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The role of dendritic and epithelial cells as master regulators of allergic airway inflammation

Bart Lambrecht UGent and Hamida Hammad UGent (2010) LANCET. 376(9743). p.835-843
abstract
Lung dendritic cells bridge innate and adaptive immunity, integrating a variety of stimuli from allergens, microbial colonisation, environmental pollution, and innate immune cells into a signal for T lymphocytes of the adaptive immune system. Dendritic cells have a pivotal role in the activation of T helper (Th) 2 cells and allergic inflammation. Lung dendritic cells can also prevent harmful immune responses to innocuous inhaled antigens via induction of regulatory T cells or Th1 cells. In our Review, we discuss how understanding the biology of dendritic cells is crucial for understanding the interaction between allergens, the environment, and genetics, and focus on how dendritic cells conspire with airway epithelial cells and innate pro-Th2 cells to cause allergic sensitisation and asthma.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
CIGARETTE-SMOKE, LYMPH-NODES, INHALED ANTIGEN, IMMUNE-RESPONSES, CD4(+) T-CELLS, RESPIRATORY SYNCYTIAL VIRUS, HOUSE-DUST MITE, THYMIC STROMAL LYMPHOPOIETIN, IN-VIVO, EXPERIMENTAL ASTHMA
journal title
LANCET
Lancet
volume
376
issue
9743
pages
835 - 843
Web of Science type
Review
Web of Science id
000281831000035
JCR category
MEDICINE, GENERAL & INTERNAL
JCR impact factor
33.633 (2010)
JCR rank
2/151 (2010)
JCR quartile
1 (2010)
ISSN
0140-6736
DOI
10.1016/S0140-6736(10)61226-3
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1077774
handle
http://hdl.handle.net/1854/LU-1077774
date created
2010-11-22 14:39:43
date last changed
2016-12-19 15:44:33
@article{1077774,
  abstract     = {Lung dendritic cells bridge innate and adaptive immunity, integrating a variety of stimuli from allergens, microbial colonisation, environmental pollution, and innate immune cells into a signal for T lymphocytes of the adaptive immune system. Dendritic cells have a pivotal role in the activation of T helper (Th) 2 cells and allergic inflammation. Lung dendritic cells can also prevent harmful immune responses to innocuous inhaled antigens via induction of regulatory T cells or Th1 cells. In our Review, we discuss how understanding the biology of dendritic cells is crucial for understanding the interaction between allergens, the environment, and genetics, and focus on how dendritic cells conspire with airway epithelial cells and innate pro-Th2 cells to cause allergic sensitisation and asthma.},
  author       = {Lambrecht, Bart and Hammad, Hamida},
  issn         = {0140-6736},
  journal      = {LANCET},
  keyword      = {CIGARETTE-SMOKE,LYMPH-NODES,INHALED ANTIGEN,IMMUNE-RESPONSES,CD4(+) T-CELLS,RESPIRATORY SYNCYTIAL VIRUS,HOUSE-DUST MITE,THYMIC STROMAL LYMPHOPOIETIN,IN-VIVO,EXPERIMENTAL ASTHMA},
  language     = {eng},
  number       = {9743},
  pages        = {835--843},
  title        = {The role of dendritic and epithelial cells as master regulators of allergic airway inflammation},
  url          = {http://dx.doi.org/10.1016/S0140-6736(10)61226-3},
  volume       = {376},
  year         = {2010},
}

Chicago
Lambrecht, Bart, and Hamida Hammad. 2010. “The Role of Dendritic and Epithelial Cells as Master Regulators of Allergic Airway Inflammation.” Lancet 376 (9743): 835–843.
APA
Lambrecht, Bart, & Hammad, H. (2010). The role of dendritic and epithelial cells as master regulators of allergic airway inflammation. LANCET, 376(9743), 835–843.
Vancouver
1.
Lambrecht B, Hammad H. The role of dendritic and epithelial cells as master regulators of allergic airway inflammation. LANCET. 2010;376(9743):835–43.
MLA
Lambrecht, Bart, and Hamida Hammad. “The Role of Dendritic and Epithelial Cells as Master Regulators of Allergic Airway Inflammation.” LANCET 376.9743 (2010): 835–843. Print.