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Molecular mechanisms of necroptosis: an ordered cellular explosion

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Abstract
For a long time, apoptosis was considered the sole form of programmed cell death during development, homeostasis and disease, whereas necrosis was regarded as an unregulated and uncontrollable process. Evidence now reveals that necrosis can also occur in a regulated manner. The initiation of programmed necrosis, ‘necroptosis’, by death receptors (such as tumour necrosis factor receptor 1) requires the kinase activity of receptorinteracting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3), and its execution involves the active disintegration of mitochondrial, lysosomal and plasma membranes. Necroptosis participates in the pathogenesis of diseases, including ischaemic injury, neurodegeneration and viral infection, thereby representing an attractive target for the avoidance of unwarranted cell death.
Keywords
NF-KAPPA-B, MITOCHONDRIAL PERMEABILITY TRANSITION, RECEPTOR-INTERACTING PROTEIN, TUMOR-NECROSIS-FACTOR, APOPTOSIS-INDUCING FACTOR, LYSOSOMAL MEMBRANE PERMEABILIZATION, MEDIATED PROGRAMMED NECROSIS, FOCAL CEREBRAL-ISCHEMIA, DEATH DOMAIN KINASE, OXIDATIVE STRESS

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Citation

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Chicago
Vandenabeele, Peter, Lorenzo Galluzzi, Tom Vanden Berghe, and Guido Kroemer. 2010. “Molecular Mechanisms of Necroptosis: An Ordered Cellular Explosion.” Nature Reviews Molecular Cell Biology 11 (10): 700–714.
APA
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010). Molecular mechanisms of necroptosis: an ordered cellular explosion. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 11(10), 700–714.
Vancouver
1.
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2010;11(10):700–14.
MLA
Vandenabeele, Peter, Lorenzo Galluzzi, Tom Vanden Berghe, et al. “Molecular Mechanisms of Necroptosis: An Ordered Cellular Explosion.” NATURE REVIEWS MOLECULAR CELL BIOLOGY 11.10 (2010): 700–714. Print.
@article{1060142,
  abstract     = {For a long time, apoptosis was considered the sole form of programmed cell death during development, homeostasis and disease, whereas necrosis was regarded as an unregulated and uncontrollable process. Evidence now reveals that necrosis can also occur in a regulated manner. The initiation of programmed necrosis, {\textquoteleft}necroptosis{\textquoteright}, by death receptors (such as tumour necrosis factor receptor 1) requires the kinase activity of receptorinteracting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3), and its execution involves the active disintegration of mitochondrial, lysosomal and plasma membranes. Necroptosis participates in the pathogenesis of diseases, including ischaemic injury, neurodegeneration and viral infection, thereby representing an attractive target for the avoidance of unwarranted cell death.},
  author       = {Vandenabeele, Peter and Galluzzi, Lorenzo and Vanden Berghe, Tom and Kroemer, Guido},
  issn         = {1471-0072},
  journal      = {NATURE REVIEWS MOLECULAR CELL BIOLOGY},
  keyword      = {NF-KAPPA-B,MITOCHONDRIAL PERMEABILITY TRANSITION,RECEPTOR-INTERACTING PROTEIN,TUMOR-NECROSIS-FACTOR,APOPTOSIS-INDUCING FACTOR,LYSOSOMAL MEMBRANE PERMEABILIZATION,MEDIATED PROGRAMMED NECROSIS,FOCAL CEREBRAL-ISCHEMIA,DEATH DOMAIN KINASE,OXIDATIVE STRESS},
  language     = {eng},
  number       = {10},
  pages        = {700--714},
  title        = {Molecular mechanisms of necroptosis: an ordered cellular explosion},
  url          = {http://dx.doi.org/10.1038/nrm2970},
  volume       = {11},
  year         = {2010},
}

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