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Oocyte activation, phospholipase C zeta and human infertility

J Kashir, Björn Heindryckx UGent, C Jones, Petra De Sutter UGent, J Parrington and K Coward (2010) HUMAN REPRODUCTION UPDATE. 16(6). p.690-703
abstract
Mammalian oocytes are activated by intracellular calcium (Ca2+) oscillations following gamete fusion. Recent evidence implicates a sperm-specific phospholipase C zeta, PLC zeta, which is introduced into the oocyte following membrane fusion, as the responsible factor. This review summarizes the current understanding of human oocyte activation failure and describes recent discoveries linking certain cases of male infertility with defects in PLC zeta expression and activity. How these latest findings may influence future diagnosis and treatment options are also discussed. Systematic literature searches were performed using PubMed, ISI-Web of Knowledge and The Cochrane Library. We also scrutinized material from the United Nations and World Health Organization databases (UNWHO) and the Human Fertilization and Embryology Authority (HFEA). Although ICSI results in average fertilization rates of 70%, complete or virtually complete fertilization failure still occurs in 1-5% of ICSI cycles. While oocyte activation failure can, in some cases, be overcome by artificial oocyte activators such as calcium ionophores, a more physiological oocyte activation agent might release Ca2+ within the oocyte in a more efficient and controlled manner. As PLC zeta is now widely considered to be the physiological agent responsible for activating mammalian oocytes, it represents both a novel diagnostic biomarker of oocyte activation capability and a possible mode of treatment for certain types of male infertility.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PLC-ZETA, EF-HAND DOMAINS, FERTILIZED MOUSE EGGS, CELL NUCLEAR TRANSFER, MAMMALIAN EGG ACTIVATION, HUMAN PARTHENOGENETIC BLASTOCYSTS, ASSISTED REPRODUCTIVE TECHNOLOGY, ROUND-HEADED SPERMATOZOA, INTRACYTOPLASMIC SPERM INJECTION, TRIGGERS CA2+ OSCILLATIONS, phospholipase C zeta, sperm, oocyte activation, human infertility, calcium
journal title
HUMAN REPRODUCTION UPDATE
Hum. Reprod. Update
volume
16
issue
6
pages
690 - 703
Web of Science type
Article
Web of Science id
000283123200011
JCR category
OBSTETRICS & GYNECOLOGY
JCR impact factor
8.755 (2010)
JCR rank
1/75 (2010)
JCR quartile
1 (2010)
ISSN
1355-4786
DOI
10.1093/humupd/dmq018
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1071194
handle
http://hdl.handle.net/1854/LU-1071194
date created
2010-11-08 08:54:30
date last changed
2016-12-19 15:46:30
@article{1071194,
  abstract     = {Mammalian oocytes are activated by intracellular calcium (Ca2+) oscillations following gamete fusion. Recent evidence implicates a sperm-specific phospholipase C zeta, PLC zeta, which is introduced into the oocyte following membrane fusion, as the responsible factor. This review summarizes the current understanding of human oocyte activation failure and describes recent discoveries linking certain cases of male infertility with defects in PLC zeta expression and activity. How these latest findings may influence future diagnosis and treatment options are also discussed.
Systematic literature searches were performed using PubMed, ISI-Web of Knowledge and The Cochrane Library. We also scrutinized material from the United Nations and World Health Organization databases (UNWHO) and the Human Fertilization and Embryology Authority (HFEA).
Although ICSI results in average fertilization rates of 70\%, complete or virtually complete fertilization failure still occurs in 1-5\% of ICSI cycles. While oocyte activation failure can, in some cases, be overcome by artificial oocyte activators such as calcium ionophores, a more physiological oocyte activation agent might release Ca2+ within the oocyte in a more efficient and controlled manner. As PLC zeta is now widely considered to be the physiological agent responsible for activating mammalian oocytes, it represents both a novel diagnostic biomarker of oocyte activation capability and a possible mode of treatment for certain types of male infertility.},
  author       = {Kashir, J and Heindryckx, Bj{\"o}rn and Jones, C and De Sutter, Petra and Parrington, J and Coward, K},
  issn         = {1355-4786},
  journal      = {HUMAN REPRODUCTION UPDATE},
  keyword      = {PLC-ZETA,EF-HAND DOMAINS,FERTILIZED MOUSE EGGS,CELL NUCLEAR TRANSFER,MAMMALIAN EGG ACTIVATION,HUMAN PARTHENOGENETIC BLASTOCYSTS,ASSISTED REPRODUCTIVE TECHNOLOGY,ROUND-HEADED SPERMATOZOA,INTRACYTOPLASMIC SPERM INJECTION,TRIGGERS CA2+ OSCILLATIONS,phospholipase C zeta,sperm,oocyte activation,human infertility,calcium},
  language     = {eng},
  number       = {6},
  pages        = {690--703},
  title        = {Oocyte activation, phospholipase C zeta and human infertility},
  url          = {http://dx.doi.org/10.1093/humupd/dmq018},
  volume       = {16},
  year         = {2010},
}

Chicago
Kashir, J, Björn Heindryckx, C Jones, Petra De Sutter, J Parrington, and K Coward. 2010. “Oocyte Activation, Phospholipase C Zeta and Human Infertility.” Human Reproduction Update 16 (6): 690–703.
APA
Kashir, J, Heindryckx, B., Jones, C., De Sutter, P., Parrington, J., & Coward, K. (2010). Oocyte activation, phospholipase C zeta and human infertility. HUMAN REPRODUCTION UPDATE, 16(6), 690–703.
Vancouver
1.
Kashir J, Heindryckx B, Jones C, De Sutter P, Parrington J, Coward K. Oocyte activation, phospholipase C zeta and human infertility. HUMAN REPRODUCTION UPDATE. 2010;16(6):690–703.
MLA
Kashir, J, Björn Heindryckx, C Jones, et al. “Oocyte Activation, Phospholipase C Zeta and Human Infertility.” HUMAN REPRODUCTION UPDATE 16.6 (2010): 690–703. Print.