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An oxygen-consuming phantom simulating perfused tissue to explore oxygen dynamics and F-19 MRI oximetry

Steven Baete (UGent) , Jan Vandecasteele (UGent) , Luc Colman (UGent) , Wilfried De Neve (UGent) and Yves De Deene (UGent)
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Abstract
This study presents a reproducible phantom which mimics oxygen-consuming tissue and can be used for the validation of F-19 MRI oximetry. The phantom consists of a haemodialysis filter of which the outer compartment is filled with a gelatin matrix containing viable yeast cells. Perfluorocarbon emulsions can be added to the gelatin matrix to simulate sequestered perfluorocarbons. A blood-substituting perfluorocarbon fluid is pumped through the lumen of the fibres in the filter. F-19 relaxometry MRI is performed with a fast 2D Look-Locker imaging sequence on a clinical 3T scanner. Acute and perfusion-related hypoxia were simulated and imaged spatially and temporally using the phantom. The presented experimental setup can be used to simulate oxygen consumption by somatic cells in vivo and for validating computational biophysical models of hypoxia, as measured with F-19 MRI oximetry.
Keywords
RADIATION RESPONSE, NMR-SPECTROSCOPY, RESPIRATORY CHALLENGE, IN-VIVO, MAGNETIC-RESONANCE, TUMOR VASCULAR OXYGENATION, NEAR-INFRARED SPECTROSCOPY, Fast T-1-imaging, Quantitative magnetic resonance imaging (qMRI), F-19 MRI oximetry, Phantom, Tumour hypoxia, PERFLUOROCARBON, RAT-TUMOR, BLOOD SUBSTITUTE

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Citation

Please use this url to cite or link to this publication:

Chicago
Baete, Steven, Jan Vandecasteele, Luc Colman, Wilfried De Neve, and Yves De Deene. 2010. “An Oxygen-consuming Phantom Simulating Perfused Tissue to Explore Oxygen Dynamics and F-19 MRI Oximetry.” Magnetic Resonance Materials in Physics Biology and Medicine 23 (4): 217–226.
APA
Baete, S., Vandecasteele, J., Colman, L., De Neve, W., & De Deene, Y. (2010). An oxygen-consuming phantom simulating perfused tissue to explore oxygen dynamics and F-19 MRI oximetry. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, 23(4), 217–226.
Vancouver
1.
Baete S, Vandecasteele J, Colman L, De Neve W, De Deene Y. An oxygen-consuming phantom simulating perfused tissue to explore oxygen dynamics and F-19 MRI oximetry. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 2010;23(4):217–26.
MLA
Baete, Steven, Jan Vandecasteele, Luc Colman, et al. “An Oxygen-consuming Phantom Simulating Perfused Tissue to Explore Oxygen Dynamics and F-19 MRI Oximetry.” MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE 23.4 (2010): 217–226. Print.
@article{1058854,
  abstract     = {This study presents a reproducible phantom which mimics oxygen-consuming tissue and can be used for the validation of F-19 MRI oximetry.
The phantom consists of a haemodialysis filter of which the outer compartment is filled with a gelatin matrix containing viable yeast cells. Perfluorocarbon emulsions can be added to the gelatin matrix to simulate sequestered perfluorocarbons. A blood-substituting perfluorocarbon fluid is pumped through the lumen of the fibres in the filter. F-19 relaxometry MRI is performed with a fast 2D Look-Locker imaging sequence on a clinical 3T scanner.
Acute and perfusion-related hypoxia were simulated and imaged spatially and temporally using the phantom.
The presented experimental setup can be used to simulate oxygen consumption by somatic cells in vivo and for validating computational biophysical models of hypoxia, as measured with F-19 MRI oximetry.},
  author       = {Baete, Steven and Vandecasteele, Jan and Colman, Luc and De Neve, Wilfried and De Deene, Yves},
  issn         = {0968-5243},
  journal      = {MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE},
  keyword      = {RADIATION RESPONSE,NMR-SPECTROSCOPY,RESPIRATORY CHALLENGE,IN-VIVO,MAGNETIC-RESONANCE,TUMOR VASCULAR OXYGENATION,NEAR-INFRARED SPECTROSCOPY,Fast T-1-imaging,Quantitative magnetic resonance imaging (qMRI),F-19 MRI oximetry,Phantom,Tumour hypoxia,PERFLUOROCARBON,RAT-TUMOR,BLOOD SUBSTITUTE},
  language     = {eng},
  number       = {4},
  pages        = {217--226},
  title        = {An oxygen-consuming phantom simulating perfused tissue to explore oxygen dynamics and F-19 MRI oximetry},
  url          = {http://dx.doi.org/10.1007/s10334-010-0219-6},
  volume       = {23},
  year         = {2010},
}

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