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Prevention of Candida albicans biofilm formation by covalently bound dimethylaminoethylmethacrylate and polyethylenimine

Kristof De Prijck (UGent) , Nele De Smet (UGent) , Tom Coenye (UGent) , Etienne Schacht (UGent) and Hans Nelis (UGent)
(2010) MYCOPATHOLOGIA. 170(4). p.213-221
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Abstract
Candida albicans biofilms are a major cause of voice prosthesis deterioration in laryngectomized patients. The aim of this study was to produce a surface capable of inhibiting C. albicans biofilm formation. Dimethylaminoethylmethacrylate (DMAEMA) and polyethylenimine (PEI) moieties were covalently bound to the surface of polydimethylsiloxane (PDMS) or polymethylmethacrylate (PMMA) and subsequently quaternized. Physicochemical characterization of the grafted surfaces was carried out and their effect on C. albicans cell numbers was assessed using a modified Robbins device to grow the biofilms. Covalently bound quaternized polyDMAEMA (polyDMAEMAq) and PEI (PEIq) inhibited biofilm growth, with reductions up to 92%. Our approach may show promise for future application in medical devices such as catheters and prostheses.
Keywords
IN-VITRO, ALKYLATED POLYETHYLENIMINE, Grafting, SURFACE MODIFICATION, Dimethylaminoethylmethacrylate, Polyethylenimine, Biofilm, Candida albicans, Modified Robbins Device, TRACHEOESOPHAGEAL VOICE PROSTHESES, BIOLOGICALLY-ACTIVE POLYMERS, PHOSPHONIUM GROUPS, AMMONIUM SILANE COATINGS, ANTIMICROBIAL ACTIVITY, QUATERNARY AMMONIUM, SILICONE-RUBBER

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Chicago
De Prijck, Kristof, Nele De Smet, Tom Coenye, Etienne Schacht, and Hans Nelis. 2010. “Prevention of Candida Albicans Biofilm Formation by Covalently Bound Dimethylaminoethylmethacrylate and Polyethylenimine.” Mycopathologia 170 (4): 213–221.
APA
De Prijck, K., De Smet, N., Coenye, T., Schacht, E., & Nelis, H. (2010). Prevention of Candida albicans biofilm formation by covalently bound dimethylaminoethylmethacrylate and polyethylenimine. MYCOPATHOLOGIA, 170(4), 213–221.
Vancouver
1.
De Prijck K, De Smet N, Coenye T, Schacht E, Nelis H. Prevention of Candida albicans biofilm formation by covalently bound dimethylaminoethylmethacrylate and polyethylenimine. MYCOPATHOLOGIA. 2010;170(4):213–21.
MLA
De Prijck, Kristof, Nele De Smet, Tom Coenye, et al. “Prevention of Candida Albicans Biofilm Formation by Covalently Bound Dimethylaminoethylmethacrylate and Polyethylenimine.” MYCOPATHOLOGIA 170.4 (2010): 213–221. Print.
@article{1086083,
  abstract     = {Candida albicans biofilms are a major cause of voice prosthesis deterioration in laryngectomized patients. The aim of this study was to produce a surface capable of inhibiting C. albicans biofilm formation. Dimethylaminoethylmethacrylate (DMAEMA) and polyethylenimine (PEI) moieties were covalently bound to the surface of polydimethylsiloxane (PDMS) or polymethylmethacrylate (PMMA) and subsequently quaternized. Physicochemical characterization of the grafted surfaces was carried out and their effect on C. albicans cell numbers was assessed using a modified Robbins device to grow the biofilms. Covalently bound quaternized polyDMAEMA (polyDMAEMAq) and PEI (PEIq) inhibited biofilm growth, with reductions up to 92%. Our approach may show promise for future application in medical devices such as catheters and prostheses.},
  author       = {De Prijck, Kristof and De Smet, Nele and Coenye, Tom and Schacht, Etienne and Nelis, Hans},
  issn         = {0301-486X},
  journal      = {MYCOPATHOLOGIA},
  keywords     = {IN-VITRO,ALKYLATED POLYETHYLENIMINE,Grafting,SURFACE MODIFICATION,Dimethylaminoethylmethacrylate,Polyethylenimine,Biofilm,Candida albicans,Modified Robbins Device,TRACHEOESOPHAGEAL VOICE PROSTHESES,BIOLOGICALLY-ACTIVE POLYMERS,PHOSPHONIUM GROUPS,AMMONIUM SILANE COATINGS,ANTIMICROBIAL ACTIVITY,QUATERNARY AMMONIUM,SILICONE-RUBBER},
  language     = {eng},
  number       = {4},
  pages        = {213--221},
  title        = {Prevention of Candida albicans biofilm formation by covalently bound dimethylaminoethylmethacrylate and polyethylenimine},
  url          = {http://dx.doi.org/10.1007/s11046-010-9316-3},
  volume       = {170},
  year         = {2010},
}

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