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The metabolisation of different iodinated peptide species

Bart De Spiegeleer UGent, Sylvia Van Dorpe and Ewald Pauwels UGent (2010) Peptides 2010 : tales of peptides : proceedings of the thirty-first European Peptide Symposium. p.502-503
abstract
Radioiodinated I-123, I-125 or I-131 labelled peptides are often used in biomedical research and diagnostic-therapeutic clinical practice. Moreover, iodine is a bio-essential element with specific physiology and biochemistry. Two enzymatic systems are known to handle iodinated organics: iodotyrosinedeiodinase (IYD) and iodothyroninedeiodinase (ID). However, at this moment, only iodinated amino acids and the thyroid hormones have been studied, but no systematic study on the metabolic fate of iodinated peptides is available. Using HPLC-DAD/MS/MS and HALO-columns, we have characterised different iodinated mouse obestatin peptides towards their in vitro metabolisation. The degradation kinetics and metabolites of the different iodinated obestatin-peptides arising from both enzymatic proteolysis and dehalogenation is studied.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
in
Peptides 2010 : tales of peptides : proceedings of the thirty-first European Peptide Symposium
editor
Michal Lebl, Morten Meldal, Knud J Jensen and Thomas Høeg-Jensen
pages
502 - 503
publisher
European Peptide Society
conference name
31st European Peptide Symposium
conference location
Copenhagen, Denmark
conference start
2010-09-05
conference end
2010-09-09
ISBN
0-9715560-5-9
project
HPC-UGent: the central High Performance Computing infrastructure of Ghent University
language
English
UGent publication?
yes
classification
C1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1083649
handle
http://hdl.handle.net/1854/LU-1083649
date created
2010-12-06 15:03:01
date last changed
2016-12-19 15:34:54
@inproceedings{1083649,
  abstract     = {Radioiodinated I-123, I-125 or I-131 labelled peptides are often used in biomedical research and diagnostic-therapeutic clinical practice. Moreover, iodine is a bio-essential element with specific physiology and biochemistry. Two enzymatic systems are known to handle iodinated organics: iodotyrosinedeiodinase (IYD) and iodothyroninedeiodinase (ID). However, at this moment, only iodinated amino acids and the thyroid hormones have been studied, but no systematic study on the metabolic fate of iodinated peptides is available.
Using HPLC-DAD/MS/MS and HALO-columns, we have characterised different iodinated mouse obestatin peptides towards their in vitro metabolisation. The degradation kinetics and metabolites of the different iodinated obestatin-peptides arising from both enzymatic proteolysis and dehalogenation is studied.},
  author       = {De Spiegeleer, Bart and Van Dorpe, Sylvia and Pauwels, Ewald},
  booktitle    = {Peptides 2010 : tales of peptides : proceedings of the thirty-first European Peptide Symposium},
  editor       = {Lebl, Michal and Meldal, Morten and Jensen, Knud J and H{\o}eg-Jensen, Thomas},
  isbn         = {0-9715560-5-9},
  language     = {eng},
  location     = {Copenhagen, Denmark},
  pages        = {502--503},
  publisher    = {European Peptide Society},
  title        = {The metabolisation of different iodinated peptide species},
  year         = {2010},
}

Chicago
De Spiegeleer, Bart, Sylvia Van Dorpe, and Ewald Pauwels. 2010. “The Metabolisation of Different Iodinated Peptide Species.” In Peptides 2010 : Tales of Peptides : Proceedings of the Thirty-first European Peptide Symposium, ed. Michal Lebl, Morten Meldal, Knud J Jensen, and Thomas Høeg-Jensen, 502–503. European Peptide Society.
APA
De Spiegeleer, B., Van Dorpe, S., & Pauwels, E. (2010). The metabolisation of different iodinated peptide species. In M. Lebl, M. Meldal, K. J. Jensen, & T. Høeg-Jensen (Eds.), Peptides 2010 : tales of peptides : proceedings of the thirty-first European Peptide Symposium (pp. 502–503). Presented at the 31st European Peptide Symposium, European Peptide Society.
Vancouver
1.
De Spiegeleer B, Van Dorpe S, Pauwels E. The metabolisation of different iodinated peptide species. In: Lebl M, Meldal M, Jensen KJ, Høeg-Jensen T, editors. Peptides 2010 : tales of peptides : proceedings of the thirty-first European Peptide Symposium. European Peptide Society; 2010. p. 502–3.
MLA
De Spiegeleer, Bart, Sylvia Van Dorpe, and Ewald Pauwels. “The Metabolisation of Different Iodinated Peptide Species.” Peptides 2010 : Tales of Peptides : Proceedings of the Thirty-first European Peptide Symposium. Ed. Michal Lebl et al. European Peptide Society, 2010. 502–503. Print.