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1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique

Harmen Reyngoudt (UGent) , Yves De Deene (UGent) , Benedicte Descamps (UGent) , Koen Paemeleire (UGent) and Eric Achten (UGent)
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Abstract
Several studies have demonstrated differences in migraine patients when performing 1H-MRS; however, no studies have performed H-1-MRS in migraine without aura (MwoA), the most common migraine subtype. The aim of this 1H-MRS study was to elucidate whether any differences could be found between MwoA patients and controls by performing absolute quantification. 1H-MRS was performed in 22 MwoA patients and 25 control subjects. Absolute quantification was based on the phantom replacement technique. Corrections were made for T (1) and T (2) relaxation effects, CSF content, coil loading and temperature. The method was validated by phantom measurements and in vivo measurements in the occipital visual cortex. After calibration of the quantification procedure and the implementation of the required correction factors, measured absolute concentrations in the visual cortex of MwoA patients showed no significant differences compared to controls, in contrast to relative results obtained in earlier studies. In this study, we demonstrate the implementation of quantitative in vivo 1H-MRS spectroscopy in migraine patients. Despite rigorous quantification, no spectroscopic abnormalities could be found in patients with migraine without aura.
Keywords
LOCALIZED PROTON, RELAXATION-TIMES, IN-VIVO, HEMIPLEGIC MIGRAINE, CEREBRAL METABOLITES, N-ACETYL ASPARTATE, MUSCLE ENERGY-METABOLISM, NMR-SPECTROSCOPY, PROTON MR SPECTROSCOPY, absolute quantification, migraine without aura, H-1-MRS, phantom replacement technique, MAGNETIC-RESONANCE-SPECTROSCOPY, correction factors

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Citation

Please use this url to cite or link to this publication:

Chicago
Reyngoudt, Harmen, Yves De Deene, Benedicte Descamps, Koen Paemeleire, and Eric Achten. 2010. “1H-MRS of Brain Metabolites in Migraine Without Aura: Absolute Quantification Using the Phantom Replacement Technique.” Magnetic Resonance Materials in Physics Biology and Medicine 23 (4): 227–241.
APA
Reyngoudt, H., De Deene, Y., Descamps, B., Paemeleire, K., & Achten, E. (2010). 1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, 23(4), 227–241.
Vancouver
1.
Reyngoudt H, De Deene Y, Descamps B, Paemeleire K, Achten E. 1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 2010;23(4):227–41.
MLA
Reyngoudt, Harmen, Yves De Deene, Benedicte Descamps, et al. “1H-MRS of Brain Metabolites in Migraine Without Aura: Absolute Quantification Using the Phantom Replacement Technique.” MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE 23.4 (2010): 227–241. Print.
@article{1041248,
  abstract     = {Several studies have demonstrated differences in migraine patients when performing 1H-MRS; however, no studies have performed H-1-MRS in migraine without aura (MwoA), the most common migraine subtype. The aim of this 1H-MRS study was to elucidate whether any differences could be found between MwoA patients and controls by performing absolute quantification.
1H-MRS was performed in 22 MwoA patients and 25 control subjects. Absolute quantification was based on the phantom replacement technique. Corrections were made for T (1) and T (2) relaxation effects, CSF content, coil loading and temperature. The method was validated by phantom measurements and in vivo measurements in the occipital visual cortex.
After calibration of the quantification procedure and the implementation of the required correction factors, measured absolute concentrations in the visual cortex of MwoA patients showed no significant differences compared to controls, in contrast to relative results obtained in earlier studies.
In this study, we demonstrate the implementation of quantitative in vivo 1H-MRS spectroscopy in migraine patients. Despite rigorous quantification, no spectroscopic abnormalities could be found in patients with migraine without aura.},
  author       = {Reyngoudt, Harmen and De Deene, Yves and Descamps, Benedicte and Paemeleire, Koen and Achten, Eric},
  issn         = {0968-5243},
  journal      = {MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE},
  keyword      = {LOCALIZED PROTON,RELAXATION-TIMES,IN-VIVO,HEMIPLEGIC MIGRAINE,CEREBRAL METABOLITES,N-ACETYL ASPARTATE,MUSCLE ENERGY-METABOLISM,NMR-SPECTROSCOPY,PROTON MR SPECTROSCOPY,absolute quantification,migraine without aura,H-1-MRS,phantom replacement technique,MAGNETIC-RESONANCE-SPECTROSCOPY,correction factors},
  language     = {eng},
  number       = {4},
  pages        = {227--241},
  title        = {1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique},
  url          = {http://dx.doi.org/10.1007/s10334-010-0221-z},
  volume       = {23},
  year         = {2010},
}

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