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Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

Hamida Hammad UGent, Maud Plantinga, Kim Deswarte UGent, Philippe Pouliot UGent, Monique Willart, Mirjam Kool UGent, Femke Muskens and Bart Lambrecht UGent (2010) JOURNAL OF EXPERIMENTAL MEDICINE. 207(10). p.2097-2111
abstract
It is unclear how Th2 immunity is induced in response to allergens like house dust mite (HDM). Here, we show that HDM inhalation leads to the TLR4/MyD88-dependent recruitment of IL-4 competent basophils and eosinophils, and of inflammatory DCs to the draining mediastinal nodes. Depletion of basophils only partially reduced Th2 immunity, and depletion of eosinophils had no effect on the Th2 response. Basophils did not take up inhaled antigen, present it to T cells, or express antigen presentation machinery, whereas a population of FceRI(+) DCs readily did. Inflammatory DCs were necessary and sufficient for induction of Th2 immunity and features of asthma, whereas basophils were not required. We favor a model whereby DCs initiate and basophils amplify Th2 immunity to HDM allergen.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
IN-VIVO DEPLETION, RESPONSES, EOSINOPHILIC AIRWAY INFLAMMATION, CD4(+) T-CELLS, TYPE-2 IMMUNITY, CUTTING EDGE, LYMPH-NODES, ADAPTIVE IMMUNITY, IL-4 PRODUCTION, STEADY-STATE
journal title
JOURNAL OF EXPERIMENTAL MEDICINE
J. Exp. Med.
volume
207
issue
10
pages
2097 - 2111
Web of Science type
Article
Web of Science id
000282649800008
JCR category
MEDICINE, RESEARCH & EXPERIMENTAL
JCR impact factor
14.776 (2010)
JCR rank
2/105 (2010)
JCR quartile
1 (2010)
ISSN
0022-1007
DOI
10.1084/jem.20101563
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1077765
handle
http://hdl.handle.net/1854/LU-1077765
date created
2010-11-22 14:30:32
date last changed
2016-12-19 15:46:41
@article{1077765,
  abstract     = {It is unclear how Th2 immunity is induced in response to allergens like house dust mite (HDM). Here, we show that HDM inhalation leads to the TLR4/MyD88-dependent recruitment of IL-4 competent basophils and eosinophils, and of inflammatory DCs to the draining mediastinal nodes. Depletion of basophils only partially reduced Th2 immunity, and depletion of eosinophils had no effect on the Th2 response. Basophils did not take up inhaled antigen, present it to T cells, or express antigen presentation machinery, whereas a population of FceRI(+) DCs readily did. Inflammatory DCs were necessary and sufficient for induction of Th2 immunity and features of asthma, whereas basophils were not required. We favor a model whereby DCs initiate and basophils amplify Th2 immunity to HDM allergen.},
  author       = {Hammad, Hamida and Plantinga, Maud and Deswarte, Kim and Pouliot, Philippe and Willart, Monique and Kool, Mirjam and Muskens, Femke and Lambrecht, Bart},
  issn         = {0022-1007},
  journal      = {JOURNAL OF EXPERIMENTAL MEDICINE},
  keyword      = {IN-VIVO DEPLETION,RESPONSES,EOSINOPHILIC AIRWAY INFLAMMATION,CD4(+) T-CELLS,TYPE-2 IMMUNITY,CUTTING EDGE,LYMPH-NODES,ADAPTIVE IMMUNITY,IL-4 PRODUCTION,STEADY-STATE},
  language     = {eng},
  number       = {10},
  pages        = {2097--2111},
  title        = {Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen},
  url          = {http://dx.doi.org/10.1084/jem.20101563},
  volume       = {207},
  year         = {2010},
}

Chicago
Hammad, Hamida, Maud Plantinga, Kim Deswarte, Philippe Pouliot, Monique Willart, Mirjam Kool, Femke Muskens, and Bart Lambrecht. 2010. “Inflammatory Dendritic Cells - Not Basophils - Are Necessary and Sufficient for Induction of Th2 Immunity to Inhaled House Dust Mite Allergen.” Journal of Experimental Medicine 207 (10): 2097–2111.
APA
Hammad, H., Plantinga, M., Deswarte, K., Pouliot, P., Willart, M., Kool, M., Muskens, F., et al. (2010). Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. JOURNAL OF EXPERIMENTAL MEDICINE, 207(10), 2097–2111.
Vancouver
1.
Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart M, Kool M, et al. Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(10):2097–111.
MLA
Hammad, Hamida, Maud Plantinga, Kim Deswarte, et al. “Inflammatory Dendritic Cells - Not Basophils - Are Necessary and Sufficient for Induction of Th2 Immunity to Inhaled House Dust Mite Allergen.” JOURNAL OF EXPERIMENTAL MEDICINE 207.10 (2010): 2097–2111. Print.