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Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery

(2010) CIRCULATION. 122(3). p.273-U107
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Abstract
Background-Control of peripheral resistance arteries by autonomic nerves is essential for the regulation of blood flow. The signals responsible for the maintenance of vascular neuroeffector mechanisms in the adult, however, remain largely unknown. Methods and Results-Here, we report that VEGF(partial derivative/partial derivative) mice with low vascular endothelial growth factor (VEGF) levels suffer defects in the regulation of resistance arteries. These defects are due to dysfunction and structural remodeling of the neuroeffector junction, the equivalent of a synapse between autonomic nerve endings and vascular smooth muscle cells, and to an impaired contractile smooth muscle cell phenotype. Notably, short-term delivery of a VEGF inhibitor to healthy mice also resulted in functional and structural defects of neuroeffector junctions. Conclusions-These findings uncover a novel role for VEGF in the maintenance of arterial neuroeffector function and may help us better understand how VEGF inhibitors cause vascular regulation defects in cancer patients. (Circulation. 2010; 122: 273-281.)
Keywords
arteries, muscle, smooth, nervous system, vascular endothelial growth factor, vasoconstriction, SMOOTH-MUSCLE-CELLS, SYMPATHETIC-NERVOUS-SYSTEM, MESENTERIC-ARTERIES, VEGF, RECEPTOR, EXPRESSION, SURVIVAL, RATS, ERYTHRODYSESTHESIA, DIFFERENTIATION

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Citation

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MLA
Storkebaum, Erik et al. “Impaired Autonomic Regulation of Resistance Arteries in Mice with Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery.” CIRCULATION 122.3 (2010): 273–U107. Print.
APA
Storkebaum, E., de Almodovar, C. R., Meens, M., Zacchigna, S., Mazzone, M., Vanhoutte, G., Vinckier, S., et al. (2010). Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery. CIRCULATION, 122(3), 273–U107.
Chicago author-date
Storkebaum, Erik, Carmen Ruiz de Almodovar, Merlijn Meens, Serena Zacchigna, Massimiliano Mazzone, Greet Vanhoutte, Stefan Vinckier, et al. 2010. “Impaired Autonomic Regulation of Resistance Arteries in Mice with Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery.” Circulation 122 (3): 273–U107.
Chicago author-date (all authors)
Storkebaum, Erik, Carmen Ruiz de Almodovar, Merlijn Meens, Serena Zacchigna, Massimiliano Mazzone, Greet Vanhoutte, Stefan Vinckier, Katarzyna Miskiewicz, Koen Poesen, Diether Lambrechts, Ger MJ Janssen, Gregorio E Fazzi, Patrik Verstreken, Jody Haigh, Paul M Schiffers, Hermann Rohrer, Annemie Van der Linden, Jo GR De Mey, and Peter Carmeliet. 2010. “Impaired Autonomic Regulation of Resistance Arteries in Mice with Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery.” Circulation 122 (3): 273–U107.
Vancouver
1.
Storkebaum E, de Almodovar CR, Meens M, Zacchigna S, Mazzone M, Vanhoutte G, et al. Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery. CIRCULATION. 2010;122(3):273–U107.
IEEE
[1]
E. Storkebaum et al., “Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery,” CIRCULATION, vol. 122, no. 3, pp. 273-U107, 2010.
@article{1035768,
  abstract     = {Background-Control of peripheral resistance arteries by autonomic nerves is essential for the regulation of blood flow. The signals responsible for the maintenance of vascular neuroeffector mechanisms in the adult, however, remain largely unknown.
Methods and Results-Here, we report that VEGF(partial derivative/partial derivative) mice with low vascular endothelial growth factor (VEGF) levels suffer defects in the regulation of resistance arteries. These defects are due to dysfunction and structural remodeling of the neuroeffector junction, the equivalent of a synapse between autonomic nerve endings and vascular smooth muscle cells, and to an impaired contractile smooth muscle cell phenotype. Notably, short-term delivery of a VEGF inhibitor to healthy mice also resulted in functional and structural defects of neuroeffector junctions.
Conclusions-These findings uncover a novel role for VEGF in the maintenance of arterial neuroeffector function and may help us better understand how VEGF inhibitors cause vascular regulation defects in cancer patients. (Circulation. 2010; 122: 273-281.)},
  author       = {Storkebaum, Erik and de Almodovar, Carmen Ruiz and Meens, Merlijn and Zacchigna, Serena and Mazzone, Massimiliano and Vanhoutte, Greet and Vinckier, Stefan and Miskiewicz, Katarzyna and Poesen, Koen and Lambrechts, Diether and Janssen, Ger MJ and Fazzi, Gregorio E and Verstreken, Patrik and Haigh, Jody and Schiffers, Paul M and Rohrer, Hermann and Van der Linden, Annemie and De Mey, Jo GR and Carmeliet, Peter},
  issn         = {0009-7322},
  journal      = {CIRCULATION},
  keywords     = {arteries,muscle,smooth,nervous system,vascular endothelial growth factor,vasoconstriction,SMOOTH-MUSCLE-CELLS,SYMPATHETIC-NERVOUS-SYSTEM,MESENTERIC-ARTERIES,VEGF,RECEPTOR,EXPRESSION,SURVIVAL,RATS,ERYTHRODYSESTHESIA,DIFFERENTIATION},
  language     = {eng},
  number       = {3},
  pages        = {273--U107},
  title        = {Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery},
  url          = {http://dx.doi.org/10.1161/CIRCULATIONAHA.109.929364},
  volume       = {122},
  year         = {2010},
}

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