Advanced search
1 file | 10.43 MB Add to list

Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma

Author
Organization
Abstract
Background: The increasing incidence of hepatocellular carcinoma in Western countries has led to an expanding interest of scientific research in this field. Therefore, a vast need of experimental models that mimic the natural pathogenesis of hepatocellular carcinoma (HCC) in a short time period is present. The goal of our study was (1) to develop an efficient mouse model for HCC research, in which tumours develop in a natural background of fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of HCC. Methods: Weekly intraperitoneal injections with the hepatocarcinogenic compound N-nitrosodiethylamine was applied as induction method and samples were taken at several time points to assess the angiogenic changes during the progression of HCC. Results: The N-nitrosodiethylamine-induced mouse model provides well vascularised orthotopic tumours after 25 weeks. It is a representative model for human HCC and can serve as an excellent platform for the development of new therapeutic targets.
Keywords
hepatocellular carcinoma, diethylnitrosamine, angiogenesis, mouse models

Downloads

  • Molecular Cancer.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 10.43 MB

Citation

Please use this url to cite or link to this publication:

MLA
Heindryckx, Femke, et al. “Kinetics of Angiogenic Changes in a New Mouse Model for Hepatocellular Carcinoma.” MOLECULAR CANCER, vol. 9, 2010, doi:10.1186/1476-4598-9-219.
APA
Heindryckx, F., Mertens, K., Charette, N., Vandeghinste, B., Casteleyn, C., Van Steenkiste, C., … Van Vlierberghe, H. (2010). Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma. MOLECULAR CANCER, 9. https://doi.org/10.1186/1476-4598-9-219
Chicago author-date
Heindryckx, Femke, Koen Mertens, Nicolas Charette, Bert Vandeghinste, Christophe Casteleyn, Christophe Van Steenkiste, Dominique Slaets, et al. 2010. “Kinetics of Angiogenic Changes in a New Mouse Model for Hepatocellular Carcinoma.” MOLECULAR CANCER 9. https://doi.org/10.1186/1476-4598-9-219.
Chicago author-date (all authors)
Heindryckx, Femke, Koen Mertens, Nicolas Charette, Bert Vandeghinste, Christophe Casteleyn, Christophe Van Steenkiste, Dominique Slaets, Louis Libbrecht, Steven Staelens, Peter Starkel, Anja Geerts, Isabelle Colle, and Hans Van Vlierberghe. 2010. “Kinetics of Angiogenic Changes in a New Mouse Model for Hepatocellular Carcinoma.” MOLECULAR CANCER 9. doi:10.1186/1476-4598-9-219.
Vancouver
1.
Heindryckx F, Mertens K, Charette N, Vandeghinste B, Casteleyn C, Van Steenkiste C, et al. Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma. MOLECULAR CANCER. 2010;9.
IEEE
[1]
F. Heindryckx et al., “Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma,” MOLECULAR CANCER, vol. 9, 2010.
@article{1054780,
  abstract     = {{Background: The increasing incidence of hepatocellular carcinoma in Western countries has led to an expanding interest of scientific research in this field. Therefore, a vast need of experimental models that mimic the natural pathogenesis of hepatocellular carcinoma (HCC) in a short time period is present. The goal of our study was (1) to develop an efficient mouse model for HCC research, in which tumours develop in a natural background of fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of HCC.
Methods: Weekly intraperitoneal injections with the hepatocarcinogenic compound N-nitrosodiethylamine was applied as induction method and samples were taken at several time points to assess the angiogenic changes during the progression of HCC.
Results: The N-nitrosodiethylamine-induced mouse model provides well vascularised orthotopic tumours after 25 weeks. It is a representative model for human HCC and can serve as an excellent platform for the development of new therapeutic targets.}},
  articleno    = {{219}},
  author       = {{Heindryckx, Femke and Mertens, Koen and Charette, Nicolas and Vandeghinste, Bert and Casteleyn, Christophe and Van Steenkiste, Christophe and Slaets, Dominique and Libbrecht, Louis and Staelens, Steven and Starkel, Peter and Geerts, Anja and Colle, Isabelle and Van Vlierberghe, Hans}},
  issn         = {{1476-4598}},
  journal      = {{MOLECULAR CANCER}},
  keywords     = {{hepatocellular carcinoma,diethylnitrosamine,angiogenesis,mouse models}},
  language     = {{eng}},
  pages        = {{14}},
  title        = {{Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma}},
  url          = {{http://dx.doi.org/10.1186/1476-4598-9-219}},
  volume       = {{9}},
  year         = {{2010}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: