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Predictability of cerebral palsy and its characteristics through neonatal cranial ultrasound in a high-risk NICU population

Eveline Himpens, Ann Oostra UGent, Inge Franki, GEORGES VAN MAELE, Piet Vanhaesebrouck and Christine Van den Broeck UGent (2010) EUROPEAN JOURNAL OF PEDIATRICS. 169(10). p.1213-1218
abstract
The aim of the study is to evaluate the predictive value of various types of brain injury detected by ultrasound in the neonatal period for the occurrence of cerebral palsy and its characteristics in a large cohort of high-risk infants. Thousand twenty-one consecutively NICU-admitted high-risk infants were assessed up to the corrected age of at least 2 years. Cerebral palsy (CP) was categorised into spastic or non-spastic, bilateral or unilateral and mild, moderate or severe CP. Different types of brain injury were identified by serial cranial ultrasound (US) during the NICU stay: white matter disease (WMD), haemorrhage, cerebral infarction, deep grey matter and parasagittal cerebral injury. There is a significant overall association between different types of brain injury and gestational age. Only 4% of the children with normal US develop CP. In the presence of any abnormal US image, the likeliness to develop CP is at least seven times higher. Within the group of infants with WMD and haemorrhage, the degree of brain involvement has a clear impact on the occurrence of CP. Concerning the characteristics of CP, deep grey matter lesion predict non-spastic CP versus spastic CP (OR = 31, P < 0.001). Cerebral infarction and haemorrhage grade IV are strong predictors of unilateral spastic CP versus bilateral spastic CP (OR = 49 and 24, respectively, P < 0.001). Deep grey matter lesion is a significant predictor for severe versus mild and moderate CP (OR = 6). In conclusion, neonatal cranial US is a useful tool in predicting CP and its characteristics.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
GESTATIONAL-AGE, MRI, PRETERM INFANTS, BIRTH-WEIGHT INFANTS, Cranial neonatal ultrasound, Brain injury, Cerebral palsy, Gestational age, CHILDREN, BRAIN, ABNORMALITIES, ECHODENSITIES, PREVALENCE, HEMORRHAGE
journal title
EUROPEAN JOURNAL OF PEDIATRICS
Eur. J. Pediatr.
volume
169
issue
10
pages
1213 - 1218
Web of Science type
Article
Web of Science id
000281238700007
JCR category
PEDIATRICS
JCR impact factor
1.644 (2010)
JCR rank
45/105 (2010)
JCR quartile
2 (2010)
ISSN
0340-6199
DOI
10.1007/s00431-010-1207-6
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1038667
handle
http://hdl.handle.net/1854/LU-1038667
date created
2010-09-08 16:08:06
date last changed
2016-12-19 15:46:28
@article{1038667,
  abstract     = {The aim of the study is to evaluate the predictive value of various types of brain injury detected by ultrasound in the neonatal period for the occurrence of cerebral palsy and its characteristics in a large cohort of high-risk infants. Thousand twenty-one consecutively NICU-admitted high-risk infants were assessed up to the corrected age of at least 2 years. Cerebral palsy (CP) was categorised into spastic or non-spastic, bilateral or unilateral and mild, moderate or severe CP. Different types of brain injury were identified by serial cranial ultrasound (US) during the NICU stay: white matter disease (WMD), haemorrhage, cerebral infarction, deep grey matter and parasagittal cerebral injury. There is a significant overall association between different types of brain injury and gestational age. Only 4\% of the children with normal US develop CP. In the presence of any abnormal US image, the likeliness to develop CP is at least seven times higher. Within the group of infants with WMD and haemorrhage, the degree of brain involvement has a clear impact on the occurrence of CP. Concerning the characteristics of CP, deep grey matter lesion predict non-spastic CP versus spastic CP (OR = 31, P {\textlangle} 0.001). Cerebral infarction and haemorrhage grade IV are strong predictors of unilateral spastic CP versus bilateral spastic CP (OR = 49 and 24, respectively, P {\textlangle} 0.001). Deep grey matter lesion is a significant predictor for severe versus mild and moderate CP (OR = 6). In conclusion, neonatal cranial US is a useful tool in predicting CP and its characteristics.},
  author       = {Himpens, Eveline and Oostra, Ann and Franki, Inge and VAN MAELE, GEORGES and Vanhaesebrouck, Piet and Van den Broeck, Christine},
  issn         = {0340-6199},
  journal      = {EUROPEAN JOURNAL OF PEDIATRICS},
  keyword      = {GESTATIONAL-AGE,MRI,PRETERM INFANTS,BIRTH-WEIGHT INFANTS,Cranial neonatal ultrasound,Brain injury,Cerebral palsy,Gestational age,CHILDREN,BRAIN,ABNORMALITIES,ECHODENSITIES,PREVALENCE,HEMORRHAGE},
  language     = {eng},
  number       = {10},
  pages        = {1213--1218},
  title        = {Predictability of cerebral palsy and its characteristics through neonatal cranial ultrasound in a high-risk NICU population},
  url          = {http://dx.doi.org/10.1007/s00431-010-1207-6},
  volume       = {169},
  year         = {2010},
}

Chicago
Himpens, Eveline, Ann Oostra, Inge Franki, GEORGES VAN MAELE, Piet Vanhaesebrouck, and Christine Van den Broeck. 2010. “Predictability of Cerebral Palsy and Its Characteristics Through Neonatal Cranial Ultrasound in a High-risk NICU Population.” European Journal of Pediatrics 169 (10): 1213–1218.
APA
Himpens, E., Oostra, A., Franki, I., VAN MAELE, G., Vanhaesebrouck, P., & Van den Broeck, C. (2010). Predictability of cerebral palsy and its characteristics through neonatal cranial ultrasound in a high-risk NICU population. EUROPEAN JOURNAL OF PEDIATRICS, 169(10), 1213–1218.
Vancouver
1.
Himpens E, Oostra A, Franki I, VAN MAELE G, Vanhaesebrouck P, Van den Broeck C. Predictability of cerebral palsy and its characteristics through neonatal cranial ultrasound in a high-risk NICU population. EUROPEAN JOURNAL OF PEDIATRICS. 2010;169(10):1213–8.
MLA
Himpens, Eveline, Ann Oostra, Inge Franki, et al. “Predictability of Cerebral Palsy and Its Characteristics Through Neonatal Cranial Ultrasound in a High-risk NICU Population.” EUROPEAN JOURNAL OF PEDIATRICS 169.10 (2010): 1213–1218. Print.