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Molecular mechanisms of necroptosis: an ordered cellular explosion

Peter Vandenabeele UGent, Lorenzo Galluzzi, Tom Vanden Berghe UGent and Guido Kroemer (2010) NATURE REVIEWS MOLECULAR CELL BIOLOGY. 11(10). p.700-714
abstract
For a long time, apoptosis was considered the sole form of programmed cell death during development, homeostasis and disease, whereas necrosis was regarded as an unregulated and uncontrollable process. Evidence now reveals that necrosis can also occur in a regulated manner. The initiation of programmed necrosis, ‘necroptosis’, by death receptors (such as tumour necrosis factor receptor 1) requires the kinase activity of receptorinteracting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3), and its execution involves the active disintegration of mitochondrial, lysosomal and plasma membranes. Necroptosis participates in the pathogenesis of diseases, including ischaemic injury, neurodegeneration and viral infection, thereby representing an attractive target for the avoidance of unwarranted cell death.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
NF-KAPPA-B, MITOCHONDRIAL PERMEABILITY TRANSITION, RECEPTOR-INTERACTING PROTEIN, TUMOR-NECROSIS-FACTOR, APOPTOSIS-INDUCING FACTOR, LYSOSOMAL MEMBRANE PERMEABILIZATION, MEDIATED PROGRAMMED NECROSIS, FOCAL CEREBRAL-ISCHEMIA, DEATH DOMAIN KINASE, OXIDATIVE STRESS
journal title
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Nat. Rev. Mol. Cell Biol.
volume
11
issue
10
pages
700 - 714
Web of Science type
Review
Web of Science id
000282152800013
JCR category
CELL BIOLOGY
JCR impact factor
38.65 (2010)
JCR rank
1/174 (2010)
JCR quartile
1 (2010)
ISSN
1471-0072
DOI
10.1038/nrm2970
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1060142
handle
http://hdl.handle.net/1854/LU-1060142
date created
2010-10-18 14:47:23
date last changed
2016-12-19 15:44:34
@article{1060142,
  abstract     = {For a long time, apoptosis was considered the sole form of programmed cell death during development, homeostasis and disease, whereas necrosis was regarded as an unregulated and uncontrollable process. Evidence now reveals that necrosis can also occur in a regulated manner. The initiation of programmed necrosis, {\textquoteleft}necroptosis{\textquoteright}, by death receptors (such as tumour necrosis factor receptor 1) requires the kinase activity of receptorinteracting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3), and its execution involves the active disintegration of mitochondrial, lysosomal and plasma membranes. Necroptosis participates in the pathogenesis of diseases, including ischaemic injury, neurodegeneration and viral infection, thereby representing an attractive target for the avoidance of unwarranted cell death.},
  author       = {Vandenabeele, Peter and Galluzzi, Lorenzo and Vanden Berghe, Tom and Kroemer, Guido},
  issn         = {1471-0072},
  journal      = {NATURE REVIEWS MOLECULAR CELL BIOLOGY},
  keyword      = {NF-KAPPA-B,MITOCHONDRIAL PERMEABILITY TRANSITION,RECEPTOR-INTERACTING PROTEIN,TUMOR-NECROSIS-FACTOR,APOPTOSIS-INDUCING FACTOR,LYSOSOMAL MEMBRANE PERMEABILIZATION,MEDIATED PROGRAMMED NECROSIS,FOCAL CEREBRAL-ISCHEMIA,DEATH DOMAIN KINASE,OXIDATIVE STRESS},
  language     = {eng},
  number       = {10},
  pages        = {700--714},
  title        = {Molecular mechanisms of necroptosis: an ordered cellular explosion},
  url          = {http://dx.doi.org/10.1038/nrm2970},
  volume       = {11},
  year         = {2010},
}

Chicago
Vandenabeele, Peter, Lorenzo Galluzzi, Tom Vanden Berghe, and Guido Kroemer. 2010. “Molecular Mechanisms of Necroptosis: An Ordered Cellular Explosion.” Nature Reviews Molecular Cell Biology 11 (10): 700–714.
APA
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010). Molecular mechanisms of necroptosis: an ordered cellular explosion. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 11(10), 700–714.
Vancouver
1.
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2010;11(10):700–14.
MLA
Vandenabeele, Peter, Lorenzo Galluzzi, Tom Vanden Berghe, et al. “Molecular Mechanisms of Necroptosis: An Ordered Cellular Explosion.” NATURE REVIEWS MOLECULAR CELL BIOLOGY 11.10 (2010): 700–714. Print.