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SR 2D micro-XRF imaging on entire rat thin sections in view of a pharmacokinetic study of a new bromine containing drug agains tuberculosis

Björn De Samber UGent, Andrei Izmer UGent, Greet Janssen, Filip Cuyckens, Gerald Falkenberg, Karen Appel, Frank Vanhaecke UGent and Laszlo Vincze UGent (2011) Photon Science 2010 : highlights and HASYLAB annual report : author contributions.
abstract
Tuberculosis (TB) is a common and often deadly infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis in humans. Because of population growth, the absolute number of new cases is still increasing. Multi-drug-resistant tuberculosis (MDR-TB) is defined as resistance to the two most effective first-line TB drugs and is a public health issue in many developing countries, as treatment is longer and requires more expensive drugs. Recently, a new experimental diarylquinoline anti-tuberculosis drug was discovered at Janssen Pharmaceutica, referred to as TMC207 and shown in Fig. 1. Before TMC207 can be made commercially available, one of the necessary investigations is a thorough pharmacokinetic study to investigate its absorption, distribution, metabolism and excretion (ADME).
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (letterNote)
publication status
published
subject
keyword
TBC, synchrotron, pharmacokinetics, micro-XRF
journal title
Photon Science 2010 : highlights and HASYLAB annual report : author contributions
pages
2 pages
publisher
Deutsches Elektronen-Synchrotron (DESY). Hamburger Synchrotronstrahlungslabor (HASYLAB)
place of publication
Hamburg, Germany
language
English
UGent publication?
yes
classification
A4
additional info
online supplement to the main report
copyright statement
I have transferred the copyright for this publication to the publisher
id
1055721
handle
http://hdl.handle.net/1854/LU-1055721
alternative location
http://photon-science.desy.de/annual_report/files/2010/2010913.pdf
date created
2010-10-08 11:23:02
date last changed
2014-12-11 13:08:32
@article{1055721,
  abstract     = {Tuberculosis (TB) is a common and often deadly infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis in humans. Because of population growth, the absolute number of new cases is still increasing. Multi-drug-resistant tuberculosis (MDR-TB) is defined as resistance to the two most effective first-line TB drugs and is a public health issue in many developing countries, as treatment is longer and requires more expensive drugs. Recently, a new experimental diarylquinoline anti-tuberculosis drug was discovered at Janssen Pharmaceutica, referred to as TMC207 and shown in Fig. 1. Before TMC207 can be made commercially available, one of the necessary investigations is a thorough pharmacokinetic study to investigate its absorption, distribution, metabolism and excretion (ADME).},
  author       = {De Samber, Bj{\"o}rn and Izmer, Andrei and Janssen, Greet and Cuyckens, Filip and Falkenberg, Gerald and Appel, Karen and Vanhaecke, Frank and Vincze, Laszlo},
  journal      = {Photon Science 2010 : highlights and HASYLAB annual report : author contributions},
  keyword      = {TBC,synchrotron,pharmacokinetics,micro-XRF},
  language     = {eng},
  pages        = {2},
  publisher    = {Deutsches Elektronen-Synchrotron (DESY). Hamburger Synchrotronstrahlungslabor (HASYLAB)},
  title        = {SR 2D micro-XRF imaging on entire rat thin sections in view of a pharmacokinetic study of a new bromine containing drug agains tuberculosis},
  url          = {http://photon-science.desy.de/annual\_report/files/2010/2010913.pdf},
  year         = {2011},
}

Chicago
De Samber, Björn, Andrei Izmer, Greet Janssen, Filip Cuyckens, Gerald Falkenberg, Karen Appel, Frank Vanhaecke, and Laszlo Vincze. 2011. “SR 2D micro-XRF Imaging on Entire Rat Thin Sections in View of a Pharmacokinetic Study of a New Bromine Containing Drug Agains Tuberculosis.” Photon Science 2010 : Highlights and HASYLAB Annual Report : Author Contributions.
APA
De Samber, B., Izmer, A., Janssen, G., Cuyckens, F., Falkenberg, G., Appel, K., Vanhaecke, F., et al. (2011). SR 2D micro-XRF imaging on entire rat thin sections in view of a pharmacokinetic study of a new bromine containing drug agains tuberculosis. Photon Science 2010 : highlights and HASYLAB annual report : author contributions.
Vancouver
1.
De Samber B, Izmer A, Janssen G, Cuyckens F, Falkenberg G, Appel K, et al. SR 2D micro-XRF imaging on entire rat thin sections in view of a pharmacokinetic study of a new bromine containing drug agains tuberculosis. Photon Science 2010 : highlights and HASYLAB annual report : author contributions. Hamburg, Germany: Deutsches Elektronen-Synchrotron (DESY). Hamburger Synchrotronstrahlungslabor (HASYLAB); 2011;
MLA
De Samber, Björn, Andrei Izmer, Greet Janssen, et al. “SR 2D micro-XRF Imaging on Entire Rat Thin Sections in View of a Pharmacokinetic Study of a New Bromine Containing Drug Agains Tuberculosis.” Photon Science 2010 : highlights and HASYLAB annual report : author contributions (2011): n. pag. Print.