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Reduction of high-energy phosphates in the occipital lobe of migraine without aura patients: a 31P- and 1H-MRS study

Harmen Reyngoudt (UGent) , Koen Paemeleire (UGent) , Benedicte Descamps (UGent) , Yves De Deene (UGent) and Eric Achten (UGent)
(2010) JOURNAL OF HEADACHE AND PAIN. 11(suppl. 1). p.S39-S39
Author
Organization
Abstract
Introduction: Magnetic resonance spectroscopy (MRS), a technique to obtain biochemical information non-invasively, has been used in several migraine studies. Both proton MRS (1H-MRS) and phosphorus MRS (31P-MRS) studies were mainly performed in migraine with aura. Aim: The aim of this study was to perform absolute quantification of metabolites with 31P-MRS and 1H-MRS in a homogeneous group of migraine without aura (MO) patients, who were not on prophylaxis. We were especially interested in the resting state brain energy metabolism of these MO patients. Methods and subjects: We compared 22 MO patients with 25 age but not gender-matched controls. Patients experienced 2-8 attacks per month, were not using any prophylactic medication and were headache-free for at least 48 hours. MRS Spectra were acquired in the medial occipital lobe on a 3 T Siemens TrioTim system. Spectra were analyzed using jMRUI and Siemens software. Absolute quantification was performed using an external reference. Results: A significantly decreased phosphocreatine (PCr) was found in MO versus controls (4.09 ± 0.58 mM versus 4.85 ± 0.60 mM resp.; P = 0.001) and has been previously reported. Whereas adenosine triphosphate (ATP) was considered to be constant in previously published work, we found a significant decrease in ATP in MO patients versus controls (2.33 ± 0.63 mM versus 2.76 ± 0.59 mM resp.; P = 0.023). No significant changes in inorganic phosphate, adenosine diphosphate, pH and magnesium were found betweenMO patients and controls. Also no significant differences in proton metabolites (N-acetyl aspartate, creatine, choline, myo-inositol)were observed between MO patients and controls. 1H-MRS did not show any quantifiable lactate in all subjects. Discussion: 31P-MRS demonstrated a significant decrease in the high-energy phosphates ATP and PCr in (a subgroup of) MO patients, implying impaired resting state brain energy metabolism and further pointing at a mitochondrial component in the pathophysiology.
Keywords
migraine without aura, pathophysiology, 1H-MRS, 31P-MRS, energy metabolism, mitochondrial

Citation

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Chicago
Reyngoudt, Harmen, Koen Paemeleire, Benedicte Descamps, Yves De Deene, and Eric Achten. 2010. “Reduction of High-energy Phosphates in the Occipital Lobe of Migraine Without Aura Patients: a 31P- and 1H-MRS Study.” In Journal of Headache and Pain, 11:S39–S39.
APA
Reyngoudt, H., Paemeleire, K., Descamps, B., De Deene, Y., & Achten, E. (2010). Reduction of high-energy phosphates in the occipital lobe of migraine without aura patients: a 31P- and 1H-MRS study. JOURNAL OF HEADACHE AND PAIN (Vol. 11, pp. S39–S39). Presented at the 2nd European Headache and Migraine Trust international congress (EHMTIC 2010).
Vancouver
1.
Reyngoudt H, Paemeleire K, Descamps B, De Deene Y, Achten E. Reduction of high-energy phosphates in the occipital lobe of migraine without aura patients: a 31P- and 1H-MRS study. JOURNAL OF HEADACHE AND PAIN. 2010. p. S39–S39.
MLA
Reyngoudt, Harmen, Koen Paemeleire, Benedicte Descamps, et al. “Reduction of High-energy Phosphates in the Occipital Lobe of Migraine Without Aura Patients: a 31P- and 1H-MRS Study.” Journal of Headache and Pain. Vol. 11. 2010. S39–S39. Print.
@inproceedings{1079637,
  abstract     = {Introduction: Magnetic resonance spectroscopy (MRS), a technique to obtain biochemical information non-invasively, has been used in several migraine studies. Both proton MRS (1H-MRS) and phosphorus MRS (31P-MRS) studies were mainly performed in migraine with aura.
Aim: The aim of this study was to perform absolute quantification of metabolites with 31P-MRS and 1H-MRS in a homogeneous group of migraine without aura (MO) patients, who were not on prophylaxis. We were especially interested in the resting state brain energy metabolism of these MO patients.
Methods and subjects: We compared 22 MO patients with 25 age but not gender-matched controls. Patients experienced 2-8 attacks per month, were not using any prophylactic medication and were headache-free for at least 48 hours. MRS Spectra were acquired in the medial occipital lobe on a 3 T Siemens TrioTim system. Spectra were analyzed using jMRUI and Siemens software. Absolute quantification was performed using an external reference.
Results: A significantly decreased phosphocreatine (PCr) was found in MO versus controls (4.09 {\textpm} 0.58 mM versus 4.85 {\textpm} 0.60 mM resp.; P = 0.001) and has been previously reported. Whereas adenosine triphosphate (ATP) was considered to be constant in previously published work, we found a significant decrease in ATP in MO patients versus controls (2.33 {\textpm} 0.63 mM versus 2.76 {\textpm} 0.59 mM resp.; P = 0.023). No significant changes in inorganic phosphate, adenosine diphosphate, pH and magnesium were found betweenMO patients and controls. Also no significant differences in proton metabolites (N-acetyl aspartate, creatine, choline, myo-inositol)were observed between MO patients and controls. 1H-MRS did not show any quantifiable lactate in all subjects.
Discussion: 31P-MRS demonstrated a significant decrease in the high-energy phosphates ATP and PCr in (a subgroup of) MO patients, implying impaired resting state brain energy metabolism and further pointing at a mitochondrial component in the pathophysiology.},
  articleno    = {abstract 195},
  author       = {Reyngoudt, Harmen and Paemeleire, Koen and Descamps, Benedicte and De Deene, Yves and Achten, Eric},
  booktitle    = {JOURNAL OF HEADACHE AND PAIN},
  issn         = {1129-2369},
  language     = {eng},
  location     = {Nice, France},
  number       = {suppl. 1},
  pages        = {abstract 195:S39--abstract 195:S39},
  title        = {Reduction of high-energy phosphates in the occipital lobe of migraine without aura patients: a 31P- and 1H-MRS study},
  url          = {http://www.springerlink.com/content/1129-2369/11/s1/},
  volume       = {11},
  year         = {2010},
}