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Role for neutrophils in host immune responses and genetic factors that modulate resistance to Salmonella enterica serovar Typhimurium in the inbred mouse strain SPRET/Ei

Lien Dejager, Iris Pinheiro UGent, Pieter Bogaert UGent, Liesbeth Huys and Claude Libert UGent (2010) INFECTION AND IMMUNITY. 78(9). p.3848-3860
abstract
Infection with Salmonella enterica serovar Typhimurium is a complex disease in which the host-bacterium interactions are strongly influenced by genetic factors of the host. We demonstrate that SPRET/Ei, an inbred mouse strain derived from Mus spretus, is resistant to S. Typhimurium infections. The kinetics of bacterial proliferation, as well as histological examinations of tissue sections, suggest that SPRET/Ei mice can control bacterial multiplication and spreading despite significant attenuation of the cytokine response. The resistance of SPRET/Ei mice to S. Typhimurium infection is associated with increased leukocyte counts in the circulation and enhanced neutrophil influx into the peritoneum during the course of infection. A critical role of neutrophils was confirmed by neutrophil depletion: neutropenic SPRET/Ei mice were sensitive to infection with S. Typhimurium and showed much higher bacterial loads. To identify genes that modulate the natural resistance of SPRET/Ei mice to S. Typhimurium infection, we performed a genome-wide study using an interspecific backcross between C3H/HeN and SPRET/Ei mice. The results of this analysis demonstrate that at least two loci, located on chromosomes 6 and 11, affect survival following lethal infection with S. Typhimurium. These two loci contain several interesting candidate genes which may have important implications for the search for genetic factors controlling Salmonella infections in humans and for our understanding of complex hostpathogen interactions in general.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
INTRACELLULAR PARASITES, NATURAL-RESISTANCE, TOLL-LIKE RECEPTORS, NITRIC-OXIDE SYNTHASE, CYTOKINE RESPONSE, T-CELLS, IN-VIVO, INDEPENDENT MECHANISMS, BACTERIAL-INFECTION, CHEMOKINE RECEPTOR
journal title
INFECTION AND IMMUNITY
Infect. Immun.
volume
78
issue
9
pages
3848 - 3860
Web of Science type
Article
Web of Science id
000280986700020
JCR category
INFECTIOUS DISEASES
JCR impact factor
4.098 (2010)
JCR rank
11/57 (2010)
JCR quartile
1 (2010)
ISSN
0019-9567
DOI
10.1128/IAI.00044-10
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1062755
handle
http://hdl.handle.net/1854/LU-1062755
date created
2010-10-22 13:45:02
date last changed
2016-12-19 15:46:27
@article{1062755,
  abstract     = {Infection with Salmonella enterica serovar Typhimurium is a complex disease in which the host-bacterium interactions are strongly influenced by genetic factors of the host. We demonstrate that SPRET/Ei, an inbred mouse strain derived from Mus spretus, is resistant to S. Typhimurium infections. The kinetics of bacterial proliferation, as well as histological examinations of tissue sections, suggest that SPRET/Ei mice can control bacterial multiplication and spreading despite significant attenuation of the cytokine response. The resistance of SPRET/Ei mice to S. Typhimurium infection is associated with increased leukocyte counts in the circulation and enhanced neutrophil influx into the peritoneum during the course of infection. A critical role of neutrophils was confirmed by neutrophil depletion: neutropenic SPRET/Ei mice were sensitive to infection with S. Typhimurium and showed much higher bacterial loads. To identify genes that modulate the natural resistance of SPRET/Ei mice to S. Typhimurium infection, we performed a genome-wide study using an interspecific backcross between C3H/HeN and SPRET/Ei mice. The results of this analysis demonstrate that at least two loci, located on chromosomes 6 and 11, affect survival following lethal infection with S. Typhimurium. These two loci contain several interesting candidate genes which may have important implications for the search for genetic factors controlling Salmonella infections in humans and for our understanding of complex hostpathogen interactions in general.},
  author       = {Dejager, Lien and Pinheiro, Iris and Bogaert, Pieter and Huys, Liesbeth and Libert, Claude},
  issn         = {0019-9567},
  journal      = {INFECTION AND IMMUNITY},
  keyword      = {INTRACELLULAR PARASITES,NATURAL-RESISTANCE,TOLL-LIKE RECEPTORS,NITRIC-OXIDE SYNTHASE,CYTOKINE RESPONSE,T-CELLS,IN-VIVO,INDEPENDENT MECHANISMS,BACTERIAL-INFECTION,CHEMOKINE RECEPTOR},
  language     = {eng},
  number       = {9},
  pages        = {3848--3860},
  title        = {Role for neutrophils in host immune responses and genetic factors that modulate resistance to Salmonella enterica serovar Typhimurium in the inbred mouse strain SPRET/Ei},
  url          = {http://dx.doi.org/10.1128/IAI.00044-10},
  volume       = {78},
  year         = {2010},
}

Chicago
Dejager, Lien, Iris Pinheiro, Pieter Bogaert, LIESBETH HUYS, and Claude Libert. 2010. “Role for Neutrophils in Host Immune Responses and Genetic Factors That Modulate Resistance to Salmonella Enterica Serovar Typhimurium in the Inbred Mouse Strain SPRET/Ei.” Infection and Immunity 78 (9): 3848–3860.
APA
Dejager, L., Pinheiro, I., Bogaert, P., HUYS, L., & Libert, C. (2010). Role for neutrophils in host immune responses and genetic factors that modulate resistance to Salmonella enterica serovar Typhimurium in the inbred mouse strain SPRET/Ei. INFECTION AND IMMUNITY, 78(9), 3848–3860.
Vancouver
1.
Dejager L, Pinheiro I, Bogaert P, HUYS L, Libert C. Role for neutrophils in host immune responses and genetic factors that modulate resistance to Salmonella enterica serovar Typhimurium in the inbred mouse strain SPRET/Ei. INFECTION AND IMMUNITY. 2010;78(9):3848–60.
MLA
Dejager, Lien, Iris Pinheiro, Pieter Bogaert, et al. “Role for Neutrophils in Host Immune Responses and Genetic Factors That Modulate Resistance to Salmonella Enterica Serovar Typhimurium in the Inbred Mouse Strain SPRET/Ei.” INFECTION AND IMMUNITY 78.9 (2010): 3848–3860. Print.