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Fanconi syndrome in lymphoma patients: report of the first case series

Jill Vanmassenhove, Marion Sallée, Philippe Guilpain, Raymond Vanholder UGent, ALEXANDRA DE POTTER UGent, Louis Libbrecht UGent, Felipe Suarez, Olivier Hermine and Fadi Fakhouri (2010) NEPHROLOGY DIALYSIS TRANSPLANTATION. 25(8). p.2516-2520
abstract
Background. Fanconi syndrome (FS) is a generalized transport defect in the proximal renal tubule leading to renal losses of phosphate, calcium, uric acid, bicarbonates as well as glucose, amino acids and other organic compounds. It is caused by inherited or acquired disorders including low mass or high mass multiple myeloma. Objectives. To report the first case series of patients with lymphoma and FS. Design, setting, participants, and measurements. Patients with lymphoma and FS were identified in the nephrology department of two teaching hospitals in Paris, France and Ghent, Belgium. FS was defined by the presence of at least three out of the four following criteria: hypophosphataemia, metabolic acidosis, normoglycaemic glucosuria and hypokalaemia. Patients files were reviewed and relevant data were collected. Results. Eight patients with lymphoma and FS were identified. In six patients, the lymphoma was of the acute T cell leukaemia/lymphoma (ATLL) type, related to human T cell lymphotropic virus 1 (HTLV1) infection. In all patients, FS was severe requiring supplementation. A kidney biopsy performed in a patient with post-transplantation primary renal lymphoma disclosed intense proximal tubule infiltration by lymphomatous cells. In one patient with ATLL, FS features regressed following the successful treatment of lymphoma. Conclusion. Patients with lymphoma require careful monitoring for features of FS; lymphoma should also be added to the spectrum of disorders associated to FS. Propective studies are needed to ascertain the implication of HTLV1 in the genesis of FS.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ACUTE-RENAL-FAILURE, NEPHROGENIC DIABETES-INSIPIDUS, VIRUS TYPE-1, LYMPHOPLASMACYTIC LYMPHOMA, INFECTION, DISEASE, NEPHROTIC SYNDROME, TRANSMISSION, Fanconi syndrome, PROVIRUS, T-CELL LEUKEMIA, HTLV-1, lymphoma
journal title
NEPHROLOGY DIALYSIS TRANSPLANTATION
Nephrol. Dial. Transplant.
volume
25
issue
8
pages
2516 - 2520
Web of Science type
Article
Web of Science id
000281483300021
JCR category
UROLOGY & NEPHROLOGY
JCR impact factor
3.564 (2010)
JCR rank
12/68 (2010)
JCR quartile
1 (2010)
ISSN
0931-0509
DOI
10.1093/ndt/gfq045
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1068821
handle
http://hdl.handle.net/1854/LU-1068821
date created
2010-11-03 09:58:59
date last changed
2012-03-22 15:35:47
@article{1068821,
  abstract     = {Background. Fanconi syndrome (FS) is a generalized transport defect in the proximal renal tubule leading to renal losses of phosphate, calcium, uric acid, bicarbonates as well as glucose, amino acids and other organic compounds. It is caused by inherited or acquired disorders including low mass or high mass multiple myeloma.
Objectives. To report the first case series of patients with lymphoma and FS.
Design, setting, participants, and measurements. Patients with lymphoma and FS were identified in the nephrology department of two teaching hospitals in Paris, France and Ghent, Belgium. FS was defined by the presence of at least three out of the four following criteria: hypophosphataemia, metabolic acidosis, normoglycaemic glucosuria and hypokalaemia. Patients files were reviewed and relevant data were collected.
Results. Eight patients with lymphoma and FS were identified. In six patients, the lymphoma was of the acute T cell leukaemia/lymphoma (ATLL) type, related to human T cell lymphotropic virus 1 (HTLV1) infection. In all patients, FS was severe requiring supplementation. A kidney biopsy performed in a patient with post-transplantation primary renal lymphoma disclosed intense proximal tubule infiltration by lymphomatous cells. In one patient with ATLL, FS features regressed following the successful treatment of lymphoma.
Conclusion. Patients with lymphoma require careful monitoring for features of FS; lymphoma should also be added to the spectrum of disorders associated to FS. Propective studies are needed to ascertain the implication of HTLV1 in the genesis of FS.},
  author       = {Vanmassenhove, Jill and Sall{\'e}e, Marion and Guilpain, Philippe and Vanholder, Raymond and DE POTTER, ALEXANDRA and Libbrecht, Louis and Suarez, Felipe and Hermine, Olivier and Fakhouri, Fadi},
  issn         = {0931-0509},
  journal      = {NEPHROLOGY DIALYSIS TRANSPLANTATION},
  keyword      = {ACUTE-RENAL-FAILURE,NEPHROGENIC DIABETES-INSIPIDUS,VIRUS TYPE-1,LYMPHOPLASMACYTIC LYMPHOMA,INFECTION,DISEASE,NEPHROTIC SYNDROME,TRANSMISSION,Fanconi syndrome,PROVIRUS,T-CELL LEUKEMIA,HTLV-1,lymphoma},
  language     = {eng},
  number       = {8},
  pages        = {2516--2520},
  title        = {Fanconi syndrome in lymphoma patients: report of the first case series},
  url          = {http://dx.doi.org/10.1093/ndt/gfq045},
  volume       = {25},
  year         = {2010},
}

Chicago
Vanmassenhove, Jill, Marion Sallée, Philippe Guilpain, Raymond Vanholder, ALEXANDRA DE POTTER, Louis Libbrecht, Felipe Suarez, Olivier Hermine, and Fadi Fakhouri. 2010. “Fanconi Syndrome in Lymphoma Patients: Report of the First Case Series.” Nephrology Dialysis Transplantation 25 (8): 2516–2520.
APA
Vanmassenhove, J., Sallée, M., Guilpain, P., Vanholder, R., DE POTTER, A., Libbrecht, L., Suarez, F., et al. (2010). Fanconi syndrome in lymphoma patients: report of the first case series. NEPHROLOGY DIALYSIS TRANSPLANTATION, 25(8), 2516–2520.
Vancouver
1.
Vanmassenhove J, Sallée M, Guilpain P, Vanholder R, DE POTTER A, Libbrecht L, et al. Fanconi syndrome in lymphoma patients: report of the first case series. NEPHROLOGY DIALYSIS TRANSPLANTATION. 2010;25(8):2516–20.
MLA
Vanmassenhove, Jill, Marion Sallée, Philippe Guilpain, et al. “Fanconi Syndrome in Lymphoma Patients: Report of the First Case Series.” NEPHROLOGY DIALYSIS TRANSPLANTATION 25.8 (2010): 2516–2520. Print.