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The role of dendritic and epithelial cells as master regulators of allergic airway inflammation

Bart Lambrecht (UGent) and Hamida Hammad (UGent)
(2010) LANCET. 376(9743). p.835-843
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Abstract
Lung dendritic cells bridge innate and adaptive immunity, integrating a variety of stimuli from allergens, microbial colonisation, environmental pollution, and innate immune cells into a signal for T lymphocytes of the adaptive immune system. Dendritic cells have a pivotal role in the activation of T helper (Th) 2 cells and allergic inflammation. Lung dendritic cells can also prevent harmful immune responses to innocuous inhaled antigens via induction of regulatory T cells or Th1 cells. In our Review, we discuss how understanding the biology of dendritic cells is crucial for understanding the interaction between allergens, the environment, and genetics, and focus on how dendritic cells conspire with airway epithelial cells and innate pro-Th2 cells to cause allergic sensitisation and asthma.
Keywords
CIGARETTE-SMOKE, LYMPH-NODES, INHALED ANTIGEN, IMMUNE-RESPONSES, CD4(+) T-CELLS, RESPIRATORY SYNCYTIAL VIRUS, HOUSE-DUST MITE, THYMIC STROMAL LYMPHOPOIETIN, IN-VIVO, EXPERIMENTAL ASTHMA

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Chicago
Lambrecht, Bart, and Hamida Hammad. 2010. “The Role of Dendritic and Epithelial Cells as Master Regulators of Allergic Airway Inflammation.” Lancet 376 (9743): 835–843.
APA
Lambrecht, Bart, & Hammad, H. (2010). The role of dendritic and epithelial cells as master regulators of allergic airway inflammation. LANCET, 376(9743), 835–843.
Vancouver
1.
Lambrecht B, Hammad H. The role of dendritic and epithelial cells as master regulators of allergic airway inflammation. LANCET. 2010;376(9743):835–43.
MLA
Lambrecht, Bart, and Hamida Hammad. “The Role of Dendritic and Epithelial Cells as Master Regulators of Allergic Airway Inflammation.” LANCET 376.9743 (2010): 835–843. Print.
@article{1077774,
  abstract     = {Lung dendritic cells bridge innate and adaptive immunity, integrating a variety of stimuli from allergens, microbial colonisation, environmental pollution, and innate immune cells into a signal for T lymphocytes of the adaptive immune system. Dendritic cells have a pivotal role in the activation of T helper (Th) 2 cells and allergic inflammation. Lung dendritic cells can also prevent harmful immune responses to innocuous inhaled antigens via induction of regulatory T cells or Th1 cells. In our Review, we discuss how understanding the biology of dendritic cells is crucial for understanding the interaction between allergens, the environment, and genetics, and focus on how dendritic cells conspire with airway epithelial cells and innate pro-Th2 cells to cause allergic sensitisation and asthma.},
  author       = {Lambrecht, Bart and Hammad, Hamida},
  issn         = {0140-6736},
  journal      = {LANCET},
  keyword      = {CIGARETTE-SMOKE,LYMPH-NODES,INHALED ANTIGEN,IMMUNE-RESPONSES,CD4(+) T-CELLS,RESPIRATORY SYNCYTIAL VIRUS,HOUSE-DUST MITE,THYMIC STROMAL LYMPHOPOIETIN,IN-VIVO,EXPERIMENTAL ASTHMA},
  language     = {eng},
  number       = {9743},
  pages        = {835--843},
  title        = {The role of dendritic and epithelial cells as master regulators of allergic airway inflammation},
  url          = {http://dx.doi.org/10.1016/S0140-6736(10)61226-3},
  volume       = {376},
  year         = {2010},
}

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