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An oxygen-consuming phantom simulating perfused tissue to explore oxygen dynamics and F-19 MRI oximetry

Steven Baete UGent, Jan Vandecasteele UGent, Luc Colman UGent, Wilfried De Neve UGent and Yves De Deene UGent (2010) MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 23(4). p.217-226
abstract
This study presents a reproducible phantom which mimics oxygen-consuming tissue and can be used for the validation of F-19 MRI oximetry. The phantom consists of a haemodialysis filter of which the outer compartment is filled with a gelatin matrix containing viable yeast cells. Perfluorocarbon emulsions can be added to the gelatin matrix to simulate sequestered perfluorocarbons. A blood-substituting perfluorocarbon fluid is pumped through the lumen of the fibres in the filter. F-19 relaxometry MRI is performed with a fast 2D Look-Locker imaging sequence on a clinical 3T scanner. Acute and perfusion-related hypoxia were simulated and imaged spatially and temporally using the phantom. The presented experimental setup can be used to simulate oxygen consumption by somatic cells in vivo and for validating computational biophysical models of hypoxia, as measured with F-19 MRI oximetry.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
RADIATION RESPONSE, NMR-SPECTROSCOPY, RESPIRATORY CHALLENGE, IN-VIVO, MAGNETIC-RESONANCE, TUMOR VASCULAR OXYGENATION, NEAR-INFRARED SPECTROSCOPY, Fast T-1-imaging, Quantitative magnetic resonance imaging (qMRI), F-19 MRI oximetry, Phantom, Tumour hypoxia, PERFLUOROCARBON, RAT-TUMOR, BLOOD SUBSTITUTE
journal title
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Magn. Reson. Mat. Phys. Biol. Med.
volume
23
issue
4
pages
217 - 226
Web of Science type
Article
Web of Science id
000281250700003
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
2.373 (2010)
JCR rank
45/111 (2010)
JCR quartile
2 (2010)
ISSN
0968-5243
DOI
10.1007/s10334-010-0219-6
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1058854
handle
http://hdl.handle.net/1854/LU-1058854
date created
2010-10-14 11:55:52
date last changed
2011-09-22 10:17:57
@article{1058854,
  abstract     = {This study presents a reproducible phantom which mimics oxygen-consuming tissue and can be used for the validation of F-19 MRI oximetry.
The phantom consists of a haemodialysis filter of which the outer compartment is filled with a gelatin matrix containing viable yeast cells. Perfluorocarbon emulsions can be added to the gelatin matrix to simulate sequestered perfluorocarbons. A blood-substituting perfluorocarbon fluid is pumped through the lumen of the fibres in the filter. F-19 relaxometry MRI is performed with a fast 2D Look-Locker imaging sequence on a clinical 3T scanner.
Acute and perfusion-related hypoxia were simulated and imaged spatially and temporally using the phantom.
The presented experimental setup can be used to simulate oxygen consumption by somatic cells in vivo and for validating computational biophysical models of hypoxia, as measured with F-19 MRI oximetry.},
  author       = {Baete, Steven and Vandecasteele, Jan and Colman, Luc and De Neve, Wilfried and De Deene, Yves},
  issn         = {0968-5243},
  journal      = {MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE},
  keyword      = {RADIATION RESPONSE,NMR-SPECTROSCOPY,RESPIRATORY CHALLENGE,IN-VIVO,MAGNETIC-RESONANCE,TUMOR VASCULAR OXYGENATION,NEAR-INFRARED SPECTROSCOPY,Fast T-1-imaging,Quantitative magnetic resonance imaging (qMRI),F-19 MRI oximetry,Phantom,Tumour hypoxia,PERFLUOROCARBON,RAT-TUMOR,BLOOD SUBSTITUTE},
  language     = {eng},
  number       = {4},
  pages        = {217--226},
  title        = {An oxygen-consuming phantom simulating perfused tissue to explore oxygen dynamics and F-19 MRI oximetry},
  url          = {http://dx.doi.org/10.1007/s10334-010-0219-6},
  volume       = {23},
  year         = {2010},
}

Chicago
Baete, Steven, Jan Vandecasteele, Luc Colman, Wilfried De Neve, and Yves De Deene. 2010. “An Oxygen-consuming Phantom Simulating Perfused Tissue to Explore Oxygen Dynamics and F-19 MRI Oximetry.” Magnetic Resonance Materials in Physics Biology and Medicine 23 (4): 217–226.
APA
Baete, S., Vandecasteele, J., Colman, L., De Neve, W., & De Deene, Y. (2010). An oxygen-consuming phantom simulating perfused tissue to explore oxygen dynamics and F-19 MRI oximetry. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, 23(4), 217–226.
Vancouver
1.
Baete S, Vandecasteele J, Colman L, De Neve W, De Deene Y. An oxygen-consuming phantom simulating perfused tissue to explore oxygen dynamics and F-19 MRI oximetry. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 2010;23(4):217–26.
MLA
Baete, Steven, Jan Vandecasteele, Luc Colman, et al. “An Oxygen-consuming Phantom Simulating Perfused Tissue to Explore Oxygen Dynamics and F-19 MRI Oximetry.” MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE 23.4 (2010): 217–226. Print.