Ghent University Academic Bibliography

Advanced

Neurovascular dishabituation in patients with migraine without aura

Benedicte Descamps UGent, Pieter Vandemaele UGent, Harmen Reyngoudt UGent, Karel Deblaere UGent, Luc Leybaert UGent, Koen Paemeleire UGent and Eric Achten UGent (2010) JOURNAL OF HEADACHE AND PAIN. 11(suppl. 1). p.S24-S25
abstract
Background: Absence of habituation during VEP measurements has extensively been studied in patients with migraine [1,2]. It is unclear whether this electrical phenomenon is accompanied by hemodynamic anomalies. In healthy controls, EP-habituation is well-known and hemodynamic refractory effects are observed in the net BOLDresponses to repetitive visual stimuli [3], i.e. a decreased amplitude and increased latency in time-to-peak for interstimulus intervals less than 6 seconds. Interictal hemodynamic differences between patients with migraine without aura and healthy controls have not been investigated. Methods: In this study, we measure interictal hemodynamic responses with functional magnetic resonance imaging in patients with migraine without aura and compare them with responses from healthy controls. Net responses to paired visual stimuli with varying interstimulus intervals are calculated. Several characterizing parameters of the responses are quantified. ANOVA and post-hoc Bonferroni tests are used for statistical analysis (significance level = 0.05). Results and discussion: Refractory effects are not observed in patients. There is no amplitude decrease, nor increased latency in time-to-peak in patients, not even for the shortest interstimulus interval, whereas in controls, refractory effects are found for all parameters of the net responses for an interstimulus interval of 1 second (amplitude and time-to-peak: p<0.001; width: p<0.01). The nonlinearities (i.e. differences in measured vs. expected responses) fade away with longer interstimulus intervals and have disappeared at the interstimulus interval of 6 seconds. The absence of refractory effects in patients with migraine without aura reflects the neurovascular correlate of the absence of habituation in this patient group. Multi-modal data acquisition (VEP/fMRI) or follow-up of patients taking prophylactic drugs may be subject to further research. References [1] Schoenen J. et al. (1995). Eur J Neurol 2(2): 115–22; [2] A ´ fra J. et al. (1998). Brain 121(2): 233–41; [3] Huettel S. A. and McCarthy G. (2000). NeuroImage 11(5): 547–55.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
fMRI, hemodynamics, migraine without aura, pathophysiology
in
JOURNAL OF HEADACHE AND PAIN
J. Headache Pain
volume
11
issue
suppl. 1
article_number
abstract 134
pages
S24 - S25
conference name
2nd European Headache and Migraine Trust international congress (EHMTIC 2010)
conference location
Nice, France
conference start
2010-10-28
conference end
2010-10-31
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.015 (2010)
JCR rank
91/185 (2010)
JCR quartile
2 (2010)
ISSN
1129-2369
language
English
UGent publication?
yes
classification
C3
id
1068619
handle
http://hdl.handle.net/1854/LU-1068619
alternative location
http://www.springerlink.com/content/1129-2369/11/s1/
date created
2010-11-02 11:54:07
date last changed
2010-11-26 08:56:35
@inproceedings{1068619,
  abstract     = {Background: Absence of habituation during VEP measurements has extensively been studied in patients with migraine [1,2]. It is unclear whether this electrical phenomenon is accompanied by hemodynamic anomalies. In healthy controls, EP-habituation is well-known and hemodynamic refractory effects are observed in the net BOLDresponses to repetitive visual stimuli [3], i.e. a decreased amplitude and increased latency in time-to-peak for interstimulus intervals less than 6 seconds. Interictal hemodynamic differences between patients with migraine without aura and healthy controls have not been investigated.
Methods: In this study, we measure interictal hemodynamic responses with functional magnetic resonance imaging in patients with migraine without aura and compare them with responses from healthy controls. Net responses to paired visual stimuli with varying interstimulus intervals are calculated. Several characterizing parameters of the responses are quantified. ANOVA and post-hoc Bonferroni tests are used for statistical analysis (significance level = 0.05).
Results and discussion: Refractory effects are not observed in patients. There is no amplitude decrease, nor increased latency in time-to-peak in patients, not even for the shortest interstimulus interval, whereas in controls, refractory effects are found for all parameters of the net responses for an interstimulus interval of 1 second (amplitude and time-to-peak: p{\textlangle}0.001; width: p{\textlangle}0.01). The nonlinearities (i.e. differences in measured vs. expected responses) fade away with longer interstimulus intervals and have disappeared at the interstimulus interval of 6 seconds. The absence of refractory effects in patients with migraine without aura reflects the neurovascular correlate of the absence of habituation in this patient group. Multi-modal data acquisition (VEP/fMRI) or follow-up of patients taking prophylactic drugs may be subject to further research.
References
[1] Schoenen J. et al. (1995). Eur J Neurol 2(2): 115--22;
[2] A {\textasciiacute} fra J. et al. (1998). Brain 121(2): 233--41;
[3] Huettel S. A. and McCarthy G. (2000). NeuroImage 11(5):
547--55.},
  articleno    = {abstract 134},
  author       = {Descamps, Benedicte and Vandemaele, Pieter and Reyngoudt, Harmen and Deblaere, Karel and Leybaert, Luc and Paemeleire, Koen and Achten, Eric},
  booktitle    = {JOURNAL OF HEADACHE AND PAIN},
  issn         = {1129-2369},
  keyword      = {fMRI,hemodynamics,migraine without aura,pathophysiology},
  language     = {eng},
  location     = {Nice, France},
  number       = {suppl. 1},
  pages        = {abstract 134:S24--abstract 134:S25},
  title        = {Neurovascular dishabituation in patients with migraine without aura},
  url          = {http://www.springerlink.com/content/1129-2369/11/s1/},
  volume       = {11},
  year         = {2010},
}

Chicago
Descamps, Benedicte, Pieter Vandemaele, Harmen Reyngoudt, Karel Deblaere, Luc Leybaert, Koen Paemeleire, and Eric Achten. 2010. “Neurovascular Dishabituation in Patients with Migraine Without Aura.” In Journal of Headache and Pain, 11:S24–S25.
APA
Descamps, B., Vandemaele, P., Reyngoudt, H., Deblaere, K., Leybaert, L., Paemeleire, K., & Achten, E. (2010). Neurovascular dishabituation in patients with migraine without aura. JOURNAL OF HEADACHE AND PAIN (Vol. 11, pp. S24–S25). Presented at the 2nd European Headache and Migraine Trust international congress (EHMTIC 2010).
Vancouver
1.
Descamps B, Vandemaele P, Reyngoudt H, Deblaere K, Leybaert L, Paemeleire K, et al. Neurovascular dishabituation in patients with migraine without aura. JOURNAL OF HEADACHE AND PAIN. 2010. p. S24–S25.
MLA
Descamps, Benedicte, Pieter Vandemaele, Harmen Reyngoudt, et al. “Neurovascular Dishabituation in Patients with Migraine Without Aura.” Journal of Headache and Pain. Vol. 11. 2010. S24–S25. Print.