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1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique

Harmen Reyngoudt UGent, Yves De Deene UGent, Benedicte Descamps UGent, Koen Paemeleire UGent and Eric Achten UGent (2010) MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 23(4). p.227-241
abstract
Several studies have demonstrated differences in migraine patients when performing 1H-MRS; however, no studies have performed H-1-MRS in migraine without aura (MwoA), the most common migraine subtype. The aim of this 1H-MRS study was to elucidate whether any differences could be found between MwoA patients and controls by performing absolute quantification. 1H-MRS was performed in 22 MwoA patients and 25 control subjects. Absolute quantification was based on the phantom replacement technique. Corrections were made for T (1) and T (2) relaxation effects, CSF content, coil loading and temperature. The method was validated by phantom measurements and in vivo measurements in the occipital visual cortex. After calibration of the quantification procedure and the implementation of the required correction factors, measured absolute concentrations in the visual cortex of MwoA patients showed no significant differences compared to controls, in contrast to relative results obtained in earlier studies. In this study, we demonstrate the implementation of quantitative in vivo 1H-MRS spectroscopy in migraine patients. Despite rigorous quantification, no spectroscopic abnormalities could be found in patients with migraine without aura.
Please use this url to cite or link to this publication:
author
organization
alternative title
H-1-MRS of brain metabolites in migraine without aura : absolute quantification using the phantom replacement technique
year
type
journalArticle (original)
publication status
published
subject
keyword
LOCALIZED PROTON, RELAXATION-TIMES, IN-VIVO, HEMIPLEGIC MIGRAINE, CEREBRAL METABOLITES, N-ACETYL ASPARTATE, MUSCLE ENERGY-METABOLISM, NMR-SPECTROSCOPY, PROTON MR SPECTROSCOPY, absolute quantification, migraine without aura, H-1-MRS, phantom replacement technique, MAGNETIC-RESONANCE-SPECTROSCOPY, correction factors
journal title
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Magn. Reson. Mat. Phys. Biol. Med.
volume
23
issue
4
pages
227 - 241
Web of Science type
Article
Web of Science id
000281250700004
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
2.373 (2010)
JCR rank
45/111 (2010)
JCR quartile
2 (2010)
ISSN
0968-5243
DOI
10.1007/s10334-010-0221-z
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1041248
handle
http://hdl.handle.net/1854/LU-1041248
date created
2010-09-13 10:34:21
date last changed
2010-09-13 14:07:05
@article{1041248,
  abstract     = {Several studies have demonstrated differences in migraine patients when performing 1H-MRS; however, no studies have performed H-1-MRS in migraine without aura (MwoA), the most common migraine subtype. The aim of this 1H-MRS study was to elucidate whether any differences could be found between MwoA patients and controls by performing absolute quantification.
1H-MRS was performed in 22 MwoA patients and 25 control subjects. Absolute quantification was based on the phantom replacement technique. Corrections were made for T (1) and T (2) relaxation effects, CSF content, coil loading and temperature. The method was validated by phantom measurements and in vivo measurements in the occipital visual cortex.
After calibration of the quantification procedure and the implementation of the required correction factors, measured absolute concentrations in the visual cortex of MwoA patients showed no significant differences compared to controls, in contrast to relative results obtained in earlier studies.
In this study, we demonstrate the implementation of quantitative in vivo 1H-MRS spectroscopy in migraine patients. Despite rigorous quantification, no spectroscopic abnormalities could be found in patients with migraine without aura.},
  author       = {Reyngoudt, Harmen and De Deene, Yves and Descamps, Benedicte and Paemeleire, Koen and Achten, Eric},
  issn         = {0968-5243},
  journal      = {MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE},
  keyword      = {LOCALIZED PROTON,RELAXATION-TIMES,IN-VIVO,HEMIPLEGIC MIGRAINE,CEREBRAL METABOLITES,N-ACETYL ASPARTATE,MUSCLE ENERGY-METABOLISM,NMR-SPECTROSCOPY,PROTON MR SPECTROSCOPY,absolute quantification,migraine without aura,H-1-MRS,phantom replacement technique,MAGNETIC-RESONANCE-SPECTROSCOPY,correction factors},
  language     = {eng},
  number       = {4},
  pages        = {227--241},
  title        = {1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique},
  url          = {http://dx.doi.org/10.1007/s10334-010-0221-z},
  volume       = {23},
  year         = {2010},
}

Chicago
Reyngoudt, Harmen, Yves De Deene, Benedicte Descamps, Koen Paemeleire, and Eric Achten. 2010. “1H-MRS of Brain Metabolites in Migraine Without Aura: Absolute Quantification Using the Phantom Replacement Technique.” Magnetic Resonance Materials in Physics Biology and Medicine 23 (4): 227–241.
APA
Reyngoudt, H., De Deene, Y., Descamps, B., Paemeleire, K., & Achten, E. (2010). 1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, 23(4), 227–241.
Vancouver
1.
Reyngoudt H, De Deene Y, Descamps B, Paemeleire K, Achten E. 1H-MRS of brain metabolites in migraine without aura: absolute quantification using the phantom replacement technique. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 2010;23(4):227–41.
MLA
Reyngoudt, Harmen, Yves De Deene, Benedicte Descamps, et al. “1H-MRS of Brain Metabolites in Migraine Without Aura: Absolute Quantification Using the Phantom Replacement Technique.” MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE 23.4 (2010): 227–241. Print.