Advanced search
1 file | 187.22 KB

Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP

Author
Organization
Abstract
We previously carried out a genome-wide association study of generalized vitiligo (GV) in non-Hispanic whites, identifying 13 confirmed susceptibility loci. In this study, we re-analyzed the genome-wide data set (comprising 1,392 cases and 2,629 controls) to specifically test association of all 33 GV candidate genes that have previously been suggested for GV, followed by meta-analysis incorporating both current and previously published data. We detected association of three of the candidate genes tested: TSLP (rs764916, P=3.0E-04, odds ratio (OR)=1.60; meta-P for rs3806933=3.1E-03), XBP1 (rs6005863, P=3.6E-04, OR=1.17; meta-P for rs2269577=9.5E-09), and FOXP3 (rs11798415, P=5.8E-04, OR=1.19). Association of GV with CTLA4 (rs12992492, P=5.9E-05, OR=1.20; meta-P for rs231775=1.0E-04) seems to be secondary to epidemiological association with other concomitant autoimmune diseases. Within the major histocompatibility complex (MHC), at 6p21.33, association with TAP1-PSMB8 (rs3819721, P=5.2E-06) seems to derive from linkage disequilibrium with major primary signals in the MHC class I and class II regions.
Keywords
CHINESE POPULATIONS, NONSEGMENTAL VITILIGO, GUJARAT POPULATION, CATALASE GENE, FUNCTIONAL POLYMORPHISMS, SUSCEPTIBILITY LOCI, AUTOIMMUNE-DISEASES, KOREAN POPULATION, ANGIOTENSIN-CONVERTING ENZYME, NON-SEGMENTAL VITILIGO

Downloads

  • (...)
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 187.22 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Birlea, Stanca A, Ying Jin, Dorothy C Bennett, Deborah M Herbstman, Margaret R Wallace, Wayne T McCormack, E Helen Kemp, et al. 2011. “Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP.” Journal of Investigative Dermatology 131 (2): 371–381.
APA
Birlea, S. A., Jin, Y., Bennett, D. C., Herbstman, D. M., Wallace, M. R., McCormack, W. T., Kemp, E. H., et al. (2011). Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(2), 371–381.
Vancouver
1.
Birlea SA, Jin Y, Bennett DC, Herbstman DM, Wallace MR, McCormack WT, et al. Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(2):371–81.
MLA
Birlea, Stanca A, Ying Jin, Dorothy C Bennett, et al. “Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP.” JOURNAL OF INVESTIGATIVE DERMATOLOGY 131.2 (2011): 371–381. Print.
@article{1092190,
  abstract     = {We previously carried out a genome-wide association study of generalized vitiligo (GV) in non-Hispanic whites, identifying 13 confirmed susceptibility loci. In this study, we re-analyzed the genome-wide data set (comprising 1,392 cases and 2,629 controls) to specifically test association of all 33 GV candidate genes that have previously been suggested for GV, followed by meta-analysis incorporating both current and previously published data. We detected association of three of the candidate genes tested: TSLP (rs764916, P=3.0E-04, odds ratio (OR)=1.60; meta-P for rs3806933=3.1E-03), XBP1 (rs6005863, P=3.6E-04, OR=1.17; meta-P for rs2269577=9.5E-09), and FOXP3 (rs11798415, P=5.8E-04, OR=1.19). Association of GV with CTLA4 (rs12992492, P=5.9E-05, OR=1.20; meta-P for rs231775=1.0E-04) seems to be secondary to epidemiological association with other concomitant autoimmune diseases. Within the major histocompatibility complex (MHC), at 6p21.33, association with TAP1-PSMB8 (rs3819721, P=5.2E-06) seems to derive from linkage disequilibrium with major primary signals in the MHC class I and class II regions.},
  author       = {Birlea, Stanca A and Jin, Ying and Bennett, Dorothy C and Herbstman, Deborah M and Wallace, Margaret R and McCormack, Wayne T and Kemp, E Helen and Gawkrodger, David J and Weetman, Anthony P and Picardo, Mauro and Leone, Giovanni  and Ta{\"i}eb, Alain and Jouary, Thomas and Ezzedine, Khaled and van Geel, Nanja and Lambert, Jo and Overbeck, Andreas and Fain, Pamela R and Spritz, Richard A},
  issn         = {0022-202X},
  journal      = {JOURNAL OF INVESTIGATIVE DERMATOLOGY},
  keyword      = {CHINESE POPULATIONS,NONSEGMENTAL VITILIGO,GUJARAT POPULATION,CATALASE GENE,FUNCTIONAL POLYMORPHISMS,SUSCEPTIBILITY LOCI,AUTOIMMUNE-DISEASES,KOREAN POPULATION,ANGIOTENSIN-CONVERTING ENZYME,NON-SEGMENTAL VITILIGO},
  language     = {eng},
  number       = {2},
  pages        = {371--381},
  title        = {Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP},
  url          = {http://dx.doi.org/10.1038/jid.2010.337},
  volume       = {131},
  year         = {2011},
}

Altmetric
View in Altmetric
Web of Science
Times cited: