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From vascular corrosion cast to electrical analog model for the study of human liver hemodynamics and perfusion

Charlotte Debbaut UGent, Diethard Monbaliu, Christophe Casteleyn UGent, Pieter Cornillie UGent, Denis Van Loo, Bert Masschaele UGent, Jacques Pirenne, Paul Simoens, Luc Van Hoorebeke UGent and Patrick Segers UGent (2011) IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 58(1). p.25-35
abstract
Hypothermic machine perfusion (HMP) is experiencing a revival in organ preservation due to the limitations of static cold storage and the need for better preservation of expanded criteria donor organs. For livers, perfusion protocols are still poorly defined, and damage of sinusoidal endothelial cells and heterogeneous perfusion are concerns. In this study, an electrical model of the human liver blood circulation is developed to enlighten internal pressure and flow distributions during HMP. Detailed vascular data on two human livers, obtained by combining vascular corrosion casting, micro-CT-imaging and image processing, were used to set up the electrical model. Anatomical data could be measured up to 5-6 vessel generations in each tree and showed exponential trend lines, used to predict data for higher generations. Simulated flow and pressure were in accordance with literature data. The model was able to simulate effects of pressure-driven HMP on liver hemodynamics and reproduced observations such as flow competition between the hepatic artery and portal vein. Our simulations further indicate that, from a pure biomechanical (shear stress) standpoint, HMP with low pressures should not result in organ damage, and that fluid viscosity has no effect on the shear stress experienced by the liver microcirculation in pressure-driven HMP.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
biomedical image processing, fluid dynamics, biomedical engineering., liver, biological system modeling
journal title
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
IEEE Trans. Biomed. Eng.
volume
58
issue
1
pages
25 - 35
Web of Science type
Article
Web of Science id
000285515500005
JCR category
ENGINEERING, BIOMEDICAL
JCR impact factor
2.278 (2011)
JCR rank
22/72 (2011)
JCR quartile
2 (2011)
ISSN
0018-9294
DOI
10.1109/TBME.2010.2065229
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1061826
handle
http://hdl.handle.net/1854/LU-1061826
date created
2010-10-21 13:32:35
date last changed
2016-12-19 15:46:43
@article{1061826,
  abstract     = {Hypothermic machine perfusion (HMP) is experiencing a revival in organ preservation due to the limitations of static cold storage and the need for better preservation of expanded criteria donor organs. For livers, perfusion protocols are still poorly defined, and damage of sinusoidal endothelial cells and heterogeneous perfusion are concerns. In this study, an electrical model of the human liver blood circulation is developed to enlighten internal pressure and flow distributions during HMP. Detailed vascular data on two human livers, obtained by combining vascular corrosion casting, micro-CT-imaging and image processing, were used to set up the electrical model. Anatomical data could be measured up to 5-6 vessel generations in each tree and showed exponential trend lines, used to predict data for higher generations. Simulated flow and pressure were in accordance with literature data. The model was able to simulate effects of pressure-driven HMP on liver hemodynamics and reproduced observations such as flow competition between the hepatic artery and portal vein. Our simulations further indicate that, from a pure biomechanical (shear stress) standpoint, HMP with low pressures should not result in organ damage, and that fluid viscosity has no effect on the shear stress experienced by the liver microcirculation in pressure-driven HMP.},
  author       = {Debbaut, Charlotte and Monbaliu, Diethard and Casteleyn, Christophe and Cornillie, Pieter and Van Loo, Denis and Masschaele, Bert and Pirenne, Jacques and Simoens, Paul and Van Hoorebeke, Luc and Segers, Patrick},
  issn         = {0018-9294},
  journal      = {IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING},
  keyword      = {biomedical image processing,fluid dynamics,biomedical engineering.,liver,biological system modeling},
  language     = {eng},
  number       = {1},
  pages        = {25--35},
  title        = {From vascular corrosion cast to electrical analog model for the study of human liver hemodynamics and perfusion},
  url          = {http://dx.doi.org/10.1109/TBME.2010.2065229},
  volume       = {58},
  year         = {2011},
}

Chicago
Debbaut, Charlotte, Diethard Monbaliu, Christophe Casteleyn, Pieter Cornillie, Denis Van Loo, Bert Masschaele, Jacques Pirenne, Paul Simoens, Luc Van Hoorebeke, and Patrick Segers. 2011. “From Vascular Corrosion Cast to Electrical Analog Model for the Study of Human Liver Hemodynamics and Perfusion.” Ieee Transactions on Biomedical Engineering 58 (1): 25–35.
APA
Debbaut, C., Monbaliu, D., Casteleyn, C., Cornillie, P., Van Loo, D., Masschaele, B., Pirenne, J., et al. (2011). From vascular corrosion cast to electrical analog model for the study of human liver hemodynamics and perfusion. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 58(1), 25–35.
Vancouver
1.
Debbaut C, Monbaliu D, Casteleyn C, Cornillie P, Van Loo D, Masschaele B, et al. From vascular corrosion cast to electrical analog model for the study of human liver hemodynamics and perfusion. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 2011;58(1):25–35.
MLA
Debbaut, Charlotte, Diethard Monbaliu, Christophe Casteleyn, et al. “From Vascular Corrosion Cast to Electrical Analog Model for the Study of Human Liver Hemodynamics and Perfusion.” IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 58.1 (2011): 25–35. Print.