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Oocyte activation, phospholipase C zeta and human infertility

(2010) HUMAN REPRODUCTION UPDATE. 16(6). p.690-703
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Abstract
Mammalian oocytes are activated by intracellular calcium (Ca2+) oscillations following gamete fusion. Recent evidence implicates a sperm-specific phospholipase C zeta, PLC zeta, which is introduced into the oocyte following membrane fusion, as the responsible factor. This review summarizes the current understanding of human oocyte activation failure and describes recent discoveries linking certain cases of male infertility with defects in PLC zeta expression and activity. How these latest findings may influence future diagnosis and treatment options are also discussed. Systematic literature searches were performed using PubMed, ISI-Web of Knowledge and The Cochrane Library. We also scrutinized material from the United Nations and World Health Organization databases (UNWHO) and the Human Fertilization and Embryology Authority (HFEA). Although ICSI results in average fertilization rates of 70%, complete or virtually complete fertilization failure still occurs in 1-5% of ICSI cycles. While oocyte activation failure can, in some cases, be overcome by artificial oocyte activators such as calcium ionophores, a more physiological oocyte activation agent might release Ca2+ within the oocyte in a more efficient and controlled manner. As PLC zeta is now widely considered to be the physiological agent responsible for activating mammalian oocytes, it represents both a novel diagnostic biomarker of oocyte activation capability and a possible mode of treatment for certain types of male infertility.
Keywords
PLC-ZETA, EF-HAND DOMAINS, FERTILIZED MOUSE EGGS, CELL NUCLEAR TRANSFER, MAMMALIAN EGG ACTIVATION, HUMAN PARTHENOGENETIC BLASTOCYSTS, ASSISTED REPRODUCTIVE TECHNOLOGY, ROUND-HEADED SPERMATOZOA, INTRACYTOPLASMIC SPERM INJECTION, TRIGGERS CA2+ OSCILLATIONS, phospholipase C zeta, sperm, oocyte activation, human infertility, calcium

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Citation

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Chicago
Kashir, J, Björn Heindryckx, C Jones, Petra De Sutter, J Parrington, and K Coward. 2010. “Oocyte Activation, Phospholipase C Zeta and Human Infertility.” Human Reproduction Update 16 (6): 690–703.
APA
Kashir, J, Heindryckx, B., Jones, C., De Sutter, P., Parrington, J., & Coward, K. (2010). Oocyte activation, phospholipase C zeta and human infertility. HUMAN REPRODUCTION UPDATE, 16(6), 690–703.
Vancouver
1.
Kashir J, Heindryckx B, Jones C, De Sutter P, Parrington J, Coward K. Oocyte activation, phospholipase C zeta and human infertility. HUMAN REPRODUCTION UPDATE. 2010;16(6):690–703.
MLA
Kashir, J, Björn Heindryckx, C Jones, et al. “Oocyte Activation, Phospholipase C Zeta and Human Infertility.” HUMAN REPRODUCTION UPDATE 16.6 (2010): 690–703. Print.
@article{1071194,
  abstract     = {Mammalian oocytes are activated by intracellular calcium (Ca2+) oscillations following gamete fusion. Recent evidence implicates a sperm-specific phospholipase C zeta, PLC zeta, which is introduced into the oocyte following membrane fusion, as the responsible factor. This review summarizes the current understanding of human oocyte activation failure and describes recent discoveries linking certain cases of male infertility with defects in PLC zeta expression and activity. How these latest findings may influence future diagnosis and treatment options are also discussed.
Systematic literature searches were performed using PubMed, ISI-Web of Knowledge and The Cochrane Library. We also scrutinized material from the United Nations and World Health Organization databases (UNWHO) and the Human Fertilization and Embryology Authority (HFEA).
Although ICSI results in average fertilization rates of 70\%, complete or virtually complete fertilization failure still occurs in 1-5\% of ICSI cycles. While oocyte activation failure can, in some cases, be overcome by artificial oocyte activators such as calcium ionophores, a more physiological oocyte activation agent might release Ca2+ within the oocyte in a more efficient and controlled manner. As PLC zeta is now widely considered to be the physiological agent responsible for activating mammalian oocytes, it represents both a novel diagnostic biomarker of oocyte activation capability and a possible mode of treatment for certain types of male infertility.},
  author       = {Kashir, J and Heindryckx, Bj{\"o}rn and Jones, C and De Sutter, Petra and Parrington, J and Coward, K},
  issn         = {1355-4786},
  journal      = {HUMAN REPRODUCTION UPDATE},
  keyword      = {PLC-ZETA,EF-HAND DOMAINS,FERTILIZED MOUSE EGGS,CELL NUCLEAR TRANSFER,MAMMALIAN EGG ACTIVATION,HUMAN PARTHENOGENETIC BLASTOCYSTS,ASSISTED REPRODUCTIVE TECHNOLOGY,ROUND-HEADED SPERMATOZOA,INTRACYTOPLASMIC SPERM INJECTION,TRIGGERS CA2+ OSCILLATIONS,phospholipase C zeta,sperm,oocyte activation,human infertility,calcium},
  language     = {eng},
  number       = {6},
  pages        = {690--703},
  title        = {Oocyte activation, phospholipase C zeta and human infertility},
  url          = {http://dx.doi.org/10.1093/humupd/dmq018},
  volume       = {16},
  year         = {2010},
}

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