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More antisaccade errors in migraine patients

Melissa Cambron UGent, Shari Anseeuw UGent, Koen Paemeleire UGent and Luc Crevits UGent (2010) JOURNAL OF HEADACHE AND PAIN. 11(suppl. 1). p.S52-S52
abstract
Aim Recent voxel-based morphometry studies in migraine patients have shown subtle but significant reductions in grey matter in cortical areas involved in pain processing (including the prefrontal and cingulate cortices), which are related to migraine frequency. (1-5) We hypothesized these changes would be reflected in the control of saccadic eye movements. Methods Saccades were recorded by infrared-oculography. Three tasks were performed: a prosaccade gap and overlap task during which the subject was instructed to look at the stimulus, and an antisaccade gap task during which the subject had to look in the opposite direction of the stimulus. Latency and direction were analyzed. These parameters were compared between patients with migraine (n = 80) and controls (n = 87). Results Our results suggested a greater latency variability in migraine patients (pro-gap P = 0.002 and pro-overlap P = 0.004). The latency of the prosaccades with gap was borderline increased in migraine (P = 0.042). Migraine patients on prophylactic therapy made significantly more directional errors than controls in the antisaccade gap task (P = 0.001). The group on prophylaxis had on average 10.66 days migraine per month, those who did not take prophylactic medication had on average 3.85 migraine days a month. No significant differences were found between migraine patients with and without aura for all parameters studied. Conclusion We found abnormal saccade behaviour in migraine patients, especially more antisaccade errors in patients on prophylactic drugs, suggesting it is related to migraine frequency. We hypothesize that grey matter changes in the prefrontal and cingulate cortex account for this abnormal antisaccade behaviour. 1. Cephalalgia 2008;28(6):598-604. 2. Cephalalgia 2008;28(1):1-4. 3. Headache 2008;48:109-17. 4. Cephalalgia 2009;30(1):53-61. 5. Ann N Y Acad Sci 2005;1039:239-51.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
Migraine, infrared-oculography, anti-saccade, Saccades
in
JOURNAL OF HEADACHE AND PAIN
J. Headache Pain
volume
11
issue
suppl. 1
article_number
abstract 244
pages
S52 - S52
conference name
2nd European Headache and Migraine Trust international congress (EHMTIC 2010)
conference location
Nice, France
conference start
2010-10-28
conference end
2010-10-31
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.015 (2010)
JCR rank
91/185 (2010)
JCR quartile
2 (2010)
ISSN
1129-2369
language
English
UGent publication?
yes
classification
C3
id
1068617
handle
http://hdl.handle.net/1854/LU-1068617
alternative location
http://www.springerlink.com/content/1129-2369/11/s1/
date created
2010-11-02 11:23:24
date last changed
2011-04-29 17:04:52
@inproceedings{1068617,
  abstract     = {Aim Recent voxel-based morphometry studies in migraine patients have shown subtle but significant reductions in grey matter in cortical areas involved in pain processing (including the prefrontal and cingulate cortices), which are related to migraine frequency. (1-5) We hypothesized these changes would be reflected in the control of saccadic eye movements.
Methods Saccades were recorded by infrared-oculography. Three tasks were performed: a prosaccade gap and overlap task during which the subject was instructed to look at the stimulus, and an antisaccade gap task during which the subject had to look in the opposite direction of the stimulus. Latency and direction were analyzed. These parameters were compared between patients with migraine (n = 80) and controls (n = 87).
Results Our results suggested a greater latency variability in migraine patients (pro-gap P = 0.002 and pro-overlap P = 0.004). The latency of the prosaccades with gap was borderline increased in migraine (P = 0.042). Migraine patients on prophylactic therapy made significantly more directional errors than controls in the antisaccade gap task (P = 0.001). The group on prophylaxis had on average 10.66 days migraine per month, those who did not take prophylactic medication had on average 3.85 migraine days a month. No significant differences were found between migraine patients with and without aura for all parameters studied.
Conclusion We found abnormal saccade behaviour in migraine patients, especially more antisaccade errors in patients on prophylactic drugs, suggesting it is related to migraine frequency. We hypothesize that grey matter changes in the prefrontal and cingulate cortex account for this abnormal antisaccade behaviour.
1. Cephalalgia 2008;28(6):598-604.
2. Cephalalgia 2008;28(1):1-4.
3. Headache 2008;48:109-17.
4. Cephalalgia 2009;30(1):53-61.
5. Ann N Y Acad Sci 2005;1039:239-51.},
  articleno    = {abstract 244},
  author       = {Cambron, Melissa and Anseeuw, Shari and Paemeleire, Koen and Crevits, Luc},
  booktitle    = {JOURNAL OF HEADACHE AND PAIN},
  issn         = {1129-2369},
  keyword      = {Migraine,infrared-oculography,anti-saccade,Saccades},
  language     = {eng},
  location     = {Nice, France},
  number       = {suppl. 1},
  pages        = {abstract 244:S52--abstract 244:S52},
  title        = {More antisaccade errors in migraine patients},
  url          = {http://www.springerlink.com/content/1129-2369/11/s1/},
  volume       = {11},
  year         = {2010},
}

Chicago
Cambron, Melissa, Shari Anseeuw, Koen Paemeleire, and Luc Crevits. 2010. “More Antisaccade Errors in Migraine Patients.” In Journal of Headache and Pain, 11:S52–S52.
APA
Cambron, M., Anseeuw, S., Paemeleire, K., & Crevits, L. (2010). More antisaccade errors in migraine patients. JOURNAL OF HEADACHE AND PAIN (Vol. 11, pp. S52–S52). Presented at the 2nd European Headache and Migraine Trust international congress (EHMTIC 2010).
Vancouver
1.
Cambron M, Anseeuw S, Paemeleire K, Crevits L. More antisaccade errors in migraine patients. JOURNAL OF HEADACHE AND PAIN. 2010. p. S52–S52.
MLA
Cambron, Melissa, Shari Anseeuw, Koen Paemeleire, et al. “More Antisaccade Errors in Migraine Patients.” Journal of Headache and Pain. Vol. 11. 2010. S52–S52. Print.