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Development of a new inactivated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine

Iris Delrue UGent (2010)
abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is responsible for reproduction disorders in sows, which leads to tremendous economic losses in the pig industry worldwide. It is also associated with porcine respiratory disease complex (PRDC), which supports massive use of antibiotics. Although several modified live virus (MLV) and killed virus (KV) vaccines are on the market, PRRSV remains difficult to control in the field. The major aim of this thesis was to develop a new experimental inactivated PRRSV vaccine. The different processes to develop a vaccine are virus production, virus inactivation or attenuation and vaccine formulation. In this thesis, the virus production and the virus inactivation of PRRSV were optimized to develop an efficient KV vaccine. The first section of chapter 1 gives an introduction on PRRSV, more particular its history, classification, virus structure, genomic organization, viral proteins, replication cycle, clinical signs, pathogenesis, innate and adaptive immune response to PRRSV and the available vaccines. A second section of chapter 1 gives an overview of different viral inactivation procedures, such as cross-linkers (formaldehyde, glutaraldehyde and AT-2), denaturing agents (pH and temperature), irradiation (ultraviolet (UV) and gamma irradiation) and alkylating agents (binary ethyleneimine (BEI)), and their effect on viruses.
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
keyword
CD163, sialoadhesin, vaccine, PRRSV, inactivation
pages
180 pages
publisher
Ghent University. Faculty of Veterinary Medicine
place of publication
Merelbeke, Belgium
defense location
Merelbeke : Faculteit Diergeneeskunde (auditorium Hoogbouw)
defense date
2010-07-08 16:00
ISBN
9789058 642257
language
English
UGent publication?
yes
classification
D1
additional info
dissertation in part contains copyrighted material
copyright statement
I have transferred the copyright for this publication to the publisher
id
1026196
handle
http://hdl.handle.net/1854/LU-1026196
date created
2010-08-19 15:51:45
date last changed
2010-08-23 11:33:41
@phdthesis{1026196,
  abstract     = {Porcine reproductive and respiratory syndrome virus (PRRSV) is responsible for reproduction disorders in sows, which leads to tremendous economic losses in the pig industry worldwide. It is also associated with porcine respiratory disease complex (PRDC), which supports massive use of antibiotics. Although several modified live virus (MLV) and killed virus (KV) vaccines are on the market, PRRSV remains difficult to control in the field. The major aim of this thesis was to develop a new experimental inactivated PRRSV vaccine. The different processes to develop a vaccine are virus production, virus inactivation or attenuation and vaccine formulation. In this thesis, the virus production and the virus inactivation of PRRSV were optimized to develop an efficient KV vaccine.
The first section of chapter 1 gives an introduction on PRRSV, more particular its history, classification, virus structure, genomic organization, viral proteins, replication cycle, clinical signs, pathogenesis, innate and adaptive immune response to PRRSV and the available vaccines. A second section of chapter 1 gives an overview of different viral inactivation procedures, such as cross-linkers (formaldehyde, glutaraldehyde and AT-2), denaturing agents (pH and temperature), irradiation (ultraviolet (UV) and gamma irradiation) and alkylating agents (binary ethyleneimine (BEI)), and their effect on viruses.},
  author       = {Delrue, Iris},
  isbn         = {9789058 642257},
  keyword      = {CD163,sialoadhesin,vaccine,PRRSV,inactivation},
  language     = {eng},
  pages        = {180},
  publisher    = {Ghent University. Faculty of Veterinary Medicine},
  school       = {Ghent University},
  title        = {Development of a new inactivated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine},
  year         = {2010},
}

Chicago
Delrue, Iris. 2010. “Development of a New Inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Vaccine”. Merelbeke, Belgium: Ghent University. Faculty of Veterinary Medicine.
APA
Delrue, I. (2010). Development of a new inactivated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine. Ghent University. Faculty of Veterinary Medicine, Merelbeke, Belgium.
Vancouver
1.
Delrue I. Development of a new inactivated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine. [Merelbeke, Belgium]: Ghent University. Faculty of Veterinary Medicine; 2010.
MLA
Delrue, Iris. “Development of a New Inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Vaccine.” 2010 : n. pag. Print.