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Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives

Katrin Knop, Richard Hoogenboom UGent, Dagmar Fischer and Ulrich S Schubert (2010) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 49(36). p.6288-6308
abstract
Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer based drug delivery. The properties that account for the overwhelming use of PEG in biomedical applications are outlined in this Review. The first approved PEGylated products have already been on the market for 20 years. A vast amount of clinical experience has since been gained with this polymer—not only benefits, but possible side effects and complications have also been found. The areas that might need consideration and more intensive and careful examination can be divided into the following categories: hypersensitivity, unexpected changes in pharmacokinetic behavior, toxic side products, and an antagonism arising from the easy degradation of the polymer under mechanical stress as a result of its ether structure and its non-biodegradability, as well as the resulting possible accumulation in the body. These possible side effects will be discussed in this Review and alternative polymers will be evaluated.
Please use this url to cite or link to this publication:
author
organization
alternative title
PEG in drug delivery : pros and cons as well as potential alternatives
year
type
journalArticle (review)
publication status
published
subject
keyword
PEGalytion, drug delivery, biomedical materials, nanotechnology, poly(ethylene glycol), polymers, stealth effect, ACCELERATED BLOOD CLEARANCE, ELECTROLYTE LAVAGE SOLUTION, LOW-MOLECULAR-WEIGHT, AMPHIPHILIC DIBLOCK COPOLYMER, RING-OPENING POLYMERIZATION, ALLERGIC CONTACT-DERMATITIS, WATER-SOLUBLE POLYMERS, POLYETHYLENE-GLYCOL, IN-VIVO, HYPERBRANCHED POLYGLYCEROLS
journal title
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Angew Chem Int Ed
volume
49
issue
36
pages
6288 - 6308
Web of Science type
Review
Web of Science id
000281688700006
JCR category
CHEMISTRY, MULTIDISCIPLINARY
JCR impact factor
12.73 (2010)
JCR rank
5/142 (2010)
JCR quartile
1 (2010)
ISSN
1433-7851
DOI
10.1002/anie.200902672
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1072197
handle
http://hdl.handle.net/1854/LU-1072197
date created
2010-11-09 12:13:57
date last changed
2016-12-19 15:44:33
@article{1072197,
  abstract     = {Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer based drug delivery. The properties that account for the overwhelming use of PEG in biomedical applications are outlined in this Review. The first approved PEGylated products have already been on the market for 20 years. A vast amount of clinical experience has since been gained with this polymer---not only benefits, but possible side effects and complications have also been found. The areas that might need consideration and more intensive and careful examination can be divided into the following categories: hypersensitivity, unexpected changes in pharmacokinetic behavior, toxic side products, and an antagonism arising from the easy degradation of the polymer under mechanical stress as a result of its ether structure and its non-biodegradability, as well as the resulting possible accumulation in the body. These possible side effects will be discussed in this Review and alternative polymers will be evaluated.},
  author       = {Knop, Katrin and Hoogenboom, Richard and Fischer, Dagmar and Schubert, Ulrich S},
  issn         = {1433-7851},
  journal      = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},
  keyword      = {PEGalytion,drug delivery,biomedical materials,nanotechnology,poly(ethylene glycol),polymers,stealth effect,ACCELERATED BLOOD CLEARANCE,ELECTROLYTE LAVAGE SOLUTION,LOW-MOLECULAR-WEIGHT,AMPHIPHILIC DIBLOCK COPOLYMER,RING-OPENING POLYMERIZATION,ALLERGIC CONTACT-DERMATITIS,WATER-SOLUBLE POLYMERS,POLYETHYLENE-GLYCOL,IN-VIVO,HYPERBRANCHED POLYGLYCEROLS},
  language     = {eng},
  number       = {36},
  pages        = {6288--6308},
  title        = {Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives},
  url          = {http://dx.doi.org/10.1002/anie.200902672},
  volume       = {49},
  year         = {2010},
}

Chicago
Knop, Katrin, Richard Hoogenboom, Dagmar Fischer, and Ulrich S Schubert. 2010. “Poly(ethylene Glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives.” Angewandte Chemie-international Edition 49 (36): 6288–6308.
APA
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010). Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 49(36), 6288–6308.
Vancouver
1.
Knop K, Hoogenboom R, Fischer D, Schubert US. Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2010;49(36):6288–308.
MLA
Knop, Katrin, Richard Hoogenboom, Dagmar Fischer, et al. “Poly(ethylene Glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives.” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 49.36 (2010): 6288–6308. Print.