Ghent University Academic Bibliography

Advanced

Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy

Reinhart Speeckaert UGent, Nanja van Geel UGent, Karim Vermaelen UGent, Jo Lambert UGent, Mireille Van Gele UGent, MARIJN SPEECKAERT UGent and Lieve Brochez UGent (2011) PIGMENT CELL & MELANOMA RESEARCH. 24(2). p.334-344
abstract
Spontaneous regression of benign and malignant melanocytic lesions can be a visible sign of immunosurveillance. In this review, we discuss different immune reactions against melanocytic lesions: halo nevus, Meyerson's nevus, regression in melanoma and melanoma-associated depigmentation. These entities present with particular clinical aspects, histology and evolution. In all entities, a melanocyte-specific T-cell reaction has been assumed but a different degree of melanocyte destruction is present. A focus on the immune responses in melanocytic lesions reveals several aspects of an adequate skin immunity and may help to identify the key points in the immune destruction of melanocytes. These insights can add to the knowledge of how to optimize immunotherapeutic strategies in melanoma.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
melanoma, immunosurveillance, melanocyte, halo nevus, Meyerson's nevus, melanoma-associated depigmentation, regression, PLASMACYTOID DENDRITIC CELLS, REGULATORY T-CELLS, HALO-NEVUS, METASTATIC MELANOMA, TUMOR-REGRESSION, MEYERSONS NEVUS, IMMUNOSUPPRESSIVE THERAPY, CUTANEOUS MELANOMA, PROGNOSTIC-FACTOR, LANGERHANS CELLS
journal title
PIGMENT CELL & MELANOMA RESEARCH
Pigment Cell Melanoma Res.
volume
24
issue
2
pages
334 - 344
Web of Science type
Review
Web of Science id
000288219200012
JCR category
DERMATOLOGY
JCR impact factor
5.059 (2011)
JCR rank
2/58 (2011)
JCR quartile
1 (2011)
ISSN
1755-1471
DOI
10.1111/j.1755-148x.2010.00799.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1092053
handle
http://hdl.handle.net/1854/LU-1092053
date created
2010-12-23 11:44:37
date last changed
2012-04-26 10:24:13
@article{1092053,
  abstract     = {Spontaneous regression of benign and malignant melanocytic lesions can be a visible sign of immunosurveillance. In this review, we discuss different immune reactions against melanocytic lesions: halo nevus, Meyerson's nevus, regression in melanoma and melanoma-associated depigmentation. These entities present with particular clinical aspects, histology and evolution. In all entities, a melanocyte-specific T-cell reaction has been assumed but a different degree of melanocyte destruction is present. A focus on the immune responses in melanocytic lesions reveals several aspects of an adequate skin immunity and may help to identify the key points in the immune destruction of melanocytes. These insights can add to the knowledge of how to optimize immunotherapeutic strategies in melanoma.},
  author       = {Speeckaert, Reinhart and van Geel, Nanja and Vermaelen, Karim and Lambert, Jo and Van Gele, Mireille and SPEECKAERT, MARIJN and Brochez, Lieve},
  issn         = {1755-1471},
  journal      = {PIGMENT CELL \& MELANOMA RESEARCH},
  keyword      = {melanoma,immunosurveillance,melanocyte,halo nevus,Meyerson's nevus,melanoma-associated depigmentation,regression,PLASMACYTOID DENDRITIC CELLS,REGULATORY T-CELLS,HALO-NEVUS,METASTATIC MELANOMA,TUMOR-REGRESSION,MEYERSONS NEVUS,IMMUNOSUPPRESSIVE THERAPY,CUTANEOUS MELANOMA,PROGNOSTIC-FACTOR,LANGERHANS CELLS},
  language     = {eng},
  number       = {2},
  pages        = {334--344},
  title        = {Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy},
  url          = {http://dx.doi.org/10.1111/j.1755-148x.2010.00799.x},
  volume       = {24},
  year         = {2011},
}

Chicago
Speeckaert, Reinhart, Nanja van Geel, Karim Vermaelen, Jo Lambert, Mireille Van Gele, MARIJN SPEECKAERT, and Lieve Brochez. 2011. “Immune Reactions in Benign and Malignant Melanocytic Lesions: Lessons for Immunotherapy.” Pigment Cell & Melanoma Research 24 (2): 334–344.
APA
Speeckaert, R., van Geel, N., Vermaelen, K., Lambert, J., Van Gele, M., SPEECKAERT, M., & Brochez, L. (2011). Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy. PIGMENT CELL & MELANOMA RESEARCH, 24(2), 334–344.
Vancouver
1.
Speeckaert R, van Geel N, Vermaelen K, Lambert J, Van Gele M, SPEECKAERT M, et al. Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy. PIGMENT CELL & MELANOMA RESEARCH. 2011;24(2):334–44.
MLA
Speeckaert, Reinhart, Nanja van Geel, Karim Vermaelen, et al. “Immune Reactions in Benign and Malignant Melanocytic Lesions: Lessons for Immunotherapy.” PIGMENT CELL & MELANOMA RESEARCH 24.2 (2011): 334–344. Print.