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Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus

Nanja van Geel UGent, Elien Wallaeys, BK Goh, Martine De Mil and Jo Lambert UGent (2010) BRITISH JOURNAL OF DERMATOLOGY. 163(6). p.1186-1193
abstract
Background Several surgical techniques are available for the treatment of stable leucoderma. The use of noncultured epidermal cellular grafting was introduced in 1992. Data on long-term follow-up regarding stability of the repigmented area, time to achieve the final repigmentation, colour matching, reaction to sun exposure and patient satisfaction with treatment have been reported only a few times previously. Objectives To evaluate the long-term results of the noncultured epidermal cellular grafting technique in patients with different types of leucoderma, including segmental vitiligo (n = 33), generalized vitiligo (n = 33), mixed vitiligo (n = 6), halo naevi (n = 11), piebaldism (n = 3) and naevus depigmentosus (n = 1). Methods Patients were evaluated by examination and questionnaire in a retrospective setting after transplantation by autologous noncultured cellular grafting. Percentage of repigmentation was evaluated in 82 patients using a digital imaging analysis system (mean follow-up 15 months). Long-term results were evaluated by 54 patients using a questionnaire up to 7·7 years after treatment (mean 4 years). Results More than 75% repigmentation was achieved in 71% of patients. Best results were obtained in segmental vitiligo, halo naevi and piebaldism, whereas results in generalized or mixed vitiligo were inferior. According to the patients, final repigmentation was achieved after a mean of 10 months post-treatment. In 80% some colour mismatch (hyperpigmentation and hypopigmentation) was reported between the treated area and the surrounding skin, although this was not disturbing for the majority. This colour mismatch was reported significantly less after sun exposure (P = 0·012). During follow-up 7% of patients, all with generalized vitiligo, observed some loss of the achieved repigmentation. Conclusions Autologous epidermal cellular grafting achieved a high percentage of repigmentation, which was maintained during follow-up in the majority of patients. Although it improved quality of life, a perfect colour match was seldom obtained.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
piebaldism, naevus depigmentosus, vitiligo, STABLE VITILIGO, REPIGMENTING VITILIGO, FOLLOW-UP, TRANSPLANTATION, MELANOCYTES, SUSPENSION, LESIONS, melanocyte transplantation, halo naevi, grafting
journal title
BRITISH JOURNAL OF DERMATOLOGY
Br. J. Dermatol.
volume
163
issue
6
pages
1186 - 1193
Web of Science type
Article
Web of Science id
000284368600008
JCR category
DERMATOLOGY
JCR impact factor
4.351 (2010)
JCR rank
3/54 (2010)
JCR quartile
1 (2010)
ISSN
0007-0963
DOI
10.1111/j.1365-2133.2010.10014.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1092241
handle
http://hdl.handle.net/1854/LU-1092241
date created
2010-12-23 13:40:48
date last changed
2016-12-19 15:45:03
@article{1092241,
  abstract     = {Background Several surgical techniques are available for the treatment of stable leucoderma. The use of noncultured epidermal cellular grafting was introduced in 1992. Data on long-term follow-up regarding stability of the repigmented area, time to achieve the final repigmentation, colour matching, reaction to sun exposure and patient satisfaction with treatment have been reported only a few times previously.
Objectives To evaluate the long-term results of the noncultured epidermal cellular grafting technique in patients with different types of leucoderma, including segmental vitiligo (n = 33), generalized vitiligo (n = 33), mixed vitiligo (n = 6), halo naevi (n = 11), piebaldism (n = 3) and naevus depigmentosus (n = 1).
Methods Patients were evaluated by examination and questionnaire in a retrospective setting after transplantation by autologous noncultured cellular grafting. Percentage of repigmentation was evaluated in 82 patients using a digital imaging analysis system (mean follow-up 15 months). Long-term results were evaluated by 54 patients using a questionnaire up to 7{\textperiodcentered}7 years after treatment (mean 4 years).
Results More than 75\% repigmentation was achieved in 71\% of patients. Best results were obtained in segmental vitiligo, halo naevi and piebaldism, whereas results in generalized or mixed vitiligo were inferior. According to the patients, final repigmentation was achieved after a mean of 10 months post-treatment. In 80\% some colour mismatch (hyperpigmentation and hypopigmentation) was reported between the treated area and the surrounding skin, although this was not disturbing for the majority. This colour mismatch was reported significantly less after sun exposure (P = 0{\textperiodcentered}012). During follow-up 7\% of patients, all with generalized vitiligo, observed some loss of the achieved repigmentation.
Conclusions Autologous epidermal cellular grafting achieved a high percentage of repigmentation, which was maintained during follow-up in the majority of patients. Although it improved quality of life, a perfect colour match was seldom obtained.},
  author       = {van Geel, Nanja and Wallaeys, Elien and Goh, BK and De Mil, Martine and Lambert, Jo},
  issn         = {0007-0963},
  journal      = {BRITISH JOURNAL OF DERMATOLOGY},
  keyword      = {piebaldism,naevus depigmentosus,vitiligo,STABLE VITILIGO,REPIGMENTING VITILIGO,FOLLOW-UP,TRANSPLANTATION,MELANOCYTES,SUSPENSION,LESIONS,melanocyte transplantation,halo naevi,grafting},
  language     = {eng},
  number       = {6},
  pages        = {1186--1193},
  title        = {Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus},
  url          = {http://dx.doi.org/10.1111/j.1365-2133.2010.10014.x},
  volume       = {163},
  year         = {2010},
}

Chicago
van Geel, Nanja, Elien Wallaeys, BK Goh, MARTINE DE MIL, and Jo Lambert. 2010. “Long-term Results of Noncultured Epidermal Cellular Grafting in Vitiligo, Halo Naevi, Piebaldism and Naevus Depigmentosus.” British Journal of Dermatology 163 (6): 1186–1193.
APA
van Geel, N., Wallaeys, E., Goh, B., DE MIL, M., & Lambert, J. (2010). Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus. BRITISH JOURNAL OF DERMATOLOGY, 163(6), 1186–1193.
Vancouver
1.
van Geel N, Wallaeys E, Goh B, DE MIL M, Lambert J. Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus. BRITISH JOURNAL OF DERMATOLOGY. 2010;163(6):1186–93.
MLA
van Geel, Nanja, Elien Wallaeys, BK Goh, et al. “Long-term Results of Noncultured Epidermal Cellular Grafting in Vitiligo, Halo Naevi, Piebaldism and Naevus Depigmentosus.” BRITISH JOURNAL OF DERMATOLOGY 163.6 (2010): 1186–1193. Print.