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Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP

Stanca A Birlea, Ying Jin, Dorothy C Bennett, Deborah M Herbstman, Margaret R Wallace, Wayne T McCormack, E Helen Kemp, David J Gawkrodger, Anthony P Weetman, Mauro Picardo, et al. (2011) JOURNAL OF INVESTIGATIVE DERMATOLOGY. 131(2). p.371-381
abstract
We previously carried out a genome-wide association study of generalized vitiligo (GV) in non-Hispanic whites, identifying 13 confirmed susceptibility loci. In this study, we re-analyzed the genome-wide data set (comprising 1,392 cases and 2,629 controls) to specifically test association of all 33 GV candidate genes that have previously been suggested for GV, followed by meta-analysis incorporating both current and previously published data. We detected association of three of the candidate genes tested: TSLP (rs764916, P=3.0E-04, odds ratio (OR)=1.60; meta-P for rs3806933=3.1E-03), XBP1 (rs6005863, P=3.6E-04, OR=1.17; meta-P for rs2269577=9.5E-09), and FOXP3 (rs11798415, P=5.8E-04, OR=1.19). Association of GV with CTLA4 (rs12992492, P=5.9E-05, OR=1.20; meta-P for rs231775=1.0E-04) seems to be secondary to epidemiological association with other concomitant autoimmune diseases. Within the major histocompatibility complex (MHC), at 6p21.33, association with TAP1-PSMB8 (rs3819721, P=5.2E-06) seems to derive from linkage disequilibrium with major primary signals in the MHC class I and class II regions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CHINESE POPULATIONS, NONSEGMENTAL VITILIGO, GUJARAT POPULATION, CATALASE GENE, FUNCTIONAL POLYMORPHISMS, SUSCEPTIBILITY LOCI, AUTOIMMUNE-DISEASES, KOREAN POPULATION, ANGIOTENSIN-CONVERTING ENZYME, NON-SEGMENTAL VITILIGO
journal title
JOURNAL OF INVESTIGATIVE DERMATOLOGY
J. Invest. Dermatol.
volume
131
issue
2
pages
371 - 381
Web of Science type
Article
Web of Science id
000286177500017
JCR category
DERMATOLOGY
JCR impact factor
6.314 (2011)
JCR rank
1/58 (2011)
JCR quartile
1 (2011)
ISSN
0022-202X
DOI
10.1038/jid.2010.337
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1092190
handle
http://hdl.handle.net/1854/LU-1092190
date created
2010-12-23 12:43:26
date last changed
2017-05-09 13:56:03
@article{1092190,
  abstract     = {We previously carried out a genome-wide association study of generalized vitiligo (GV) in non-Hispanic whites, identifying 13 confirmed susceptibility loci. In this study, we re-analyzed the genome-wide data set (comprising 1,392 cases and 2,629 controls) to specifically test association of all 33 GV candidate genes that have previously been suggested for GV, followed by meta-analysis incorporating both current and previously published data. We detected association of three of the candidate genes tested: TSLP (rs764916, P=3.0E-04, odds ratio (OR)=1.60; meta-P for rs3806933=3.1E-03), XBP1 (rs6005863, P=3.6E-04, OR=1.17; meta-P for rs2269577=9.5E-09), and FOXP3 (rs11798415, P=5.8E-04, OR=1.19). Association of GV with CTLA4 (rs12992492, P=5.9E-05, OR=1.20; meta-P for rs231775=1.0E-04) seems to be secondary to epidemiological association with other concomitant autoimmune diseases. Within the major histocompatibility complex (MHC), at 6p21.33, association with TAP1-PSMB8 (rs3819721, P=5.2E-06) seems to derive from linkage disequilibrium with major primary signals in the MHC class I and class II regions.},
  author       = {Birlea, Stanca A and Jin, Ying and Bennett, Dorothy C and Herbstman, Deborah M and Wallace, Margaret R and McCormack, Wayne T and Kemp, E Helen and Gawkrodger, David J and Weetman, Anthony P and Picardo, Mauro and Leone, Giovanni  and Ta{\"i}eb, Alain and Jouary, Thomas and Ezzedine, Khaled and van Geel, Nanja and Lambert, Jo and Overbeck, Andreas and Fain, Pamela R and Spritz, Richard A},
  issn         = {0022-202X},
  journal      = {JOURNAL OF INVESTIGATIVE DERMATOLOGY},
  keyword      = {CHINESE POPULATIONS,NONSEGMENTAL VITILIGO,GUJARAT POPULATION,CATALASE GENE,FUNCTIONAL POLYMORPHISMS,SUSCEPTIBILITY LOCI,AUTOIMMUNE-DISEASES,KOREAN POPULATION,ANGIOTENSIN-CONVERTING ENZYME,NON-SEGMENTAL VITILIGO},
  language     = {eng},
  number       = {2},
  pages        = {371--381},
  title        = {Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP},
  url          = {http://dx.doi.org/10.1038/jid.2010.337},
  volume       = {131},
  year         = {2011},
}

Chicago
Birlea, Stanca A, Ying Jin, Dorothy C Bennett, Deborah M Herbstman, Margaret R Wallace, Wayne T McCormack, E Helen Kemp, et al. 2011. “Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP.” Journal of Investigative Dermatology 131 (2): 371–381.
APA
Birlea, S. A., Jin, Y., Bennett, D. C., Herbstman, D. M., Wallace, M. R., McCormack, W. T., Kemp, E. H., et al. (2011). Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(2), 371–381.
Vancouver
1.
Birlea SA, Jin Y, Bennett DC, Herbstman DM, Wallace MR, McCormack WT, et al. Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(2):371–81.
MLA
Birlea, Stanca A, Ying Jin, Dorothy C Bennett, et al. “Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP.” JOURNAL OF INVESTIGATIVE DERMATOLOGY 131.2 (2011): 371–381. Print.