SCAVENGER RECEPTOR CD163,HLA-B27 TRANSGENIC RATS,CROHNS-DISEASE,ANKYLOSING-SPONDYLITIS,BOWEL-DISEASE,T-CELLS,HLA-B27-TRANSGENIC RATS},
  language     = {eng},
  number       = {4},
  pages        = {368--374},
  title        = {Interactions between gut inflammation and arthritis/spondylitis},
  url          = {http://dx.doi.org/10.1097/BOR.0b013e3283393807},
  volume       = {22},
  year         = {2010},
}

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