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Reduction of high-energy phosphates in the occipital lobe of migraine without aura patients: a 31P- and 1H-MRS study

Harmen Reyngoudt UGent, Koen Paemeleire UGent, Benedicte Descamps UGent, Yves De Deene UGent and Eric Achten UGent (2010) JOURNAL OF HEADACHE AND PAIN. 11(suppl. 1). p.S39-S39
abstract
Introduction: Magnetic resonance spectroscopy (MRS), a technique to obtain biochemical information non-invasively, has been used in several migraine studies. Both proton MRS (1H-MRS) and phosphorus MRS (31P-MRS) studies were mainly performed in migraine with aura. Aim: The aim of this study was to perform absolute quantification of metabolites with 31P-MRS and 1H-MRS in a homogeneous group of migraine without aura (MO) patients, who were not on prophylaxis. We were especially interested in the resting state brain energy metabolism of these MO patients. Methods and subjects: We compared 22 MO patients with 25 age but not gender-matched controls. Patients experienced 2-8 attacks per month, were not using any prophylactic medication and were headache-free for at least 48 hours. MRS Spectra were acquired in the medial occipital lobe on a 3 T Siemens TrioTim system. Spectra were analyzed using jMRUI and Siemens software. Absolute quantification was performed using an external reference. Results: A significantly decreased phosphocreatine (PCr) was found in MO versus controls (4.09 ± 0.58 mM versus 4.85 ± 0.60 mM resp.; P = 0.001) and has been previously reported. Whereas adenosine triphosphate (ATP) was considered to be constant in previously published work, we found a significant decrease in ATP in MO patients versus controls (2.33 ± 0.63 mM versus 2.76 ± 0.59 mM resp.; P = 0.023). No significant changes in inorganic phosphate, adenosine diphosphate, pH and magnesium were found betweenMO patients and controls. Also no significant differences in proton metabolites (N-acetyl aspartate, creatine, choline, myo-inositol)were observed between MO patients and controls. 1H-MRS did not show any quantifiable lactate in all subjects. Discussion: 31P-MRS demonstrated a significant decrease in the high-energy phosphates ATP and PCr in (a subgroup of) MO patients, implying impaired resting state brain energy metabolism and further pointing at a mitochondrial component in the pathophysiology.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
migraine without aura, pathophysiology, 1H-MRS, 31P-MRS, energy metabolism, mitochondrial
in
JOURNAL OF HEADACHE AND PAIN
J. Headache Pain
volume
11
issue
suppl. 1
article_number
abstract 195
pages
S39 - S39
conference name
2nd European Headache and Migraine Trust international congress (EHMTIC 2010)
conference location
Nice, France
conference start
2010-10-28
conference end
2010-10-31
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.015 (2010)
JCR rank
91/185 (2010)
JCR quartile
2 (2010)
ISSN
1129-2369
language
English
UGent publication?
yes
classification
C3
id
1079637
handle
http://hdl.handle.net/1854/LU-1079637
alternative location
http://www.springerlink.com/content/1129-2369/11/s1/
date created
2010-11-25 19:12:00
date last changed
2010-11-26 08:56:28
@inproceedings{1079637,
  abstract     = {Introduction: Magnetic resonance spectroscopy (MRS), a technique to obtain biochemical information non-invasively, has been used in several migraine studies. Both proton MRS (1H-MRS) and phosphorus MRS (31P-MRS) studies were mainly performed in migraine with aura.
Aim: The aim of this study was to perform absolute quantification of metabolites with 31P-MRS and 1H-MRS in a homogeneous group of migraine without aura (MO) patients, who were not on prophylaxis. We were especially interested in the resting state brain energy metabolism of these MO patients.
Methods and subjects: We compared 22 MO patients with 25 age but not gender-matched controls. Patients experienced 2-8 attacks per month, were not using any prophylactic medication and were headache-free for at least 48 hours. MRS Spectra were acquired in the medial occipital lobe on a 3 T Siemens TrioTim system. Spectra were analyzed using jMRUI and Siemens software. Absolute quantification was performed using an external reference.
Results: A significantly decreased phosphocreatine (PCr) was found in MO versus controls (4.09 {\textpm} 0.58 mM versus 4.85 {\textpm} 0.60 mM resp.; P = 0.001) and has been previously reported. Whereas adenosine triphosphate (ATP) was considered to be constant in previously published work, we found a significant decrease in ATP in MO patients versus controls (2.33 {\textpm} 0.63 mM versus 2.76 {\textpm} 0.59 mM resp.; P = 0.023). No significant changes in inorganic phosphate, adenosine diphosphate, pH and magnesium were found betweenMO patients and controls. Also no significant differences in proton metabolites (N-acetyl aspartate, creatine, choline, myo-inositol)were observed between MO patients and controls. 1H-MRS did not show any quantifiable lactate in all subjects.
Discussion: 31P-MRS demonstrated a significant decrease in the high-energy phosphates ATP and PCr in (a subgroup of) MO patients, implying impaired resting state brain energy metabolism and further pointing at a mitochondrial component in the pathophysiology.},
  articleno    = {abstract 195},
  author       = {Reyngoudt, Harmen and Paemeleire, Koen and Descamps, Benedicte and De Deene, Yves and Achten, Eric},
  booktitle    = {JOURNAL OF HEADACHE AND PAIN},
  issn         = {1129-2369},
  keyword      = {migraine without aura,pathophysiology,1H-MRS,31P-MRS,energy metabolism,mitochondrial},
  language     = {eng},
  location     = {Nice, France},
  number       = {suppl. 1},
  pages        = {abstract 195:S39--abstract 195:S39},
  title        = {Reduction of high-energy phosphates in the occipital lobe of migraine without aura patients: a 31P- and 1H-MRS study},
  url          = {http://www.springerlink.com/content/1129-2369/11/s1/},
  volume       = {11},
  year         = {2010},
}

Chicago
Reyngoudt, Harmen, Koen Paemeleire, Benedicte Descamps, Yves De Deene, and Eric Achten. 2010. “Reduction of High-energy Phosphates in the Occipital Lobe of Migraine Without Aura Patients: a 31P- and 1H-MRS Study.” In Journal of Headache and Pain, 11:S39–S39.
APA
Reyngoudt, H., Paemeleire, K., Descamps, B., De Deene, Y., & Achten, E. (2010). Reduction of high-energy phosphates in the occipital lobe of migraine without aura patients: a 31P- and 1H-MRS study. JOURNAL OF HEADACHE AND PAIN (Vol. 11, pp. S39–S39). Presented at the 2nd European Headache and Migraine Trust international congress (EHMTIC 2010).
Vancouver
1.
Reyngoudt H, Paemeleire K, Descamps B, De Deene Y, Achten E. Reduction of high-energy phosphates in the occipital lobe of migraine without aura patients: a 31P- and 1H-MRS study. JOURNAL OF HEADACHE AND PAIN. 2010. p. S39–S39.
MLA
Reyngoudt, Harmen, Koen Paemeleire, Benedicte Descamps, et al. “Reduction of High-energy Phosphates in the Occipital Lobe of Migraine Without Aura Patients: a 31P- and 1H-MRS Study.” Journal of Headache and Pain. Vol. 11. 2010. S39–S39. Print.