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Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants

Gabriel Krouk, Benoit Lacombe, Agnieszka Bielach UGent, Francine Perrine-Walker, Katerina Malinska, Emmanuelle Mounier, Klara Hoyerova, Pascal Tillard, Sarah Leon, Karin Ljung, et al. (2010) DEVELOPMENTAL CELL. 18(6). p.927-937
abstract
Nitrate is both a nitrogen source for higher plants and a signal molecule regulating their development. In Arabidopsis, the NRT1.1 nitrate transporter is crucial for nitrate signaling governing root growth, and has been proposed to act as a nitrate sensor. However, the sensing mechanism is unknown. Herein we show that NRT1.1 not only transports nitrate but also facilitates uptake of the phytohormone auxin. Moreover, nitrate inhibits NRT1.1-dependent auxin uptake, suggesting that transduction of nitrate signal by NRT1.1 is associated with a modification of auxin transport. Among other effects, auxin stimulates lateral root development. Mutation of NRT1.1 enhances both auxin accumulation in lateral roots and growth of these roots at low, but not high, nitrate concentration. Thus, we propose that NRT1.1 represses lateral root growth at low nitrate availability by promoting basipetal auxin transport out of these roots. This defines a mechanism connecting nutrient and hormone signaling during organ development.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ARABIDOPSIS-THALIANA, ROOT-SYSTEM ARCHITECTURE, GROWTH, FUNCTIONAL-CHARACTERIZATION, CHL1, GENE, PATHWAYS, EFFLUX, SENSOR, SIGNAL
journal title
DEVELOPMENTAL CELL
Dev. Cell
volume
18
issue
6
pages
927 - 937
Web of Science type
Article
Web of Science id
000279366200008
JCR category
DEVELOPMENTAL BIOLOGY
JCR impact factor
13.946 (2010)
JCR rank
2/38 (2010)
JCR quartile
1 (2010)
ISSN
1534-5807
DOI
10.1016/j.devcel.2010.05.008
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1038772
handle
http://hdl.handle.net/1854/LU-1038772
date created
2010-09-08 19:12:00
date last changed
2016-12-19 15:44:32
@article{1038772,
  abstract     = {Nitrate is both a nitrogen source for higher plants and a signal molecule regulating their development. In Arabidopsis, the NRT1.1 nitrate transporter is crucial for nitrate signaling governing root growth, and has been proposed to act as a nitrate sensor. However, the sensing mechanism is unknown. Herein we show that NRT1.1 not only transports nitrate but also facilitates uptake of the phytohormone auxin. Moreover, nitrate inhibits NRT1.1-dependent auxin uptake, suggesting that transduction of nitrate signal by NRT1.1 is associated with a modification of auxin transport. Among other effects, auxin stimulates lateral root development. Mutation of NRT1.1 enhances both auxin accumulation in lateral roots and growth of these roots at low, but not high, nitrate concentration. Thus, we propose that NRT1.1 represses lateral root growth at low nitrate availability by promoting basipetal auxin transport out of these roots. This defines a mechanism connecting nutrient and hormone signaling during organ development.},
  author       = {Krouk, Gabriel and Lacombe, Benoit and Bielach, Agnieszka and Perrine-Walker, Francine and Malinska, Katerina and Mounier, Emmanuelle and Hoyerova, Klara and Tillard, Pascal and Leon, Sarah and Ljung, Karin and Zazimalova, Eva and Benkova, Eva and Nacry, Philippe and Gojon, Alain},
  issn         = {1534-5807},
  journal      = {DEVELOPMENTAL CELL},
  keyword      = {ARABIDOPSIS-THALIANA,ROOT-SYSTEM ARCHITECTURE,GROWTH,FUNCTIONAL-CHARACTERIZATION,CHL1,GENE,PATHWAYS,EFFLUX,SENSOR,SIGNAL},
  language     = {eng},
  number       = {6},
  pages        = {927--937},
  title        = {Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants},
  url          = {http://dx.doi.org/10.1016/j.devcel.2010.05.008},
  volume       = {18},
  year         = {2010},
}

Chicago
Krouk, Gabriel, Benoit Lacombe, Agnieszka Bielach, Francine Perrine-Walker, Katerina Malinska, Emmanuelle Mounier, Klara Hoyerova, et al. 2010. “Nitrate-regulated Auxin Transport by NRT1.1 Defines a Mechanism for Nutrient Sensing in Plants.” Developmental Cell 18 (6): 927–937.
APA
Krouk, G., Lacombe, B., Bielach, A., Perrine-Walker, F., Malinska, K., Mounier, E., Hoyerova, K., et al. (2010). Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants. DEVELOPMENTAL CELL, 18(6), 927–937.
Vancouver
1.
Krouk G, Lacombe B, Bielach A, Perrine-Walker F, Malinska K, Mounier E, et al. Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants. DEVELOPMENTAL CELL. 2010;18(6):927–37.
MLA
Krouk, Gabriel, Benoit Lacombe, Agnieszka Bielach, et al. “Nitrate-regulated Auxin Transport by NRT1.1 Defines a Mechanism for Nutrient Sensing in Plants.” DEVELOPMENTAL CELL 18.6 (2010): 927–937. Print.