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Fanconi syndrome in lymphoma patients: report of the first case series

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Abstract
Background. Fanconi syndrome (FS) is a generalized transport defect in the proximal renal tubule leading to renal losses of phosphate, calcium, uric acid, bicarbonates as well as glucose, amino acids and other organic compounds. It is caused by inherited or acquired disorders including low mass or high mass multiple myeloma. Objectives. To report the first case series of patients with lymphoma and FS. Design, setting, participants, and measurements. Patients with lymphoma and FS were identified in the nephrology department of two teaching hospitals in Paris, France and Ghent, Belgium. FS was defined by the presence of at least three out of the four following criteria: hypophosphataemia, metabolic acidosis, normoglycaemic glucosuria and hypokalaemia. Patients files were reviewed and relevant data were collected. Results. Eight patients with lymphoma and FS were identified. In six patients, the lymphoma was of the acute T cell leukaemia/lymphoma (ATLL) type, related to human T cell lymphotropic virus 1 (HTLV1) infection. In all patients, FS was severe requiring supplementation. A kidney biopsy performed in a patient with post-transplantation primary renal lymphoma disclosed intense proximal tubule infiltration by lymphomatous cells. In one patient with ATLL, FS features regressed following the successful treatment of lymphoma. Conclusion. Patients with lymphoma require careful monitoring for features of FS; lymphoma should also be added to the spectrum of disorders associated to FS. Propective studies are needed to ascertain the implication of HTLV1 in the genesis of FS.
Keywords
ACUTE-RENAL-FAILURE, NEPHROGENIC DIABETES-INSIPIDUS, VIRUS TYPE-1, LYMPHOPLASMACYTIC LYMPHOMA, INFECTION, DISEASE, NEPHROTIC SYNDROME, TRANSMISSION, Fanconi syndrome, PROVIRUS, T-CELL LEUKEMIA, HTLV-1, lymphoma

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Chicago
Vanmassenhove, Jill, Marion Sallée, Philippe Guilpain, Raymond Vanholder, ALEXANDRA DE POTTER, Louis Libbrecht, Felipe Suarez, Olivier Hermine, and Fadi Fakhouri. 2010. “Fanconi Syndrome in Lymphoma Patients: Report of the First Case Series.” Nephrology Dialysis Transplantation 25 (8): 2516–2520.
APA
Vanmassenhove, J., Sallée, M., Guilpain, P., Vanholder, R., DE POTTER, A., Libbrecht, L., Suarez, F., et al. (2010). Fanconi syndrome in lymphoma patients: report of the first case series. NEPHROLOGY DIALYSIS TRANSPLANTATION, 25(8), 2516–2520.
Vancouver
1.
Vanmassenhove J, Sallée M, Guilpain P, Vanholder R, DE POTTER A, Libbrecht L, et al. Fanconi syndrome in lymphoma patients: report of the first case series. NEPHROLOGY DIALYSIS TRANSPLANTATION. 2010;25(8):2516–20.
MLA
Vanmassenhove, Jill, Marion Sallée, Philippe Guilpain, et al. “Fanconi Syndrome in Lymphoma Patients: Report of the First Case Series.” NEPHROLOGY DIALYSIS TRANSPLANTATION 25.8 (2010): 2516–2520. Print.
@article{1068821,
  abstract     = {Background. Fanconi syndrome (FS) is a generalized transport defect in the proximal renal tubule leading to renal losses of phosphate, calcium, uric acid, bicarbonates as well as glucose, amino acids and other organic compounds. It is caused by inherited or acquired disorders including low mass or high mass multiple myeloma.
Objectives. To report the first case series of patients with lymphoma and FS.
Design, setting, participants, and measurements. Patients with lymphoma and FS were identified in the nephrology department of two teaching hospitals in Paris, France and Ghent, Belgium. FS was defined by the presence of at least three out of the four following criteria: hypophosphataemia, metabolic acidosis, normoglycaemic glucosuria and hypokalaemia. Patients files were reviewed and relevant data were collected.
Results. Eight patients with lymphoma and FS were identified. In six patients, the lymphoma was of the acute T cell leukaemia/lymphoma (ATLL) type, related to human T cell lymphotropic virus 1 (HTLV1) infection. In all patients, FS was severe requiring supplementation. A kidney biopsy performed in a patient with post-transplantation primary renal lymphoma disclosed intense proximal tubule infiltration by lymphomatous cells. In one patient with ATLL, FS features regressed following the successful treatment of lymphoma.
Conclusion. Patients with lymphoma require careful monitoring for features of FS; lymphoma should also be added to the spectrum of disorders associated to FS. Propective studies are needed to ascertain the implication of HTLV1 in the genesis of FS.},
  author       = {Vanmassenhove, Jill and Sall{\'e}e, Marion and Guilpain, Philippe and Vanholder, Raymond and DE POTTER, ALEXANDRA and Libbrecht, Louis and Suarez, Felipe and Hermine, Olivier and Fakhouri, Fadi},
  issn         = {0931-0509},
  journal      = {NEPHROLOGY DIALYSIS TRANSPLANTATION},
  keyword      = {ACUTE-RENAL-FAILURE,NEPHROGENIC DIABETES-INSIPIDUS,VIRUS TYPE-1,LYMPHOPLASMACYTIC LYMPHOMA,INFECTION,DISEASE,NEPHROTIC SYNDROME,TRANSMISSION,Fanconi syndrome,PROVIRUS,T-CELL LEUKEMIA,HTLV-1,lymphoma},
  language     = {eng},
  number       = {8},
  pages        = {2516--2520},
  title        = {Fanconi syndrome in lymphoma patients: report of the first case series},
  url          = {http://dx.doi.org/10.1093/ndt/gfq045},
  volume       = {25},
  year         = {2010},
}

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