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Evaluation of injection molding as a pharmaceutical production technology for sustained-release matrix tablets

Thomas Quinten UGent (2010)
abstract
Injection molding (IM) originated from and has been widely used in the plastic processing industry for numerous applications, but is a relatively new technique to the pharmaceutical industry and academia as drug delivery technology. This work aimed at developing sustained release formulations that provided time-independent release kinetics, and to ascertain the sustained release properties of these injection molded tablets with respect to drug release kinetics and release mechanisms, combined with a profound characterization of active ingredients and excipients prior to production, and solid-state characteristics of molded tablets after manufacturing. Finally, the in vivo performance in dogs was assessed. It can be concluded that injection molding is a promising and versatile production technology for the manufacturing of sustained release matrix tablets, using different polymeric carriers to reduce the release rate of a good water soluble drug.
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
keyword
polymers, injection molding, matrix tablets
pages
VI, 216 pages
publisher
Ghent University. Faculty of Pharmaceutical Sciences
place of publication
Ghent, Belgium
defense location
Gent : Farmaceutisch Instituut (auditorium II)
defense date
2010-11-24 17:00
language
English
UGent publication?
yes
classification
D1
additional info
dissertation consists of copyrighted materials
copyright statement
I have transferred the copyright for this publication to the publisher
id
1081904
handle
http://hdl.handle.net/1854/LU-1081904
date created
2010-12-03 13:10:08
date last changed
2010-12-03 13:46:29
@phdthesis{1081904,
  abstract     = {Injection molding (IM) originated from and has been widely used in the plastic processing industry for numerous applications, but is a relatively new technique to the pharmaceutical industry and academia as drug delivery technology. This work aimed at developing sustained release formulations that provided time-independent release kinetics, and to ascertain the sustained release properties of these injection molded tablets with respect to drug release kinetics and release mechanisms, combined with a profound characterization of active ingredients and excipients prior to production, and solid-state characteristics of molded tablets after manufacturing. Finally, the in vivo performance in dogs was assessed.
It can be concluded that injection molding is a promising and versatile production technology for the manufacturing of sustained release matrix tablets, using different polymeric carriers to reduce the release rate of a good water soluble drug.},
  author       = {Quinten, Thomas},
  keyword      = {polymers,injection molding,matrix tablets},
  language     = {eng},
  pages        = {VI, 216},
  publisher    = {Ghent University. Faculty of Pharmaceutical Sciences},
  school       = {Ghent University},
  title        = {Evaluation of injection molding as a pharmaceutical production technology for sustained-release matrix tablets},
  year         = {2010},
}

Chicago
Quinten, Thomas. 2010. “Evaluation of Injection Molding as a Pharmaceutical Production Technology for Sustained-release Matrix Tablets”. Ghent, Belgium: Ghent University. Faculty of Pharmaceutical Sciences.
APA
Quinten, T. (2010). Evaluation of injection molding as a pharmaceutical production technology for sustained-release matrix tablets. Ghent University. Faculty of Pharmaceutical Sciences, Ghent, Belgium.
Vancouver
1.
Quinten T. Evaluation of injection molding as a pharmaceutical production technology for sustained-release matrix tablets. [Ghent, Belgium]: Ghent University. Faculty of Pharmaceutical Sciences; 2010.
MLA
Quinten, Thomas. “Evaluation of Injection Molding as a Pharmaceutical Production Technology for Sustained-release Matrix Tablets.” 2010 : n. pag. Print.