Advanced search
1 file | 137.41 KB

Sexual violence, HSV-2 and HIV are important predictors for infertility in Rwanda

(2010) HUMAN REPRODUCTION. 25(10). p.2507-2515
Author
Organization
Abstract
In order to formulate cost-effective health interventions aimed at preventing infertility it is necessary to identify modifiable risk factors for infertility in sub-Saharan Africa. This case-control study examined potential predictors and their population attributable fraction (PAF%) for various infertility types including lifestyle factors, sexual behaviour and reproductive tract infections (RTIs). Sexually active women aged 21-45 year presenting with infertility problems at the infertility clinic of the Kigali University Teaching Hospital (n = 312), and fertile controls who recently delivered (n = 283) were surveyed together with their male partners. Participants were interviewed about socio-demographic characteristics, sexual behaviours and lifestyle factors, and were tested for HIV and RTIs. Variables significantly associated with tubal infertility were history of sexual violence [adjusted odds ratio (AOR) 2.41; 95% CI 1.36-4.25]; positive HIV (AOR 2.41; 95% CI 1.36-4.25), herpes simplex virus type 2 (HSV-2; AOR 1.67; 95% CI 1.03-2.71) and Chlamydia trachomatis serology (AOR 1.78; 95% CI 0.99-3.21), and current bacterial vaginosis by Amsel criteria (AOR 1.97; 95% CI 1.12-3.47). Among men, male factor infertility was associated with positive HIV (AOR 2.43; 95% CI 1.31-5.23) and HSV-2 serology (AOR 1.71; 95% CI 1.02-2.87) and current urologic abnormalities (AOR 2.38; 95% CI 1.01-5.31). Positive HSV-2 serostatus carried the greatest PAF% (26%) for tubal infertility, followed by positive HIV serostatus (20%) and history of sexual violence (17%). Although temporal relationships are difficult to ascertain, history of sexual violence, HSV-2 infection and HIV infection are important predictors of infertility in Rwanda.
Keywords
predictors, Africa, PELVIC-INFLAMMATORY-DISEASE, HERPES-SIMPLEX-VIRUS, IN-VITRO FERTILIZATION, SUB-SAHARAN AFRICA, TUBAL INFERTILITY, CHLAMYDIA-TRACHOMATIS, SOCIOECONOMIC-STATUS, BACTERIAL VAGINOSIS, ACUTE SALPINGITIS, RISK-FACTOR, male factor, tubal factor, infertility

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 137.41 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Dhont, Nathalie, J van de Wijgert, Stanley Lüchters, Mambo-Claude Muvunyi, J Vyankandondera, and Marleen Temmerman. 2010. “Sexual Violence, HSV-2 and HIV Are Important Predictors for Infertility in Rwanda.” Human Reproduction 25 (10): 2507–2515.
APA
Dhont, N., van de Wijgert, J., Lüchters, S., Muvunyi, M.-C., Vyankandondera, J., & Temmerman, M. (2010). Sexual violence, HSV-2 and HIV are important predictors for infertility in Rwanda. HUMAN REPRODUCTION, 25(10), 2507–2515.
Vancouver
1.
Dhont N, van de Wijgert J, Lüchters S, Muvunyi M-C, Vyankandondera J, Temmerman M. Sexual violence, HSV-2 and HIV are important predictors for infertility in Rwanda. HUMAN REPRODUCTION. 2010;25(10):2507–15.
MLA
Dhont, Nathalie, J van de Wijgert, Stanley Lüchters, et al. “Sexual Violence, HSV-2 and HIV Are Important Predictors for Infertility in Rwanda.” HUMAN REPRODUCTION 25.10 (2010): 2507–2515. Print.
@article{1056918,
  abstract     = {In order to formulate cost-effective health interventions aimed at preventing infertility it is necessary to identify modifiable risk factors for infertility in sub-Saharan Africa. This case-control study examined potential predictors and their population attributable fraction (PAF\%) for various infertility types including lifestyle factors, sexual behaviour and reproductive tract infections (RTIs).
Sexually active women aged 21-45 year presenting with infertility problems at the infertility clinic of the Kigali University Teaching Hospital (n = 312), and fertile controls who recently delivered (n = 283) were surveyed together with their male partners. Participants were interviewed about socio-demographic characteristics, sexual behaviours and lifestyle factors, and were tested for HIV and RTIs.
Variables significantly associated with tubal infertility were history of sexual violence [adjusted odds ratio (AOR) 2.41; 95\% CI 1.36-4.25]; positive HIV (AOR 2.41; 95\% CI 1.36-4.25), herpes simplex virus type 2 (HSV-2; AOR 1.67; 95\% CI 1.03-2.71) and Chlamydia trachomatis serology (AOR 1.78; 95\% CI 0.99-3.21), and current bacterial vaginosis by Amsel criteria (AOR 1.97; 95\% CI 1.12-3.47). Among men, male factor infertility was associated with positive HIV (AOR 2.43; 95\% CI 1.31-5.23) and HSV-2 serology (AOR 1.71; 95\% CI 1.02-2.87) and current urologic abnormalities (AOR 2.38; 95\% CI 1.01-5.31). Positive HSV-2 serostatus carried the greatest PAF\% (26\%) for tubal infertility, followed by positive HIV serostatus (20\%) and history of sexual violence (17\%).
Although temporal relationships are difficult to ascertain, history of sexual violence, HSV-2 infection and HIV infection are important predictors of infertility in Rwanda.},
  author       = {Dhont, Nathalie and van de Wijgert, J and L{\"u}chters, Stanley and Muvunyi, Mambo-Claude and Vyankandondera, J and Temmerman, Marleen},
  issn         = {0268-1161},
  journal      = {HUMAN REPRODUCTION},
  keyword      = {predictors,Africa,PELVIC-INFLAMMATORY-DISEASE,HERPES-SIMPLEX-VIRUS,IN-VITRO FERTILIZATION,SUB-SAHARAN AFRICA,TUBAL INFERTILITY,CHLAMYDIA-TRACHOMATIS,SOCIOECONOMIC-STATUS,BACTERIAL VAGINOSIS,ACUTE SALPINGITIS,RISK-FACTOR,male factor,tubal factor,infertility},
  language     = {eng},
  number       = {10},
  pages        = {2507--2515},
  title        = {Sexual violence, HSV-2 and HIV are important predictors for infertility in Rwanda},
  url          = {http://dx.doi.org/10.1093/humrep/deq189},
  volume       = {25},
  year         = {2010},
}

Altmetric
View in Altmetric
Web of Science
Times cited: