Ghent University Academic Bibliography

Advanced

Comparison of yttrium-90 SPECT and PET images

Erwann Rault UGent, Enrico Clementel UGent, Stefaan Vandenberghe UGent, Yves D'Asseler, Roel Van Holen UGent, Jan De Beenhouwer UGent and Steven Staelens UGent (2010) JOURNAL OF NUCLEAR MEDICINE. 51(suppl. 2). p.35-35
abstract
Objectives: Yttrium-90 (90Y) beta minus emission allows a high and well located dose delivery in the treatment of unresectable hepatocellular carcinomas, but the absence of low energy gamma emission limits accurate dosimetry with SPECT. Most investigators use bremsstrahlung photons to generate SPECT images of 90Y biodistribution. As an alternative, the use of PET has recently been proposed, detecting the annihilation photons generated after internal pair production in 32 out of 10 millions decays. The aim of this study is to compare the effectiveness of PET and SPECT for the dosimetry of 90Y microspheres therapies. Methods: A Philips Gemini scanner, energy window 410-660 keV, was used for PET. A Prism 3000XP scanner with MEGP collimators, 50-150 keV window, was used for SPECT. Quantitative accuracy was compared with an anthropomorphic torso phantom. A liver:lung ratio of 5.25:1 was chosen to represent an average patient. Total activity was 370 MBq. Scan times were prolonged to match the timexactivity product of a clinical scan (4 million MBqxs). Spatial resolution was measured on a line source centered on a cylindrical water filled-phantom (18 cm diameter). Count rates of both modalities were compared acquiring a small spherical source at the center of the FOV, in identical time/activity conditions. PET images were generated using the scanner's RAMLA reconstruction, including scatter and attenuation correction; 3 iterations and 8 subsets were used. SPECT images were generated using a custom MLEM and bremsstrahlung-optimized scatter and attenuation correction. 24 iterations were used. Results: Quantitation of the total liver activity shows a 7% error in PET vs a 16% in SPECT. PET spatial resolution is 6.4 vs 15.3 mm for SPECT. The count rate obtained for the spherical source in identical acquisition condition is 6.25 times higher for SPECT than for PET resulting in less noisy images. Conclusions: Both techniques seem to deliver reasonable accuracy. 90Y PET achieves good quantitation results without any bremsstralhung specific correction
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
SPECT, Yttrium-90, PET images
in
JOURNAL OF NUCLEAR MEDICINE
J. Nucl. Med.
volume
51
issue
suppl. 2
pages
35 - 35
conference name
57th Annual meeting of the Society of Nucelar Medicine (SNM 2010)
conference location
Salt Lake City, UT, USA
conference start
2010-06-05
conference end
2010-06-09
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
7.022 (2010)
JCR rank
1/111 (2010)
JCR quartile
4 (2010)
ISSN
0161-5505
language
English
UGent publication?
yes
classification
C3
id
1024585
handle
http://hdl.handle.net/1854/LU-1024585
alternative location
C:\Users\gmdvolde\AppData\Local\Temp\Comparison_of_yttrium-90_SPECT_and_PET_images_--_Rault_et_al__51__1002__125_--_Society_of_Nuclear_Medicine_Annual_Meeting_Abstracts.mht
date created
2010-08-17 11:20:23
date last changed
2016-12-19 15:35:34
@inproceedings{1024585,
  abstract     = {Objectives: Yttrium-90 (90Y) beta minus emission allows a high and well located dose delivery in the treatment of unresectable hepatocellular carcinomas, but the absence of low energy gamma emission limits accurate dosimetry with SPECT. Most investigators use bremsstrahlung photons to generate SPECT images of 90Y biodistribution. As an alternative, the use of PET has recently been proposed, detecting the annihilation photons generated after internal pair production in 32 out of 10 millions decays. The aim of this study is to compare the effectiveness of PET and SPECT for the dosimetry of 90Y microspheres therapies. 
Methods: A Philips Gemini scanner, energy window 410-660 keV, was used for PET. A Prism 3000XP scanner with MEGP collimators, 50-150 keV window, was used for SPECT. Quantitative accuracy was compared with an anthropomorphic torso phantom. A liver:lung ratio of 5.25:1 was chosen to represent an average patient. Total activity was 370 MBq. Scan times were prolonged to match the timexactivity product of a clinical scan (4 million MBqxs). Spatial resolution was measured on a line source centered on a cylindrical water filled-phantom (18 cm diameter). Count rates of both modalities were compared acquiring a small spherical source at the center of the FOV, in identical time/activity conditions. PET images were generated using the scanner's RAMLA reconstruction, including scatter and attenuation correction; 3 iterations and 8 subsets were used. SPECT images were generated using a custom MLEM and bremsstrahlung-optimized scatter and attenuation correction. 24 iterations were used. 
Results: Quantitation of the total liver activity shows a 7\% error in PET vs a 16\% in SPECT. PET spatial resolution is 6.4 vs 15.3 mm for SPECT. The count rate obtained for the spherical source in identical acquisition condition is 6.25 times higher for SPECT than for PET resulting in less noisy images. 
Conclusions: Both techniques seem to deliver reasonable accuracy. 90Y PET achieves good quantitation results without any bremsstralhung specific correction},
  author       = {Rault, Erwann and Clementel, Enrico and Vandenberghe, Stefaan and D'Asseler, Yves and Van Holen, Roel and De Beenhouwer, Jan and Staelens, Steven},
  booktitle    = {JOURNAL OF NUCLEAR MEDICINE},
  issn         = {0161-5505},
  keyword      = {SPECT,Yttrium-90,PET images},
  language     = {eng},
  location     = {Salt Lake City, UT, USA},
  number       = {suppl. 2},
  pages        = {35--35},
  title        = {Comparison of yttrium-90 SPECT and PET images},
  url          = {C:{\textbackslash}Users{\textbackslash}gmdvolde{\textbackslash}AppData{\textbackslash}Local{\textbackslash}Temp{\textbackslash}Comparison\_of\_yttrium-90\_SPECT\_and\_PET\_images\_--\_Rault\_et\_al\_\_51\_\_1002\_\_125\_--\_Society\_of\_Nuclear\_Medicine\_Annual\_Meeting\_Abstracts.mht},
  volume       = {51},
  year         = {2010},
}

Chicago
Rault, Erwann, Enrico Clementel, Stefaan Vandenberghe, YVES D’ASSELER, Roel Van Holen, Jan De Beenhouwer, and Steven Staelens. 2010. “Comparison of Yttrium-90 SPECT and PET Images.” In Journal of Nuclear Medicine, 51:35–35.
APA
Rault, E., Clementel, E., Vandenberghe, S., D’ASSELER, Y., Van Holen, R., De Beenhouwer, J., & Staelens, S. (2010). Comparison of yttrium-90 SPECT and PET images. JOURNAL OF NUCLEAR MEDICINE (Vol. 51, pp. 35–35). Presented at the 57th Annual meeting of the Society of Nucelar Medicine (SNM 2010).
Vancouver
1.
Rault E, Clementel E, Vandenberghe S, D’ASSELER Y, Van Holen R, De Beenhouwer J, et al. Comparison of yttrium-90 SPECT and PET images. JOURNAL OF NUCLEAR MEDICINE. 2010. p. 35–35.
MLA
Rault, Erwann, Enrico Clementel, Stefaan Vandenberghe, et al. “Comparison of Yttrium-90 SPECT and PET Images.” Journal of Nuclear Medicine. Vol. 51. 2010. 35–35. Print.