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Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

Hamida Hammad (UGent) , Maud Plantinga (UGent) , Kim Deswarte (UGent) , Philippe Pouliot (UGent) , Monique Willart (UGent) , Mirjam Kool (UGent) , Femke Muskens and Bart Lambrecht (UGent)
(2010) JOURNAL OF EXPERIMENTAL MEDICINE. 207(10). p.2097-2111
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Organization
Abstract
It is unclear how Th2 immunity is induced in response to allergens like house dust mite (HDM). Here, we show that HDM inhalation leads to the TLR4/MyD88-dependent recruitment of IL-4 competent basophils and eosinophils, and of inflammatory DCs to the draining mediastinal nodes. Depletion of basophils only partially reduced Th2 immunity, and depletion of eosinophils had no effect on the Th2 response. Basophils did not take up inhaled antigen, present it to T cells, or express antigen presentation machinery, whereas a population of FceRI(+) DCs readily did. Inflammatory DCs were necessary and sufficient for induction of Th2 immunity and features of asthma, whereas basophils were not required. We favor a model whereby DCs initiate and basophils amplify Th2 immunity to HDM allergen.
Keywords
IN-VIVO DEPLETION, RESPONSES, EOSINOPHILIC AIRWAY INFLAMMATION, CD4(+) T-CELLS, TYPE-2 IMMUNITY, CUTTING EDGE, LYMPH-NODES, ADAPTIVE IMMUNITY, IL-4 PRODUCTION, STEADY-STATE

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MLA
Hammad, Hamida et al. “Inflammatory Dendritic Cells - Not Basophils - Are Necessary and Sufficient for Induction of Th2 Immunity to Inhaled House Dust Mite Allergen.” JOURNAL OF EXPERIMENTAL MEDICINE 207.10 (2010): 2097–2111. Print.
APA
Hammad, H., Plantinga, M., Deswarte, K., Pouliot, P., Willart, M., Kool, M., Muskens, F., et al. (2010). Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. JOURNAL OF EXPERIMENTAL MEDICINE, 207(10), 2097–2111.
Chicago author-date
Hammad, Hamida, Maud Plantinga, Kim Deswarte, Philippe Pouliot, Monique Willart, Mirjam Kool, Femke Muskens, and Bart Lambrecht. 2010. “Inflammatory Dendritic Cells - Not Basophils - Are Necessary and Sufficient for Induction of Th2 Immunity to Inhaled House Dust Mite Allergen.” Journal of Experimental Medicine 207 (10): 2097–2111.
Chicago author-date (all authors)
Hammad, Hamida, Maud Plantinga, Kim Deswarte, Philippe Pouliot, Monique Willart, Mirjam Kool, Femke Muskens, and Bart Lambrecht. 2010. “Inflammatory Dendritic Cells - Not Basophils - Are Necessary and Sufficient for Induction of Th2 Immunity to Inhaled House Dust Mite Allergen.” Journal of Experimental Medicine 207 (10): 2097–2111.
Vancouver
1.
Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart M, Kool M, et al. Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(10):2097–111.
IEEE
[1]
H. Hammad et al., “Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen,” JOURNAL OF EXPERIMENTAL MEDICINE, vol. 207, no. 10, pp. 2097–2111, 2010.
@article{1077765,
  abstract     = {It is unclear how Th2 immunity is induced in response to allergens like house dust mite (HDM). Here, we show that HDM inhalation leads to the TLR4/MyD88-dependent recruitment of IL-4 competent basophils and eosinophils, and of inflammatory DCs to the draining mediastinal nodes. Depletion of basophils only partially reduced Th2 immunity, and depletion of eosinophils had no effect on the Th2 response. Basophils did not take up inhaled antigen, present it to T cells, or express antigen presentation machinery, whereas a population of FceRI(+) DCs readily did. Inflammatory DCs were necessary and sufficient for induction of Th2 immunity and features of asthma, whereas basophils were not required. We favor a model whereby DCs initiate and basophils amplify Th2 immunity to HDM allergen.},
  author       = {Hammad, Hamida and Plantinga, Maud and Deswarte, Kim and Pouliot, Philippe and Willart, Monique and Kool, Mirjam and Muskens, Femke and Lambrecht, Bart},
  issn         = {0022-1007},
  journal      = {JOURNAL OF EXPERIMENTAL MEDICINE},
  keywords     = {IN-VIVO DEPLETION,RESPONSES,EOSINOPHILIC AIRWAY INFLAMMATION,CD4(+) T-CELLS,TYPE-2 IMMUNITY,CUTTING EDGE,LYMPH-NODES,ADAPTIVE IMMUNITY,IL-4 PRODUCTION,STEADY-STATE},
  language     = {eng},
  number       = {10},
  pages        = {2097--2111},
  title        = {Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen},
  url          = {http://dx.doi.org/10.1084/jem.20101563},
  volume       = {207},
  year         = {2010},
}

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