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Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease

(2010) KIDNEY INTERNATIONAL. 77(6). p.550-556
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Abstract
Chronic inflammation associated with chronic kidney disease predicts all-cause and cardiovascular mortality in hemodialysis patients. Here we sought to evaluate the association between plasma levels of the inflammatory mediator interleukin-6 (IL-6) and mortality and aortic calcification/stiffness in 125 patients at different stages (2-5D) of chronic kidney disease. Using multivariate linear regression, we found that plasma IL-6 was independently associated with C-reactive protein, albumin and the stage of chronic kidney disease, but not the aortic calcification score or pulse wave velocity. During follow-up studies (median of 829 days), 38 patients died, 22 from cardiovascular events. Plasma IL-6 significantly predicted overall and cardiovascular mortality; this association persisted after multiple adjustments or restricting the analysis to pre-dialysis patients. Moreover, IL-6 was a significantly better predictor of mortality than C-reactive protein, albumin or tumor necrosis factor-a. Hence, plasma IL-6 independently predicted overall and cardiovascular mortality in patients at different stages of chronic kidney disease; however, whether lowering plasma IL-6 will affect the outcome of chronic kidney disease will require more direct evaluation.
Keywords
vascular calcification, CHRONIC-RENAL-FAILURE, cardiovascular disease, chronic kidney disease, inflammation, mortality, C-REACTIVE PROTEIN, PRO-INFLAMMATORY CYTOKINES, CARDIOVASCULAR MORTALITY, ANGIOTENSIN-II, ALL-CAUSE, TNF-ALPHA, CARDIAC-DISEASE, MYOCARDIAL-INFARCTION, SERUM CREATININE

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Chicago
Barreto, Daniela V, Fellype C Barreto, Sophie Liabeuf, Mohammed Temmar, Horst-Dieter Lemke, Christophe Tribouilloy, Gabriel Choukroun, Raymond Vanholder, and Ziad A Massy. 2010. “Plasma Interleukin-6 Is Independently Associated with Mortality in Both Hemodialysis and Pre-dialysis Patients with Chronic Kidney Disease.” Kidney International 77 (6): 550–556.
APA
Barreto, D. V., Barreto, F. C., Liabeuf, S., Temmar, M., Lemke, H.-D., Tribouilloy, C., Choukroun, G., et al. (2010). Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease. KIDNEY INTERNATIONAL, 77(6), 550–556.
Vancouver
1.
Barreto DV, Barreto FC, Liabeuf S, Temmar M, Lemke H-D, Tribouilloy C, et al. Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease. KIDNEY INTERNATIONAL. 2010;77(6):550–6.
MLA
Barreto, Daniela V, Fellype C Barreto, Sophie Liabeuf, et al. “Plasma Interleukin-6 Is Independently Associated with Mortality in Both Hemodialysis and Pre-dialysis Patients with Chronic Kidney Disease.” KIDNEY INTERNATIONAL 77.6 (2010): 550–556. Print.
@article{1068979,
  abstract     = {Chronic inflammation associated with chronic kidney disease predicts all-cause and cardiovascular mortality in hemodialysis patients. Here we sought to evaluate the association between plasma levels of the inflammatory mediator interleukin-6 (IL-6) and mortality and aortic calcification/stiffness in 125 patients at different stages (2-5D) of chronic kidney disease. Using multivariate linear regression, we found that plasma IL-6 was independently associated with C-reactive protein, albumin and the stage of chronic kidney disease, but not the aortic calcification score or pulse wave velocity. During follow-up studies (median of 829 days), 38 patients died, 22 from cardiovascular events. Plasma IL-6 significantly predicted overall and cardiovascular mortality; this association persisted after multiple adjustments or restricting the analysis to pre-dialysis patients. Moreover, IL-6 was a significantly better predictor of mortality than C-reactive protein, albumin or tumor necrosis factor-a. Hence, plasma IL-6 independently predicted overall and cardiovascular mortality in patients at different stages of chronic kidney disease; however, whether lowering plasma IL-6 will affect the outcome of chronic kidney disease will require more direct evaluation.},
  author       = {Barreto, Daniela V and Barreto, Fellype C and Liabeuf, Sophie and Temmar, Mohammed and Lemke, Horst-Dieter and Tribouilloy, Christophe and Choukroun, Gabriel and Vanholder, Raymond and Massy, Ziad A},
  issn         = {0085-2538},
  journal      = {KIDNEY INTERNATIONAL},
  keyword      = {vascular calcification,CHRONIC-RENAL-FAILURE,cardiovascular disease,chronic kidney disease,inflammation,mortality,C-REACTIVE PROTEIN,PRO-INFLAMMATORY CYTOKINES,CARDIOVASCULAR MORTALITY,ANGIOTENSIN-II,ALL-CAUSE,TNF-ALPHA,CARDIAC-DISEASE,MYOCARDIAL-INFARCTION,SERUM CREATININE},
  language     = {eng},
  number       = {6},
  pages        = {550--556},
  title        = {Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease},
  url          = {http://dx.doi.org/10.1038/ki.2009.503},
  volume       = {77},
  year         = {2010},
}

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