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Serum N-glycan profile shift during human ageing

Valerie Vanhooren UGent, Sylviane Dewaele UGent, Claude Libert UGent, Sebastiaan Engelborghs, Peter Paul De Deyn, Olivier Toussaint, Florence Debacq-Chainiaux, Michel Poulain, Youri Glupczynski and Claudio Franceschi, et al. (2010) EXPERIMENTAL GERONTOLOGY. 45(10). p.738-743
abstract
Biomarkers indicating biological age are of significant interest for prevention, diagnosis and monitoring (and the treatment) of age-related diseases. We previously reported an alteration of serum N-glycan profile in old humans using "DNA Sequencer Adapted-Fluorophore Assisted Carbohydrate Electrophoresis" (DSA-FACE). To validate the shift in serum N-glycan profile during ageing, we studied serum N-glycan profiles in different age groups of healthy volunteers, patients with dementia, and patients with Cockayne syndrome, a genetic DNA repair disorder involving neurodegeneration and premature ageing. We found that the log of the ratio of two glycans (NGA2F and NA2F), named GlycoAgeTest, remained steady up to the age of 40years and thereafter gradually increased to reach its highest level in nonagenarians. Patients with dementia or Cockayne syndrome had a higher GlycoAgeTest level than age-matched healthy individuals. We thus demonstrate that the value of GlycoAgeTest is better than chronological age for estimating the physiological age of a human individual, and that it could be used as an ageing biomarker for healthy humans. Our data indicate that the GlycoAgeTest could be used as a non-invasive surrogate marker for general health, for forecasting disease progression during ageing, and for monitoring the efficacy of anti-ageing food compounds.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
N-glycan profile, NUCLEOTIDE EXCISION-REPAIR, Age-related disease, Ageing, Biomarker, BODY-MASS INDEX, COCKAYNE-SYNDROME, HEPATOCELLULAR-CARCINOMA, GENETIC POLYMORPHISMS, GLYCOMIC CHANGES, DISEASE, CIRRHOSIS, DEMENTIA, GLYCOSYLATION
journal title
EXPERIMENTAL GERONTOLOGY
Exp. Gerontol.
volume
45
issue
10
pages
738 - 743
Web of Science type
Article
Web of Science id
000283891500003
JCR category
GERIATRICS & GERONTOLOGY
JCR impact factor
3.804 (2010)
JCR rank
10/42 (2010)
JCR quartile
1 (2010)
ISSN
0531-5565
DOI
10.1016/j.exger.2010.08.009
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1082098
handle
http://hdl.handle.net/1854/LU-1082098
date created
2010-12-03 15:13:52
date last changed
2012-06-26 14:32:12
@article{1082098,
  abstract     = {Biomarkers indicating biological age are of significant interest for prevention, diagnosis and monitoring (and the treatment) of age-related diseases. We previously reported an alteration of serum N-glycan profile in old humans using {\textacutedbl}DNA Sequencer Adapted-Fluorophore Assisted Carbohydrate Electrophoresis{\textacutedbl} (DSA-FACE). To validate the shift in serum N-glycan profile during ageing, we studied serum N-glycan profiles in different age groups of healthy volunteers, patients with dementia, and patients with Cockayne syndrome, a genetic DNA repair disorder involving neurodegeneration and premature ageing. We found that the log of the ratio of two glycans (NGA2F and NA2F), named GlycoAgeTest, remained steady up to the age of 40years and thereafter gradually increased to reach its highest level in nonagenarians. Patients with dementia or Cockayne syndrome had a higher GlycoAgeTest level than age-matched healthy individuals. We thus demonstrate that the value of GlycoAgeTest is better than chronological age for estimating the physiological age of a human individual, and that it could be used as an ageing biomarker for healthy humans. Our data indicate that the GlycoAgeTest could be used as a non-invasive surrogate marker for general health, for forecasting disease progression during ageing, and for monitoring the efficacy of anti-ageing food compounds.},
  author       = {Vanhooren, Valerie and Dewaele, Sylviane and Libert, Claude and Engelborghs, Sebastiaan and De Deyn, Peter Paul and Toussaint, Olivier and Debacq-Chainiaux, Florence and Poulain, Michel and Glupczynski, Youri and Franceschi, Claudio and Jaspers, Koos and van der Pluijm, Ingrid and Hoeijmakers, Jan and Chen, Cuiying},
  issn         = {0531-5565},
  journal      = {EXPERIMENTAL GERONTOLOGY},
  keyword      = {N-glycan profile,NUCLEOTIDE EXCISION-REPAIR,Age-related disease,Ageing,Biomarker,BODY-MASS INDEX,COCKAYNE-SYNDROME,HEPATOCELLULAR-CARCINOMA,GENETIC POLYMORPHISMS,GLYCOMIC CHANGES,DISEASE,CIRRHOSIS,DEMENTIA,GLYCOSYLATION},
  language     = {eng},
  number       = {10},
  pages        = {738--743},
  title        = {Serum N-glycan profile shift during human ageing},
  url          = {http://dx.doi.org/10.1016/j.exger.2010.08.009},
  volume       = {45},
  year         = {2010},
}

Chicago
Vanhooren, Valerie, Sylviane Dewaele, Claude Libert, Sebastiaan Engelborghs, Peter Paul De Deyn, Olivier Toussaint, Florence Debacq-Chainiaux, et al. 2010. “Serum N-glycan Profile Shift During Human Ageing.” Experimental Gerontology 45 (10): 738–743.
APA
Vanhooren, V., Dewaele, S., Libert, C., Engelborghs, S., De Deyn, P. P., Toussaint, O., Debacq-Chainiaux, F., et al. (2010). Serum N-glycan profile shift during human ageing. EXPERIMENTAL GERONTOLOGY, 45(10), 738–743.
Vancouver
1.
Vanhooren V, Dewaele S, Libert C, Engelborghs S, De Deyn PP, Toussaint O, et al. Serum N-glycan profile shift during human ageing. EXPERIMENTAL GERONTOLOGY. 2010;45(10):738–43.
MLA
Vanhooren, Valerie, Sylviane Dewaele, Claude Libert, et al. “Serum N-glycan Profile Shift During Human Ageing.” EXPERIMENTAL GERONTOLOGY 45.10 (2010): 738–743. Print.