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Effect of cryogenic treatment on the rheological properties of gelatin hydrogels

Sandra Van Vlierberghe UGent, Peter Dubruel UGent and Etienne Schacht UGent (2010) JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS. 25(5). p.498-512
abstract
Gelatin has the ability to form a gel when cooled below the sol-gel temperature. In this study, the effects of various cryo-parameters, including the number of freeze-thaw cycles, cooling rate, thawing rate, and gelatin concentration, on the material properties were examined. The rheological properties of the cryogels improved with increasing cryo-cycles and decreasing cooling and thawing rates as well as were superior to those of the corresponding hydrogels formed at room temperature. In addition, the critical gelation concentration decreased after repeated cryo-treatments. Methacrylamide-modified gelatin was also treated cryogenically, followed by in situ UV irradiation to enable radical cross-linking. The cross-linking efficiency of specific gelatin concentrations improved with freeze-thawing. Cryogelation can be used to fine-tune the mechanical properties of hydrogels. This is of relevance to tissue engineering where porous gelatin hydrogels are used as biomaterials.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
cryogenic treatment, gelatin, CELL IMMOBILIZATION, SCAFFOLDS, freeze-thaw, rheology, mechanical properties, POLY(VINYL ALCOHOL) CRYOGELS, POLYMER SYSTEMS, COLLAGEN, MICROSTRUCTURE, ARCHITECTURE, CRYOSTRUCTURATION, CHITOSAN, MATRICES
journal title
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
J. Bioact. Compat. Polym.
volume
25
issue
5
pages
498 - 512
Web of Science type
Article
Web of Science id
000281598800005
JCR category
POLYMER SCIENCE
JCR impact factor
2.61 (2010)
JCR rank
14/78 (2010)
JCR quartile
1 (2010)
ISSN
0883-9115
DOI
10.1177/0883911510377254
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1030636
handle
http://hdl.handle.net/1854/LU-1030636
date created
2010-08-31 14:53:51
date last changed
2011-10-01 00:30:56
@article{1030636,
  abstract     = {Gelatin has the ability to form a gel when cooled below the sol-gel temperature. In this study, the effects of various cryo-parameters, including the number of freeze-thaw cycles, cooling rate, thawing rate, and gelatin concentration, on the material properties were examined. The rheological properties of the cryogels improved with increasing cryo-cycles and decreasing cooling and thawing rates as well as were superior to those of the corresponding hydrogels formed at room temperature. In addition, the critical gelation concentration decreased after repeated cryo-treatments. Methacrylamide-modified gelatin was also treated cryogenically, followed by in situ UV irradiation to enable radical cross-linking. The cross-linking efficiency of specific gelatin concentrations improved with freeze-thawing. Cryogelation can be used to fine-tune the mechanical properties of hydrogels. This is of relevance to tissue engineering where porous gelatin hydrogels are used as biomaterials.},
  author       = {Van Vlierberghe, Sandra and Dubruel, Peter and Schacht, Etienne},
  issn         = {0883-9115},
  journal      = {JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS},
  keyword      = {cryogenic treatment,gelatin,CELL IMMOBILIZATION,SCAFFOLDS,freeze-thaw,rheology,mechanical properties,POLY(VINYL ALCOHOL) CRYOGELS,POLYMER SYSTEMS,COLLAGEN,MICROSTRUCTURE,ARCHITECTURE,CRYOSTRUCTURATION,CHITOSAN,MATRICES},
  language     = {eng},
  number       = {5},
  pages        = {498--512},
  title        = {Effect of cryogenic treatment on the rheological properties of gelatin hydrogels},
  url          = {http://dx.doi.org/10.1177/0883911510377254},
  volume       = {25},
  year         = {2010},
}

Chicago
Van Vlierberghe, Sandra, Peter Dubruel, and Etienne Schacht. 2010. “Effect of Cryogenic Treatment on the Rheological Properties of Gelatin Hydrogels.” Journal of Bioactive and Compatible Polymers 25 (5): 498–512.
APA
Van Vlierberghe, S., Dubruel, P., & Schacht, E. (2010). Effect of cryogenic treatment on the rheological properties of gelatin hydrogels. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 25(5), 498–512.
Vancouver
1.
Van Vlierberghe S, Dubruel P, Schacht E. Effect of cryogenic treatment on the rheological properties of gelatin hydrogels. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS. 2010;25(5):498–512.
MLA
Van Vlierberghe, Sandra, Peter Dubruel, and Etienne Schacht. “Effect of Cryogenic Treatment on the Rheological Properties of Gelatin Hydrogels.” JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 25.5 (2010): 498–512. Print.