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Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases

Olga Krysko (UGent), Peter Vandenabeele (UGent), Dmitri Krysko (UGent) and Claus Bachert (UGent)
(2010) APOPTOSIS. 15(9). p.1137-1146
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Abstract
Phagocytosis of dying cells is a complex and dynamic process coordinated by the interaction of many surface molecules, adaptors, and chemotactic molecules, and it is controlled at multiple levels. This well regulated clearance process is of utmost importance for the development and homeostasis of organisms because defective or inefficient phagocytosis may contribute to human pathologies. In this review we discuss recent advances in the knowledge of the molecular interactions involved in recognition and clearance of apoptotic cells and how derangement of these processes can contribute to the pathogenesis of chronic airway diseases such as chronic obstructive pulmonary disease, cystic fibrosis and asthma. We will briefly consider how different types of macrophages are implicated in chronic airway diseases. Finally, we will address possible therapeutic strategies, such as the use of macrolide antibiotics and statins, for modulating apoptotic cell clearance.
Keywords
Asthma, Cystic fibrosis, Apoptosis, COPD, Clearance, Statins, Macrolides, OBSTRUCTIVE PULMONARY-DISEASE, SURFACTANT PROTEIN-A, ALVEOLAR MACROPHAGE PHAGOCYTOSIS, NECROSIS-FACTOR-ALPHA, HUMAN MONOCYTES DEMONSTRATION, BRONCHIAL EPITHELIAL-CELLS, CYSTIC-FIBROSIS PATIENTS, SMOKE-INDUCED EMPHYSEMA, MANNOSE-BINDING LECTIN, CIGARETTE-SMOKE

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Chicago
Krysko, Olga, Peter Vandenabeele, Dmitri Krysko, and Claus Bachert. 2010. “Impairment of Phagocytosis of Apoptotic Cells and Its Role in Chronic Airway Diseases.” Apoptosis 15 (9): 1137–1146.
APA
Krysko, O., Vandenabeele, P., Krysko, D., & Bachert, C. (2010). Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases. APOPTOSIS, 15(9), 1137–1146.
Vancouver
1.
Krysko O, Vandenabeele P, Krysko D, Bachert C. Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases. APOPTOSIS. 2010;15(9):1137–46.
MLA
Krysko, Olga, Peter Vandenabeele, Dmitri Krysko, et al. “Impairment of Phagocytosis of Apoptotic Cells and Its Role in Chronic Airway Diseases.” APOPTOSIS 15.9 (2010): 1137–1146. Print.
@article{1043249,
  abstract     = {Phagocytosis of dying cells is a complex and dynamic process coordinated by the interaction of many surface molecules, adaptors, and chemotactic molecules, and it is controlled at multiple levels. This well regulated clearance process is of utmost importance for the development and homeostasis of organisms because defective or inefficient phagocytosis may contribute to human pathologies. In this review we discuss recent advances in the knowledge of the molecular interactions involved in recognition and clearance of apoptotic cells and how derangement of these processes can contribute to the pathogenesis of chronic airway diseases such as chronic obstructive pulmonary disease, cystic fibrosis and asthma. We will briefly consider how different types of macrophages are implicated in chronic airway diseases. Finally, we will address possible therapeutic strategies, such as the use of macrolide antibiotics and statins, for modulating  apoptotic cell clearance.},
  author       = {Krysko, Olga and Vandenabeele, Peter and Krysko, Dmitri and Bachert, Claus},
  issn         = {1360-8185},
  journal      = {APOPTOSIS},
  keyword      = {Asthma,Cystic fibrosis,Apoptosis,COPD,Clearance,Statins,Macrolides,OBSTRUCTIVE PULMONARY-DISEASE,SURFACTANT PROTEIN-A,ALVEOLAR MACROPHAGE PHAGOCYTOSIS,NECROSIS-FACTOR-ALPHA,HUMAN MONOCYTES DEMONSTRATION,BRONCHIAL EPITHELIAL-CELLS,CYSTIC-FIBROSIS PATIENTS,SMOKE-INDUCED EMPHYSEMA,MANNOSE-BINDING LECTIN,CIGARETTE-SMOKE},
  language     = {eng},
  number       = {9},
  pages        = {1137--1146},
  title        = {Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases},
  url          = {http://dx.doi.org/10.1007/s10495-010-0504-x},
  volume       = {15},
  year         = {2010},
}

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