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Prognostic value and clinical significance of halo naevi regarding vitiligo

Nanja van Geel UGent, Sarah Vandenhaute UGent, Reinhart Speeckaert UGent, Lieve Brochez UGent, ILSE MOLLET UGent, LIESBETH DE COOMAN UGent and Jo Lambert UGent (2011) BRITISH JOURNAL OF DERMATOLOGY. 164(4). p.743-749
abstract
Background: Vitiligo and halo nevi can present together or separately. Whether it concerns different entities remains unclear. Objectives: To assess the clinical significance of halo nevi, both with respect to the future development of vitiligo, and to the clinical profile and course of vitiligo. Methods: In total 291 patients were included in this study, comparing patients with only halo nevi (group 1; n= 40), to patients with generalized vitiligo without halo nevi (group 2; n= 173) or generalized vitiligo with halo nevi (group 3; n= 78). Results: Patients with only halo nevi (group 1), reported significantly less associated auto-immune diseases (p=0.004), family history of vitiligo (p=0.013) and presence of Koebner phenomenon (p<0.001) compared to generalized vitiligo patients (group 2 + 3). Multiple halo nevi (≥3) were significantly more observed (p=0.002) in patients from group 1 compared to patients from group 3. In group 3, halo nevi were reported prior to the development of vitiligo in 61% (mean time interval of 33.7±5.17 months). No significant correlation could be observed between the presence of halo nevi and the extent, activity or subtype of vitiligo. However, halo nevi in vitiligo patients reduces significantly the risk for associated auto-immune diseases (p=0.02), and age of onset of vitiligo was significantly lower as compared to vitiligo patients without halo nevi (p<0.001). Conclusion: Our results support the hypothesis that halo nevi can represent a distinct condition. In a subset of patients, the occurrence of halo nevi may be an initiating factor in the pathogenesis of vitiligo.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
auto-immune diseases, melanocytes, halo naevi, vitiligo, GENOME-WIDE ASSOCIATION, GENERALIZED VITILIGO, SEGMENTAL VITILIGO, METAANALYSIS, ONSET
journal title
BRITISH JOURNAL OF DERMATOLOGY
Br. J. Dermatol.
volume
164
issue
4
pages
743 - 749
Web of Science type
Article
Web of Science id
000289150600009
JCR category
DERMATOLOGY
JCR impact factor
3.666 (2011)
JCR rank
7/58 (2011)
JCR quartile
1 (2011)
ISSN
0007-0963
DOI
10.1111/j.1365-2133.2010.10154.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1092516
handle
http://hdl.handle.net/1854/LU-1092516
date created
2010-12-23 15:25:10
date last changed
2012-04-26 10:32:34
@article{1092516,
  abstract     = {Background: Vitiligo and halo nevi can present together or separately. Whether it concerns different entities remains unclear.
Objectives: To assess the clinical significance of halo nevi, both with respect to the future development of vitiligo, and to the clinical profile and course of vitiligo.
Methods: In total 291 patients were included in this study, comparing patients with only halo nevi (group 1; n= 40), to patients with generalized vitiligo without halo nevi (group 2; n= 173) or generalized vitiligo with halo nevi (group 3; n= 78).
Results: Patients with only halo nevi (group 1), reported significantly less associated auto-immune diseases (p=0.004), family history of vitiligo (p=0.013) and presence of Koebner phenomenon (p{\textlangle}0.001) compared to generalized vitiligo patients (group 2 + 3). Multiple halo nevi (\ensuremath{\geq}3) were significantly more observed (p=0.002) in patients from group 1 compared to patients from group 3. In group 3, halo nevi were reported prior to the development of vitiligo in 61\% (mean time interval of 33.7{\textpm}5.17 months). No significant correlation could be observed between the presence of halo nevi and the extent, activity or subtype of vitiligo. However, halo nevi in vitiligo patients reduces significantly the risk for associated auto-immune diseases (p=0.02), and age of onset of vitiligo was significantly lower as compared to vitiligo patients without halo nevi (p{\textlangle}0.001).
Conclusion: Our results support the hypothesis that halo nevi can represent a distinct condition. In a subset of patients, the occurrence of halo nevi may be an initiating factor in the pathogenesis of vitiligo.},
  author       = {van Geel, Nanja and Vandenhaute, Sarah and Speeckaert, Reinhart and Brochez, Lieve and MOLLET, ILSE and DE COOMAN, LIESBETH and Lambert, Jo},
  issn         = {0007-0963},
  journal      = {BRITISH JOURNAL OF DERMATOLOGY},
  keyword      = {auto-immune diseases,melanocytes,halo naevi,vitiligo,GENOME-WIDE ASSOCIATION,GENERALIZED VITILIGO,SEGMENTAL VITILIGO,METAANALYSIS,ONSET},
  language     = {eng},
  number       = {4},
  pages        = {743--749},
  title        = {Prognostic value and clinical significance of halo naevi regarding vitiligo},
  url          = {http://dx.doi.org/10.1111/j.1365-2133.2010.10154.x},
  volume       = {164},
  year         = {2011},
}

Chicago
van Geel, Nanja, Sarah Vandenhaute, Reinhart Speeckaert, Lieve Brochez, ILSE MOLLET, LIESBETH DE COOMAN, and Jo Lambert. 2011. “Prognostic Value and Clinical Significance of Halo Naevi Regarding Vitiligo.” British Journal of Dermatology 164 (4): 743–749.
APA
van Geel, N., Vandenhaute, S., Speeckaert, R., Brochez, L., MOLLET, I., DE COOMAN, L., & Lambert, J. (2011). Prognostic value and clinical significance of halo naevi regarding vitiligo. BRITISH JOURNAL OF DERMATOLOGY, 164(4), 743–749.
Vancouver
1.
van Geel N, Vandenhaute S, Speeckaert R, Brochez L, MOLLET I, DE COOMAN L, et al. Prognostic value and clinical significance of halo naevi regarding vitiligo. BRITISH JOURNAL OF DERMATOLOGY. 2011;164(4):743–9.
MLA
van Geel, Nanja, Sarah Vandenhaute, Reinhart Speeckaert, et al. “Prognostic Value and Clinical Significance of Halo Naevi Regarding Vitiligo.” BRITISH JOURNAL OF DERMATOLOGY 164.4 (2011): 743–749. Print.