Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice
- Author
- Soheila Shirinbak, Yousef A Taher, Hadi Maazi, Renee Gras, Betty CAM van Esch, Paul AJ Henricks, Janneke N Samsom, J Sjef Verbeek, Bart Lambrecht (UGent) , Antoon JM van Oosterhout and Martijn C Nawijn
- Organization
- Abstract
- Allergen-specific immunotherapy (IT) uniquely renders long-term relief from allergic symptoms and is associated with elevated serum levels of allergen-specific IgG and IgA. The allergen-specific IgG response induced by IT treatment was shown to be critical for suppression of the immediate phase of the allergic response in mice, and this suppression was partially dependent on signaling through Fc gamma RIIB. To investigate the relevance of the allergen-specific IgG responses for suppression of the Th2-driven late-phase allergic response, we performed IT in a mouse model of allergic asthma in the absence of FcgRIIB or Fc gamma RI/Fc gamma RIII signaling. We found that suppression of Th2 cell activity, allergic inflammation, and allergen-specific IgE responses is independent of Fc gamma RIIB and Fc gamma RI/Fc gamma RIII signaling. Moreover, we show that the IT-induced allergen-specific systemic IgG or IgA responses and B cell function are dispensable for suppression of the late-phase allergic response by IT treatment. Finally, we found that the secretory mucosal IgA response also is not required for suppression of the Th2-driven allergic inflammation by IT. These data are in contrast to the suppression of the immediate phase of the allergic response, which is critically dependent on the induced allergen-specific serum IgG response. Hence, IT-induced suppression of the immediate and late phases of the allergic response is governed by divergent and independent mechanisms. Our data show that the IT-induced suppression of the Th2 cell-dependent late-phase allergic response is independent of the allergen-specific IgG and IgA responses that are associated with IT treatment.
- Keywords
- EXPRESSION, TOLERANCE, MOUSE MODEL, DENDRITIC CELLS, BLOCKING ANTIBODY, TGF-BETA, MURINE MODEL, DEFICIENT MICE, FC-GAMMA-RIIB, GRASS-POLLEN IMMUNOTHERAPY
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1077821
- MLA
- Shirinbak, Soheila, et al. “Suppression of Th2-Driven Airway Inflammation by Allergen Immunotherapy Is Independent of B Cell and Ig Responses in Mice.” JOURNAL OF IMMUNOLOGY, vol. 185, no. 7, 2010, pp. 3857–65, doi:10.4049/jimmunol.0903909.
- APA
- Shirinbak, S., Taher, Y. A., Maazi, H., Gras, R., van Esch, B. C., Henricks, P. A., … Nawijn, M. C. (2010). Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice. JOURNAL OF IMMUNOLOGY, 185(7), 3857–3865. https://doi.org/10.4049/jimmunol.0903909
- Chicago author-date
- Shirinbak, Soheila, Yousef A Taher, Hadi Maazi, Renee Gras, Betty CAM van Esch, Paul AJ Henricks, Janneke N Samsom, et al. 2010. “Suppression of Th2-Driven Airway Inflammation by Allergen Immunotherapy Is Independent of B Cell and Ig Responses in Mice.” JOURNAL OF IMMUNOLOGY 185 (7): 3857–65. https://doi.org/10.4049/jimmunol.0903909.
- Chicago author-date (all authors)
- Shirinbak, Soheila, Yousef A Taher, Hadi Maazi, Renee Gras, Betty CAM van Esch, Paul AJ Henricks, Janneke N Samsom, J Sjef Verbeek, Bart Lambrecht, Antoon JM van Oosterhout, and Martijn C Nawijn. 2010. “Suppression of Th2-Driven Airway Inflammation by Allergen Immunotherapy Is Independent of B Cell and Ig Responses in Mice.” JOURNAL OF IMMUNOLOGY 185 (7): 3857–3865. doi:10.4049/jimmunol.0903909.
- Vancouver
- 1.Shirinbak S, Taher YA, Maazi H, Gras R, van Esch BC, Henricks PA, et al. Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice. JOURNAL OF IMMUNOLOGY. 2010;185(7):3857–65.
- IEEE
- [1]S. Shirinbak et al., “Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice,” JOURNAL OF IMMUNOLOGY, vol. 185, no. 7, pp. 3857–3865, 2010.
@article{1077821, abstract = {{Allergen-specific immunotherapy (IT) uniquely renders long-term relief from allergic symptoms and is associated with elevated serum levels of allergen-specific IgG and IgA. The allergen-specific IgG response induced by IT treatment was shown to be critical for suppression of the immediate phase of the allergic response in mice, and this suppression was partially dependent on signaling through Fc gamma RIIB. To investigate the relevance of the allergen-specific IgG responses for suppression of the Th2-driven late-phase allergic response, we performed IT in a mouse model of allergic asthma in the absence of FcgRIIB or Fc gamma RI/Fc gamma RIII signaling. We found that suppression of Th2 cell activity, allergic inflammation, and allergen-specific IgE responses is independent of Fc gamma RIIB and Fc gamma RI/Fc gamma RIII signaling. Moreover, we show that the IT-induced allergen-specific systemic IgG or IgA responses and B cell function are dispensable for suppression of the late-phase allergic response by IT treatment. Finally, we found that the secretory mucosal IgA response also is not required for suppression of the Th2-driven allergic inflammation by IT. These data are in contrast to the suppression of the immediate phase of the allergic response, which is critically dependent on the induced allergen-specific serum IgG response. Hence, IT-induced suppression of the immediate and late phases of the allergic response is governed by divergent and independent mechanisms. Our data show that the IT-induced suppression of the Th2 cell-dependent late-phase allergic response is independent of the allergen-specific IgG and IgA responses that are associated with IT treatment.}}, author = {{Shirinbak, Soheila and Taher, Yousef A and Maazi, Hadi and Gras, Renee and van Esch, Betty CAM and Henricks, Paul AJ and Samsom, Janneke N and Verbeek, J Sjef and Lambrecht, Bart and van Oosterhout, Antoon JM and Nawijn, Martijn C}}, issn = {{0022-1767}}, journal = {{JOURNAL OF IMMUNOLOGY}}, keywords = {{EXPRESSION,TOLERANCE,MOUSE MODEL,DENDRITIC CELLS,BLOCKING ANTIBODY,TGF-BETA,MURINE MODEL,DEFICIENT MICE,FC-GAMMA-RIIB,GRASS-POLLEN IMMUNOTHERAPY}}, language = {{eng}}, number = {{7}}, pages = {{3857--3865}}, title = {{Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice}}, url = {{http://doi.org/10.4049/jimmunol.0903909}}, volume = {{185}}, year = {{2010}}, }
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