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Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma

Claus Bachert UGent, Nan Zhang UGent, Gabriële Holtappels UGent, Lizzy De Lobel UGent, Paul Van Cauwenberge UGent, ShiXi Liu, Ping Lin, Jean Bousquet and Kristel Van Steen UGent (2010) JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 126(5). p.962-968
abstract
Background: Nasal polyps often are associated with asthma. The phenotype of these patients is unknown. Objective: To identify the mucosal factors associated with asthma comorbidity, we analyzed the inflammatory patterns of nasal polyps. Methods: Nasal polyps from 70 Belgian patients, 34% with asthma, were analyzed for type of inflammation, T-cell cytokines, and IgE antibodies to Staphylococcus aureus enterotoxins. The same investigations were repeated in 93 Chinese patients with polyps, a group with a low asthma comorbidity rate (8%). Results: In Belgian patients with polyps, 54% of samples showed eosinophilic inflammation. A classification tree evaluation identified IL-5 as the main positive determinant. Enterotoxin IgE in tissue (37%) was associated with significantly increased total IgE and eosinophil cationic protein concentrations. Expression of enterotoxin IgE, total IgE at greater than 1,442 kU/L, and eosinophil cationic protein at greater than 17,109 mu g/L in samples with a total IgE concentration of greater than 246 kU/L significantly predicted asthma (odds ratio, 5.8-13). Only 7.5% of the samples from Chinese patients with polyps showed eosinophilic inflammation. IL-5 was confirmed as a positive determinant of eosinophilic inflammation, and enterotoxin IgE in tissue (17% of patients) was associated with significantly increased total IgE and eosinophil cationic protein concentrations. The expression of IL-5 or total IgE at greater than 790 kU/L in samples with an IL-5 concentration of greater than 194 pg/mL significantly predicted comorbid asthma (odds ratio, 17.2-96). Conclusion: Mucosal inflammation in nasal polyps orchestrated by T(H)2 cytokines and amplified by S aureus enterotoxins is characterized by an increased eosinophilic inflammation and formation of IgE antibodies. This phenotype is associated with comorbid asthma in white and Asian patients with nasal polyps.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
nasal polyps, Chronic rhinosinusitis, asthma, T-cell cytokines, Staphylococcus aureus enterotoxins, IgE, SINUS DISEASE, T-CELLS, RHINOSINUSITIS, SUPERANTIGENS, INFLAMMATION
journal title
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
J. Allergy Clin. Immunol.
volume
126
issue
5
pages
962 - 968
Web of Science type
Article
Web of Science id
000283727100011
JCR category
ALLERGY
JCR impact factor
9.273 (2010)
JCR rank
1/20 (2010)
JCR quartile
1 (2010)
ISSN
0091-6749
DOI
10.1016/j.jaci.2010.07.007
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1081031
handle
http://hdl.handle.net/1854/LU-1081031
date created
2010-11-30 15:57:49
date last changed
2010-12-01 17:03:30
@article{1081031,
  abstract     = {Background: Nasal polyps often are associated with asthma. The phenotype of these patients is unknown.
Objective: To identify the mucosal factors associated with asthma comorbidity, we analyzed the inflammatory patterns of nasal polyps.
Methods: Nasal polyps from 70 Belgian patients, 34\% with asthma, were analyzed for type of inflammation, T-cell cytokines, and IgE antibodies to Staphylococcus aureus enterotoxins. The same investigations were repeated in 93 Chinese patients with polyps, a group with a low asthma comorbidity rate (8\%).
Results: In Belgian patients with polyps, 54\% of samples showed eosinophilic inflammation. A classification tree evaluation identified IL-5 as the main positive determinant. Enterotoxin IgE in tissue (37\%) was associated with significantly increased total IgE and eosinophil cationic protein concentrations. Expression of enterotoxin IgE, total IgE at greater than 1,442 kU/L, and eosinophil cationic protein at greater than 17,109 mu g/L in samples with a total IgE concentration of greater than 246 kU/L significantly predicted asthma (odds ratio, 5.8-13). Only 7.5\% of the samples from Chinese patients with polyps showed eosinophilic inflammation. IL-5 was confirmed as a positive determinant of eosinophilic inflammation, and enterotoxin IgE in tissue (17\% of patients) was associated with significantly increased total IgE and eosinophil cationic protein concentrations. The expression of IL-5 or total IgE at greater than 790 kU/L in samples with an IL-5 concentration of greater than 194 pg/mL significantly predicted comorbid asthma (odds ratio, 17.2-96).
Conclusion: Mucosal inflammation in nasal polyps orchestrated by T(H)2 cytokines and amplified by S aureus enterotoxins is characterized by an increased eosinophilic inflammation and formation of IgE antibodies. This phenotype is associated with comorbid asthma in white and Asian patients with nasal polyps.},
  author       = {Bachert, Claus and Zhang, Nan and Holtappels, Gabri{\"e}le and De Lobel, Lizzy and Van Cauwenberge, Paul and Liu, ShiXi and Lin, Ping and Bousquet, Jean and Van Steen, Kristel},
  issn         = {0091-6749},
  journal      = {JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY},
  keyword      = {nasal polyps,Chronic rhinosinusitis,asthma,T-cell cytokines,Staphylococcus aureus enterotoxins,IgE,SINUS DISEASE,T-CELLS,RHINOSINUSITIS,SUPERANTIGENS,INFLAMMATION},
  language     = {eng},
  number       = {5},
  pages        = {962--968},
  title        = {Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma},
  url          = {http://dx.doi.org/10.1016/j.jaci.2010.07.007},
  volume       = {126},
  year         = {2010},
}

Chicago
Bachert, Claus, Nan Zhang, Gabriële Holtappels, Lizzy De Lobel, Paul Van Cauwenberge, ShiXi Liu, Ping Lin, Jean Bousquet, and Kristel Van Steen. 2010. “Presence of IL-5 Protein and IgE Antibodies to Staphylococcal Enterotoxins in Nasal Polyps Is Associated with Comorbid Asthma.” Journal of Allergy and Clinical Immunology 126 (5): 962–968.
APA
Bachert, C., Zhang, N., Holtappels, G., De Lobel, L., Van Cauwenberge, P., Liu, S., Lin, P., et al. (2010). Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 126(5), 962–968.
Vancouver
1.
Bachert C, Zhang N, Holtappels G, De Lobel L, Van Cauwenberge P, Liu S, et al. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;126(5):962–8.
MLA
Bachert, Claus, Nan Zhang, Gabriële Holtappels, et al. “Presence of IL-5 Protein and IgE Antibodies to Staphylococcal Enterotoxins in Nasal Polyps Is Associated with Comorbid Asthma.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 126.5 (2010): 962–968. Print.