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Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses

(2010) ANIMAL GENETICS. 41(suppl. 2). p.2-7
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Abstract
The recent completion of the horse genome and commercial availability of an equine SNP genotyping array has facilitated the mapping of disease genes. We report putative localization of the gene responsible for dwarfism, a trait in Friesian horses that is thought to have a recessive mode of inheritance, to a 2- MB region of chromosome 14 using just 10 affected animals and 10 controls. We successfully genotyped 34 429 SNPs that were tested for association with dwarfism using chi-square tests. The most significant SNP in our study, BIEC2-239376 (P-2df = 4.54 x 10-5, P-rec = 7.74 x 10-6), is located close to a gene implicated in human dwarfism. Fine-mapping and resequencing analyses did not aid in further localization of the causative variant, and replication of our findings in independent sample sets will be necessary to confirm these results.
Keywords
Friesian, gene, dwarfism, GWAS, TOOL, SEQUENCE, DEFECTS, DISEASE, FOALS, PITUITARY DWARFISM, GROWTH-PLATE, horse, SNP association, GERMAN-SHEPHERD DOGS

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MLA
Orr, N, Willem Back, J Gu, et al. “Genome-wide SNP Association-based Localization of a Dwarfism Gene in Friesian Dwarf Horses.” ANIMAL GENETICS 41.suppl. 2 (2010): 2–7. Print.
APA
Orr, N., Back, W., Gu, J., Leegwater, P., Govindarajan, P., Conroy, J., Ducro, B., et al. (2010). Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses. ANIMAL GENETICS, 41(suppl. 2), 2–7.
Chicago author-date
Orr, N, Willem Back, J Gu, P Leegwater, P Govindarajan, J Conroy, B Ducro, et al. 2010. “Genome-wide SNP Association-based Localization of a Dwarfism Gene in Friesian Dwarf Horses.” Animal Genetics 41 (suppl. 2): 2–7.
Chicago author-date (all authors)
Orr, N, Willem Back, J Gu, P Leegwater, P Govindarajan, J Conroy, B Ducro, JAM Van Arendonk, DE MacHugh, S Ennis, EW Hill, and PAJ Brama. 2010. “Genome-wide SNP Association-based Localization of a Dwarfism Gene in Friesian Dwarf Horses.” Animal Genetics 41 (suppl. 2): 2–7.
Vancouver
1.
Orr N, Back W, Gu J, Leegwater P, Govindarajan P, Conroy J, et al. Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses. ANIMAL GENETICS. 2010;41(suppl. 2):2–7.
IEEE
[1]
N. Orr et al., “Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses,” ANIMAL GENETICS, vol. 41, no. suppl. 2, pp. 2–7, 2010.
@article{1091827,
  abstract     = {The recent completion of the horse genome and commercial availability of an equine SNP genotyping array has facilitated the mapping of disease genes. We report putative localization of the gene responsible for dwarfism, a trait in Friesian horses that is thought to have a recessive mode of inheritance, to a 2- MB region of chromosome 14 using just 10 affected animals and 10 controls. We successfully genotyped 34 429 SNPs that were tested for association with dwarfism using chi-square tests. The most significant SNP in our study, BIEC2-239376 (P-2df = 4.54 x 10-5, P-rec = 7.74 x 10-6), is located close to a gene implicated in human dwarfism. Fine-mapping and resequencing analyses did not aid in further localization of the causative variant, and replication of our findings in independent sample sets will be necessary to confirm these results.},
  author       = {Orr, N and Back, Willem and Gu, J and Leegwater, P and Govindarajan, P and Conroy, J and Ducro, B and Van Arendonk, JAM and MacHugh, DE and Ennis, S and Hill, EW and Brama, PAJ},
  issn         = {0268-9146},
  journal      = {ANIMAL GENETICS},
  keywords     = {Friesian,gene,dwarfism,GWAS,TOOL,SEQUENCE,DEFECTS,DISEASE,FOALS,PITUITARY DWARFISM,GROWTH-PLATE,horse,SNP association,GERMAN-SHEPHERD DOGS},
  language     = {eng},
  number       = {suppl. 2},
  pages        = {2--7},
  title        = {Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses},
  url          = {http://dx.doi.org/10.1111/j.1365-2052.2010.02091.x},
  volume       = {41},
  year         = {2010},
}

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